{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T04:23:42Z","timestamp":1745987022803,"version":"3.40.4"},"reference-count":69,"publisher":"Georg Thieme Verlag KG","funder":[{"name":"Ministry of Health, Labor and Welfare of Japan","award":["21FC1008"],"award-info":[{"award-number":["21FC1008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coronavirus disease 2019 (COVID-19) is often associated with thrombosis. Elevated levels of soluble C-type lectin-like receptor 2 (sCLEC-2), a biomarker for platelet activation, have been reported in COVID-19. Therefore, we examined the behavior of sCLEC-2 levels and their relationship with thrombosis.<\/jats:p><jats:p>The clinical course of inflammatory and thrombotic biomarkers was assessed in 271 patients with COVID-19.<\/jats:p><jats:p>Inflammatory biomarkers such as C-reactive protein, procalcitonin, and presepsin levels were significantly increased in patients with COVID-19, and these behaviors differed among the clinical course or stages. The plasma D-dimer levels increased slightly and gradually. Platelet counts were within the normal range, and plasma sCLEC-2 levels were markedly increased in most patients with COVID-19. There were 17 patients with thrombosis in this study. Although there was no significant difference in various biomarkers between COVID-19 patients with and without thrombosis, the super formula of sCLEC-2xD-dimer\/platelet count in patients with thrombosis was significantly higher than in those without thrombosis. Furthermore, this super formula was significantly higher in COVID-19 patients with severe or critical illness than in those with mild or moderate illness.<\/jats:p><jats:p>Elevation of the super formula of sCLEC-2xD-dimer\/platelet count was associated with the thrombosis in patients with COVID-19 suggesting the thrombosis in COVID-19 may be caused by the development of microthrombosis.<\/jats:p>","DOI":"10.1055\/a-2572-1170","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T23:21:26Z","timestamp":1743636086000},"source":"Crossref","is-referenced-by-count":0,"title":["Implications of Soluble C-type Lectin-Like Receptor 2 Levels in Patients with Coronavirus Disease 2019-Associated with Thrombosis"],"prefix":"10.1055","author":[{"given":"Hideo","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Mie Prefectural General Medical Center, Yokkaichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Shiraki","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Mie Prefectural General Medical Center, Yokkaichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhuko","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mie Prefectural General Medical Center, Yokkaichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Moritani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Mie Prefectural General Medical Center, Yokkaichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mie Prefectural General Medical Center, Yokkaichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akitaka","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Center, Mie Prefectural General Medical Center, Yokkaichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Tomida","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Center, Mie Prefectural General Medical Center, Yokkaichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Mie Prefectural General Medical Center, Yokkaichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Kawamura","sequence":"additional","affiliation":[{"name":"IVD Division, PHC Corporation, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motomu","family":"Shimaoka","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Iba","sequence":"additional","affiliation":[{"name":"Department of Emergency and Disaster Medicine, Juntendo University, Graduate School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideto","family":"Shimpo","sequence":"additional","affiliation":[{"name":"Mie Prefectural General Medical Center, Yokkaichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"F Zhou","year":"2020","journal-title":"Lancet"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1007\/s11606-020-05762-w","article-title":"Review of the clinical characteristics of coronavirus disease 2019 (COVID-19)","volume":"35","author":"F Jiang","year":"2020","journal-title":"J Gen Intern 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