{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T08:35:56Z","timestamp":1764318956608,"version":"3.46.0"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zentralbl Chir"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Das Pleuramesotheliom (PM) ist ein hochaggressiver Tumor, der in engem Zusammenhang mit einer fr\u00fcheren Asbestexposition steht. Symptome treten i.\u00a0d.\u00a0R. erst 20\u201350 Jahre nach Exposition auf. Je nach histologischem Subtyp des PM variiert die Prognose, die mediane \u00dcberlebenszeit liegt jedoch bei nur 12\u201318 Monaten. Die Bildgebung spielt eine zentrale Rolle im Management von PM-Patienten, insbesondere bei der Beurteilung der Operabilit\u00e4t und des Therapieansprechens. Jedoch stellt das PM eine besondere Herausforderung f\u00fcr die Radiologie dar, da es selten ist, eine komplexe Morphologie aufweist und zu einer gleichzeitigen Invasion mehrerer Gewebsschichten neigt. Die kontrastmittelgest\u00fctzte Computertomografie (CT) stellt die zentrale bildgebende Methode in der Diagnose, pr\u00e4operativen Planung und Therapie\u00fcberwachung des PM dar. Idealerweise wird eine CT sowohl des Thorax als auch des Abdomens durchgef\u00fchrt, um den gesamten pleuralen Raum abzubilden. Tumordicke und -volumen, die mittels\n      CT bestimmt werden, sind wichtige prognostische Faktoren f\u00fcr das \u00dcberleben von PM-Patienten. Zus\u00e4tzlich bietet die PET\/CT, die radioaktiv markierte Fluordesoxyglukose (18F-FDG) verwendet, wertvolle Einblicke in den Tumorstoffwechsel. Da das PM typischerweise metabolisch aktiv ist, eignet sich die PET\/CT besonders gut zur Detektion kleinerer L\u00e4sionen, okkulter Metastasen und zur Beurteilung morphologisch unklarer L\u00e4sionen. Die Magnetresonanztomografie (MRT) bietet hingegen deutliche Vorteile gegen\u00fcber der CT aufgrund ihres \u00fcberlegenen Weichteilkontrasts, insbesondere bei der Darstellung des Tumorausma\u00dfes und der Infiltration benachbarter Strukturen. Dynamische Kontrastmitteluntersuchungen, Diffusionsbildgebung und 4D-Sequenzen liefern weitere wertvolle Zusatzinformationen. Orientierend an den \u201eBest Practices\u201c des Experten-Panels \u201eInternational Mesothelioma Interest Group\u201c (iMig), geben wir einen \u00dcberblick \u00fcber die g\u00e4ngigen bildgebenden Verfahren, darunter das\n      konventionelle R\u00f6ntgen, die CT, MRT und PET\/CT. Au\u00dferdem gehen wir auf das Staging anhand der TNM-Klassifikation (Tumor, Nodus, Metastasen) ein, was die lokale Invasion des Tumors (T), die Lymphknotenbeteiligung (N) und das Vorliegen von Metastasen (M) bewertet. Au\u00dferdem zeigen wir Beispiele f\u00fcr die Beurteilung des Therapieansprechens und erl\u00e4utern neuere Entwicklungen in der bildgebenden Diagnostik.<\/jats:p>","DOI":"10.1055\/a-2576-6585","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T19:49:18Z","timestamp":1747684158000},"page":"S39-S49","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Moderne radiologische Ans\u00e4tze zu Diagnostik und Staging des pleuralen Mesothelioms"],"prefix":"10.1055","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8326-0777","authenticated-orcid":false,"given":"Sabine","family":"Franckenberg","sequence":"additional","affiliation":[{"name":"Diagnostische und Interventionelle Radiologie, Universit\u00e4tsSpital Z\u00fcrich, Z\u00fcrich, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Theissen-Lauk","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Thoraxchirurgie, Universit\u00e4tsSpital Z\u00fcrich, Z\u00fcrich, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Frauenfelder","sequence":"additional","affiliation":[{"name":"Diagnostische und Interventionelle Radiologie, Universit\u00e4tsSpital Z\u00fcrich, Z\u00fcrich, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1148\/radiographics.12.6.1439021","article-title":"Imaging manifestations of pleural tumors","volume":"12","author":"MC Dynes","year":"1992","journal-title":"Radiographics"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1055\/s-0041-1728714","article-title":"Old Borders and New Horizons in Multimodality Imaging of Malignant Pleural Mesothelioma","volume":"70","author":"K Martini","year":"2022","journal-title":"Thorac Cardiovasc