{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:06:52Z","timestamp":1782209212680,"version":"3.54.5"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>\n                  Background\u2002Lumen-apposing metal stents (LAMSs) are widely used for endoscopic ultrasound (EUS)-guided drainage of pancreatic fluid collections (PFCs). Safety is a major concern and the timing of LAMS removal is debated owing to the risk of adverse events (AEs). Previous studies showed early stent removal was associated with a reduced risk of AEs, but data are still conflicting. The aim of this systematic review with meta-analysis was to identify the optimal timing for LAMS removal.<\/jats:p><jats:p>\n                  Methods\u2002Major databases were systematically searched until May 2024. The outcome assessed was the cumulative incidence of AEs related to the early (within 3\u20134 weeks) versus late (after 3\u20134 weeks) removal of the LAMS. A random-effects (DerSimonian\u2013Laird) model was used to pool the results.<\/jats:p><jats:p>\n                  Results\u2002Eight studies (1820 patients; mean age 54\u201361.6 years; 63\u200a% men) were included in the analysis. PFCs included walled-off necrosis (WON; 58.2\u200a%) and pseudocysts (41.8\u200a%). Pooled LAMS-related AEs rate were similar in the late versus early removal groups (risk ratio [RR] 1.03, 95\u200a%CI 0.47\u20132.28; P\u200a=\u200a0.94). Sensitivity analysis, including only studies applying a 4-week cut-off, confirmed a comparable AEs rate (RR 0.80, 95\u200a%CI 0.38\u20131.65; P\u200a=\u200a0.59). The mean (SD) follow-up of the studies was 208 (88) days. <\/jats:p><jats:p>\n                  Conclusions\u2002The results of this meta-analysis showed no difference in the incidence of AEs between early and late removal of LAMSs in the presence of moderate heterogeneity across studies. Removal within 4 weeks is not warranted, and it may instead be planned on a clinical case-by-case basis according on the patient's condition.<\/jats:p>","DOI":"10.1055\/a-2577-3814","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T19:10:47Z","timestamp":1745953847000},"page":"1023-1033","source":"Crossref","is-referenced-by-count":3,"title":["Optimal timing for lumen-apposing metal stent removal following endoscopic ultrasound-guided drainage of pancreatic fluid collections: a systematic review and meta-analysis"],"prefix":"10.1055","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4992-9289","authenticated-orcid":false,"given":"Marcello","family":"Maida","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, University of Enna \u201cKore\u201d, Enna, Italy"},{"name":"Gastroenterology Unit, Umberto I Hospital, Enna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9335-6740","authenticated-orcid":false,"given":"Giacomo Emanuele Maria","family":"Rizzo","sequence":"first","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Department of Diagnostic and Therapeutic Services, Istituto mediterraneo per i trapianti e terapie ad alta specializzazione, IRCCS-ISMETT, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Traina","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Department of Diagnostic and Therapeutic Services, Istituto mediterraneo per i trapianti e terapie ad alta specializzazione, IRCCS-ISMETT, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9333-0399","authenticated-orcid":false,"given":"John G\u00e1sdal","family":"Karstensen","sequence":"additional","affiliation":[{"name":"Pancreatitis Centre East (PACE), Gastro Unit, Copenhagen University Hospital \u2013 Amager and Hvidovre, Hvidovre, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9969-019X","authenticated-orcid":false,"given":"Rogier P.","family":"Voermans","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8857-3556","authenticated-orcid":false,"given":"Joan B.","family":"Gornals","sequence":"additional","affiliation":[{"name":"Endoscopy Unit, Department of Digestive Diseases, Hospital Universitari de Bellvitge, Barcelona, Spain"},{"name":"Universitat de Barcelona (UB), Barcelona, Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3469-0164","authenticated-orcid":false,"given":"Nitin","family":"Jagtap","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology, Medical Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-0482","authenticated-orcid":false,"given":"Dario","family":"Ligresti","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Department of Diagnostic and Therapeutic Services, Istituto mediterraneo per i trapianti e terapie ad alta specializzazione, IRCCS-ISMETT, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8630-6312","authenticated-orcid":false,"given":"Lucio","family":"Carrozza","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Department of Diagnostic and Therapeutic Services, Istituto mediterraneo per i trapianti e terapie ad alta specializzazione, IRCCS-ISMETT, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Rancatore","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Department of Diagnostic and Therapeutic Services, Istituto mediterraneo per i trapianti e terapie ad alta specializzazione, IRCCS-ISMETT, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ventimiglia","sequence":"additional","affiliation":[{"name":"Directorate General of Medical Devices and Pharmaceutical service of the Italian Ministry of Health, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2107-2156","authenticated-orcid":false,"given":"Antonio","family":"Facciorusso","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Universit\u00e0 del Salento, Lecce, Italy"},{"name":"Clinical Effectiveness Research Group, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Fabbri","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Forl\u00ec-Cesena Hospitals, AUSL Romagna, Forl\u00ec-Cesena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Anderloni","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy, Unit Fondazione IRCCS Policlinico San Matteo, Pavia, Italy"},{"name":"Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8791-3395","authenticated-orcid":false,"given":"Ilaria","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Department of Diagnostic and Therapeutic Services, Istituto mediterraneo per i trapianti e terapie ad alta specializzazione, IRCCS-ISMETT, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the I-EUS group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1007\/s00464-020-07567-8","article-title":"The safety and efficacy of a new 20-mm lumen apposing metal stent (lams) for the endoscopic treatment of pancreatic and peripancreatic fluid collections: a large international, multicenter 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