{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:11:50Z","timestamp":1768338710853,"version":"3.49.0"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"08","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                  Background\u2002Lumen-apposing metal stents (LAMS) are widely used to drain walled-off necrosis (WON). LAMS occlusion is a significant clinical problem and identification of risk factors for LAMS occlusion could contribute to novel preventive strategies. A previous study suggested contradictory effects of proton pump inhibitors (PPIs) on occlusion and necrosectomy rates.<\/jats:p><jats:p>\n                  Methods\u2002We conducted a Europe-wide multicenter retrospective cohort study assessing WONs drained by LAMS. The primary aims were to assess the strength of association between PPI intake and LAMS occlusion and necrosectomy rates, respectively. The secondary aim was to assess the strength of association between PPI intake and other LAMS-associated complications. Multiple mixed-effects models were used to control for possible confounding covariates.<\/jats:p><jats:p>\n                  Results\u2002893 patients with 967 LAMS from 17 centers were included. After excluding incomplete datasets and patients who took PPIs intermittently, 768 LAMS remained. The overall occlusion rate was 28.0\u200a%. Most occlusions occurred within 10 days. Most patients received PPIs continuously (n\u200a=\u200a577 vs. no intake n\u200a=\u200a191). In patients who did not use PPIs continuously, lower rates of LAMS occlusion (odds ratio [OR] 0.61, P\u200a=\u200a0.04) and necrosectomies (incidence rate ratio 0.8, P\u200a=\u200a0.006) were observed. A post hoc analysis exhibited a dose- and compound-dependent effect of PPI intake on necrosectomy rate. No increase in other complications in the non-PPI group, such as bleeding events (OR 1.14) were observed. <\/jats:p><jats:p>\n                  Conclusion\u2002PPI intake was associated with higher rates of LAMS occlusion and necrosectomy.<\/jats:p>","DOI":"10.1055\/a-2569-7056","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T19:41:14Z","timestamp":1743450074000},"page":"829-838","source":"Crossref","is-referenced-by-count":2,"title":["Effect of proton pump inhibitors on occlusion of lumen-apposing metal stents and rate of endoscopic necrosectomies: a Europe-wide multicenter cohort study"],"prefix":"10.1055","volume":"57","clinical-trial-number":[{"clinical-trial-number":"nct05817721","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Jacob","family":"Hamm","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alzbeta","family":"Busana","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Amanzada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Arlt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital Oldenburg, Oldenburg, Germany"},{"name":"Department of Gastroenterology, Israelitisches Krankenhaus, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Asendorf","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, University Medical Center Goettingen, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Carswell","sequence":"additional","affiliation":[{"name":"HPB and Transplant Unit, Freeman Hospital, Newcastle Upon Tyne, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Denzer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Elsing","sequence":"additional","affiliation":[{"name":"Department of Oncology, Gastroenterology, Hepatology and Pneumology, University Hospital Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Frost","sequence":"additional","affiliation":[{"name":"Department of Medicine A, University Medicine Greifswald, Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9597-6377","authenticated-orcid":false,"given":"Lucia","family":"Guilabert","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital General Universitario Dr. Balmis, ISABIAL (Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante), Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-2746","authenticated-orcid":false,"given":"Karim","family":"Hamesch","sequence":"additional","affiliation":[{"name":"Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Hollenbach","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital Marburg, Marburg, Germany"},{"name":"Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Hegyi","sequence":"additional","affiliation":[{"name":"Translational Pancreatology Research Group, Interdisciplinary Center of Excellence for Research Development and Innovation, University of Szeged, Szeged, Hungary"},{"name":"Institute for Translational Medicine, Medical School, University of P\u00e9cs, P\u00e9cs, Hungary"},{"name":"Institute of Pancreatic Diseases and Centre for Translational Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kleger","sequence":"additional","affiliation":[{"name":"Institute of Molecular Oncology and Stem Cell Biology, University Hospital Ulm, Ulm, Germany"},{"name":"Division of Interdisciplinary Pancreatology, Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Krivinka","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine \u2013 Gastroenterology and Geriatrics, University Hospital Olomouc, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2985-8759","authenticated-orcid":false,"given":"Lumir","family":"Kunovsky","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine \u2013 Gastroenterology and Geriatrics, University Hospital Olomouc, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic"},{"name":"Department of Surgery, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic"},{"name":"Department of Gastroenterology and Digestive Endoscopy, Masaryk Memorial Cancer Institute, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Meinhardt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital Oldenburg, Oldenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veit","family":"Phillip","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine II, Technical University of Munich, TUM School of Medicine and Health, TUM University Hospital, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Schlosser-Hupf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology and Infectious diseases, University Hospital Regensburg, Regensburg, Bavaria, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6047-334X","authenticated-orcid":false,"given":"Simon","family":"Sirtl","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University Hospital LMU Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Welsch","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Diabetology and Infectiology, Klinikum Hanau, Hanau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Cardinal von Widdern","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Martin Luther University Halle-Wittenberg, Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albrecht","family":"Neesse","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2465-8927","authenticated-orcid":false,"given":"Christoph","family":"Ammer-Herrmenau","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"PROTOCOL working 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Eur J Clin Pharmacol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1136\/gutjnl-2021-325812","article-title":"Lumen-apposing metal stents for drainage of pancreatic fluid collections: does timing of removal matter?","volume":"71","author":"M Nayar","year":"2022","journal-title":"Gut"},{"key":"ref19","first-page":"CD005415","article-title":"Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding","volume":"1","author":"T Kanno","year":"2022","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2569-7056.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T22:30:49Z","timestamp":1753828249000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2569-7056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,31]]},"references-count":19,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2025,7,29]]},"published-print":{"date-parts":[[2025,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2569-7056","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,3,31]]},"published":{"date-parts":[[2025,3,31]]}}}