Surg"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ejcts\/ezaa158","article-title":"ERS\/ESTS\/EACTS\/ESTRO guidelines for the management of malignant pleural mesothelioma","volume":"58","author":"I Opitz","year":"2020","journal-title":"Eur J Cardiothorac Surg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"750","DOI":"10.3390\/diagnostics12030750","article-title":"The Use of Chest Magnetic Resonance Imaging in Malignant Pleural Mesothelioma Diagnosis","volume":"12","author":"F Volpi","year":"2022","journal-title":"Diagnostics"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/s0720-048x(00)00168-6","article-title":"Malignant pleural disease","volume":"34","author":"L Bonomo","year":"2000","journal-title":"Eur J Radiol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.0175-2023","article-title":"Contemporary management of mesothelioma","volume":"20","author":"MDJ Neilly","year":"2024","journal-title":"Breathe (Sheff)"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"107832","DOI":"10.1016\/j.lungcan.2024.107832","article-title":"Imaging in pleural Mesothelioma: A review of the 16th International Conference of the International Mesothelioma Interest Group","volume":"193","author":"SG Armato","year":"2024","journal-title":"Lung Cancer"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.ctrv.2007.07.012","article-title":"Assessment of tumor response in malignant pleural mesothelioma","volume":"33","author":"GL Ceresoli","year":"2007","journal-title":"Cancer Treat Rev"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41379-021-00895-7","article-title":"Pleural mesothelioma classification-update and challenges","volume":"35","author":"S Dacic","year":"2022","journal-title":"Mod Pathol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1097\/jto.0000000000000663","article-title":"Introduction to The 2015 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart","volume":"10","author":"WD Travis","year":"2015","journal-title":"J Thorac Oncol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/s0140-6736(20)32714-8","article-title":"First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial","volume":"397","author":"P Baas","year":"2021","journal-title":"Lancet"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1055\/a-2202-5445","article-title":"[Interdisciplinary diagnostics and therapy of malignant mesothelioma]","volume":"78","author":"LIS van der Linde","year":"2024","journal-title":"Pneumologie"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2024.104481","article-title":"Unleashing precision: A review of targeted approaches in pleural mesothelioma","volume":"203","author":"M Occhipinti","year":"2024","journal-title":"Crit Rev Oncol Hematol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1016\/j.jtho.2019.08.012","article-title":"Radiologic Considerations and Standardization of Malignant Pleural Mesothelioma Imaging Within Clinical Trials: Consensus Statement from the NCI Thoracic Malignancy Steering Committee \u2013 International Association for the Study of Lung Cancer \u2013 Mesothelioma Applied Research Foundation Clinical Trials Planning Meeting","volume":"14","author":"RR Gill","year":"2019","journal-title":"J Thorac Oncol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.jtho.2022.11.018","article-title":"Considerations for Imaging of Malignant Pleural Mesothelioma: A Consensus Statement from the International Mesothelioma Interest Group","volume":"18","author":"SI Katz","year":"2023","journal-title":"J Thorac Oncol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1200\/JCO.2017.76.6394","article-title":"Treatment of Malignant Pleural Mesothelioma: American Society of Clinical Oncology Clinical Practice Guideline","volume":"36","author":"HL Kindler","year":"2018","journal-title":"J Clin Oncol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s00508-016-1080-z","article-title":"Management of malignant pleural mesothelioma \u2013 part\u00a01: epidemiology, diagnosis, and staging: Consensus of the Austrian Mesothelioma Interest Group (AMIG)","volume":"128","author":"C Geltner","year":"2016","journal-title":"Wien Klin Wochenschr"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.crad.2019.12.001","article-title":"The role of imaging in malignant