{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T23:40:05Z","timestamp":1755819605790,"version":"3.44.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renal artery involvement (RAI) can cause renovascular hypertension and\/or\n                        organ dysfunction in Takayasu arteritis (TA). The literature includes few\n                        data regarding renal involvement in pediatric-onset TA patients. We aimed to\n                        describe the renal characteristics, management, and outcomes in TA patients\n                        with RAI.<\/jats:p><jats:p>We retrospectively reviewed the clinical, laboratory, and radiological\n                        findings, treatments, and outcomes in TA patients with RAI, diagnosed\n                        between 2008 and 2022.<\/jats:p><jats:p>Nine of 20 pediatric-onset TA patients had RAI; their median age was 14.7\n                        (13.1\u201315.5) years. Five patients had bilateral RAI. Six patients presented\n                        with hypertension, 2 of which as hypertensive emergency. Five patients had\n                        proteinuria (median urine protein\/ creatinine ratio: 1.75\u2009mg\/mg), one\n                        patient had microscopic hematuria. Kidney size asymmetry was detected in 5\n                        patients. The median duration of follow-up was 35 months (22\u201345). All\n                        patients received steroids, and TNF-\u03b1 and\/or IL-6 inhibitors. One patient\n                        underwent percutaneous transluminal angioplasty (PTA), 2 patients underwent\n                        thoraco-abdominal aortic and aortorenal bypass. At last visit there was no\n                        progression in renovascular findings in 75% of the patients, and all\n                        patients had an eGFR&gt;60\u2009ml\/min\/1.73m2.<\/jats:p><jats:p>Hypertension, proteinuria, and kidney size asymmetry can accompany a\n                        substantial number of pediatric-onset TA patients with RAI. Prompt\n                        initiation of treatment, including PTA or surgery, result in good mid-term\n                        renal outcomes.<\/jats:p>","DOI":"10.1055\/a-2568-6472","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T22:59:28Z","timestamp":1755817168000},"source":"Crossref","is-referenced-by-count":0,"title":["Renal Artery Involvement in Pediatric-Onset Takayasu Arteritis: Renal\n                    Characteristics and Mid-Term Follow-up Outcomes"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3419-1661","authenticated-orcid":false,"given":"Tugba","family":"Tastemel Ozturk","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Hacettepe University Faculty of\n                    Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2681-4905","authenticated-orcid":false,"given":"Demet","family":"Baltu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Hacettepe University Faculty of\n                    Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eda Didem","family":"Kurt-Sukur","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Hacettepe University Faculty of\n                    Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bora","family":"Gulhan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Hacettepe University Faculty of\n                    Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yelda","family":"Bilginer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Hacettepe University Faculty of\n                    Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seza","family":"Ozen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Hacettepe University Faculty of\n                    Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berna","family":"Oguz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Radiology, Hacettepe University Faculty of\n                    Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilge","family":"Volkan Salanci","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Hacettepe University Faculty of\n                    Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Duzova","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Hacettepe University Faculty of\n                    Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Ozaltin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Hacettepe University Faculty of\n                    Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rezan","family":"Topaloglu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Hacettepe University Faculty of\n                    Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1136\/ard.2005.046300","article-title":"EULAR\/PReS endorsed consensus criteria for the classification of childhood\n                    vasculitides","volume":"65","author":"S Ozen","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"872313","DOI":"10.3389\/fped.2022.872313","article-title":"An Update on Childhood-Onset Takayasu Arteritis","volume":"10","author":"F A Aeschlimann","year":"2022","journal-title":"Front Pediatr"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1093\/rheumatology\/keq167","article-title":"Takayasu arteritis in children and adolescents","volume":"49","author":"J Brunner","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1007\/s10067-022-06318-5","article-title":"Presentation and clinical course of pediatric-onset versus adult-onset Takayasu\n                    arteritis-a systematic review and meta-analysis","volume":"41","author":"D P Misra","year":"2022","journal-title":"Clin 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Rheumatol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.rbre.2016.01.004","article-title":"Brazilian multicenter study of 71 patients with juvenile-onset Takayasu's\n                    arteritis: clinical and angiographic features","volume":"56","author":"G Clemente","year":"2016","journal-title":"Rev Bras Reumatol Engl Ed"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13075-018-1790-x","article-title":"Clinical course and prognostic factors of childhood Takayasu's arteritis:\n                    over 15-year comprehensive analysis of 101 patients","volume":"21","author":"L Fan","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1093\/icvts\/ivz157","article-title":"Surgical management of renovascular hypertension in children and young adults: a\n                    13-year experience","volume":"29","author":"O Peker","year":"2019","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"813","DOI":"10.7196\/SAMJ.2016.v106i8.10490","article-title":"Salvageability of renal function following renal revascularisation in children\n                    with Takayasu's arteritis-induced renal artery stenosis","volume":"106","author":"P N Obiagwu","year":"2016","journal-title":"S Afr Med J"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1007\/s00467-015-3049-y","article-title":"Impact of revascularization on hypertension in children with Takayasu's\n                    arteritis-induced renal artery stenosis: a 21-year review","volume":"30","author":"T A Ladapo","year":"2015","journal-title":"Pediatr Nephrol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/s13075-017-1452-4","article-title":"Childhood Takayasu arteritis: disease course and response to therapy","volume":"19","author":"F A Aeschlimann","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"466","DOI":"10.3899\/jrheum.160974","article-title":"Longterm Outcomes of Renal Artery Involvement in Takayasu Arteritis","volume":"44","author":"S Hong","year":"2017","journal-title":"J Rheumatol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1136\/ard.2009.116657","article-title":"Paediatric Rheumatology International Trials Organisation (PRINTO).\n                    EULAR\/PRINTO\/PRES criteria for Henoch-Sch\u00f6nlein purpura, childhood polyarteritis\n                    nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis:\n                    Ankara 2008. 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