pleural mesothelioma: an update after the 2018 BTS guidelines","volume":"75","author":"S Sinha","year":"2020","journal-title":"Clin Radiol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"58","DOI":"10.21037\/shc.2018.07.01","article-title":"Advances in mesothelioma imaging and implications for surgical management","volume":"2","author":"KG Blyth","year":"2018","journal-title":"Shanghai Chest"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s40644-021-00415-5","article-title":"Implementing CT tumor volume and CT pleural thickness into future staging systems for malignant pleural mesothelioma","volume":"21","author":"O Lauk","year":"2021","journal-title":"Cancer Imaging"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1007\/s00330-018-5533-9","article-title":"Dynamic contrast-enhanced CT for the assessment of tumour response in malignant pleural mesothelioma: a pilot study","volume":"29","author":"E Gudmundsson","year":"2019","journal-title":"Eur Radiol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ejrad.2016.11.009","article-title":"Metabolic response assessment with 18F-FDG-PET\/CT is superior to modified RECIST for the evaluation of response to platinum-based doublet chemotherapy in malignant pleural mesothelioma","volume":"86","author":"S Kanemura","year":"2017","journal-title":"Eur J Radiol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"311","DOI":"10.2214\/ajr.18.20111","article-title":"Whole-Body MRI: Comparison of Its Capability for TNM Staging of Malignant Pleural Mesothelioma With That of Coregistered PET\/MRI, Integrated FDG PET\/CT, and Conventional Imaging","volume":"212","author":"Y Ohno","year":"2019","journal-title":"AJR Am J Roentgenol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1378\/chest.108.4.1122","article-title":"A proposed new international TNM staging system for malignant pleural mesothelioma. From the International Mesothelioma Interest Group","volume":"108","author":"VW Rusch","year":"1995","journal-title":"Chest"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"543","DOI":"10.21037\/tlcr.2018.07.05","article-title":"The eighth TNM classification for malignant pleural mesothelioma","volume":"7","author":"L Berzenji","year":"2018","journal-title":"Transl Lung Cancer Res"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/j.jtho.2024.03.007","article-title":"The International Association for the Study of Lung Cancer Mesothelioma Staging Project: Proposals for Revisions of the \"T\" Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Pleural Mesothelioma","volume":"19","author":"RR Gill","year":"2024","journal-title":"J Thorac Oncol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1016\/j.jtho.2024.05.003","article-title":"The International Association for the Study of Lung Cancer Mesothelioma Staging Project: Proposals for the \"N\" Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Pleural Mesothelioma","volume":"19","author":"A Bille","year":"2024","journal-title":"J Thorac Oncol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1016\/j.jtho.2024.01.018","article-title":"The International Association for the Study of Lung Cancer Pleural Mesothelioma Staging Project: Expanded Database to Inform Revisions in the Ninth Edition of the TNM Classification of Pleural Mesothelioma","volume":"19","author":"AS Wolf","year":"2024","journal-title":"J Thorac Oncol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/j.jtho.2024.05.002","article-title":"The International Association for the Study of Lung Cancer Pleural Mesothelioma Staging Project: Proposal for Revision of the TNM Stage Groupings in the Forthcoming (Ninth) Edition of the TNM Classification for Pleural Mesothelioma","volume":"19","author":"AK Nowak","year":"2024","journal-title":"J Thorac Oncol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1016\/j.jtho.2024.08.022","article-title":"The IASLC Mesothelioma Staging Project: Proposals for the M Descriptors in the Forthcoming 9(th) Edition of the TNM Classification for Pleural Mesothelioma","volume":"19","author":"HL Kindler","year":"2024","journal-title":"J Thorac Oncol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"73","DOI":"10.21037\/shc.2018.09.01","article-title":"Patient selection for radical surgery for mesothelioma\u2014prognostic factors in a multimodality approach","volume":"2","author":"O Lauk","year":"2018","journal-title":"Shanghai Chest"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezac085","article-title":"Prospective validation and extension of the Multimodality Prognostic Score for the treatment allocation of pleural mesothelioma patients","volume":"62","author":"D Greb","year":"2022","journal-title":"Eur J Cardiothorac Surg"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1118\/1.3537610","article-title":"Characterization of mesothelioma and tissues present in contrast-enhanced thoracic CT scans","volume":"38","author":"N Corson","year":"2011","journal-title":"Med Phys"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.lungcan.2005.12.013","article-title":"Modeling of mesothelioma growth demonstrates weaknesses of current response criteria","volume":"52","author":"GR Oxnard","year":"2006","journal-title":"Lung Cancer"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1007\/s00330-018-5887-z","article-title":"Correlation of patient survival with clinical tumor measurements in malignant pleural mesothelioma","volume":"29","author":"F Li","year":"2019","journal-title":"Eur Radiol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1093\/annonc\/mdh059","article-title":"Modified RECIST criteria for assessment of response in malignant pleural mesothelioma","volume":"15","author":"MJ Byrne","year":"2004","journal-title":"Ann Oncol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e652","DOI":"10.1016\/j.cllc.2019.06.019","article-title":"The Prognostic Role of TNM Staging Compared With Tumor Volume and Number of Pleural Sites in Malignant Pleural Mesothelioma","volume":"20","author":"C Proto","year":"2019","journal-title":"Clin Lung Cancer"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s00259-024-06853-0","article-title":"Outcome prediction based on [18F]FDG PET\/CT in patients with pleural mesothelioma treated with ipilimumab and nivolumab +\/- UV1 telomerase vaccine","volume":"52","author":"S Thunold","year":"2025","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s11604-023-01480-5","article-title":"An overview on multimodal imaging for the diagnostic workup of pleural mesothelioma","volume":"42","author":"M Gabelloni","year":"2024","journal-title":"Jpn J Radiol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.acra.2017.03.006","article-title":"Can CT and MR Shape and Textural Features Differentiate Benign Versus Malignant Pleural Lesions?","volume":"24","author":"E Pena","year":"2017","journal-title":"Acad Radiol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s13550-020-00669-3","article-title":"FDG PET versus CT radiomics to predict outcome in malignant pleural mesothelioma patients","volume":"10","author":"M Pavic","year":"2020","journal-title":"EJNMMI Res"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1136\/thoraxjnl-2021-217808","article-title":"Fully automated volumetric measurement of malignant pleural mesothelioma by deep learning AI: validation and comparison with modified RECIST response criteria","volume":"77","author":"AC Kidd","year":"2022","journal-title":"Thorax"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1093\/icvts\/ivab241","article-title":"Extended, virtual and augmented reality in thoracic surgery: a systematic review","volume":"34","author":"A Arjomandi Rad","year":"2022","journal-title":"Interact Cardiovasc Thorac Surg"}],"container-title":["Zentralblatt f\u00fcr Chirurgie - Zeitschrift f\u00fcr Allgemeine, Viszeral-, Thorax- und Gef\u00e4\u00dfchirurgie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2576-6585.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T08:31:57Z","timestamp":1764318717000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2576-6585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":43,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2025,8,25]]},"published-print":{"date-parts":[[2025,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2576-6585","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0044-409X","1438-9592"],"issn-type":[{"type":"print","value":"0044-409X"},{"type":"electronic","value":"1438-9592"}],"subject":[],"published":{"date-parts":[[2025,5,19]]}}}