{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:57:09Z","timestamp":1787068629687,"version":"build-2736575974"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Percutaneous transhepatic biliary drainage (PTBD) and endoscopic ultrasound-guided biliary drainage (EUS-BD), including choledochoduodenostomy (EUS-CDS), are alternative methods for biliary drainage in patients with distal malignant biliary obstruction (MBO) after failed endoscopic retrograde cholangiopancreatography (ERCP). Data on long-term outcomes, adverse events (AEs), and quality of life (QoL) after EUS-CDS and PTBD are limited. Therefore, we created a registry to evaluate the outcomes of both drainage procedures.<\/jats:p>\n                  <jats:p>Patients with distal MBO who underwent EUS-CDS or PTBD after unsuccessful ERCP were included in this multicenter investigator-initiated prospective registry over an 18-month inclusion period. Primary end points were procedure-related AEs and mortality within 90 days post-procedure. Secondary end points included technical and clinical success, reinterventions, hospital stay, and QoL.<\/jats:p>\n                  <jats:p>55 patients were included, with 12 patients undergoing PTBD (technical success 100%) and 43 patients EUS-CDS (technical success 97.7%). Prior to ERCP, 7\/12 patients in the PTBD group and 12\/43 patients in the EUS-CDS group opted for best supportive care. The 90-day mortality rate was 66.7% in the PTBD group and 20.9% in the EUS-CDS group (P = 0.005). Furthermore, 11\/12 patients (91.7%) in the PTBD group and 19\/43 (44.2%) in the EUS-CDS group developed one or more AEs (P = 0.004). The median post-procedural hospital stay was 4 days (interquartile range [IQR] 2\u20136) in the PTBD group vs. 1 day (IQR 1\u20132) in the EUS-CDS group (P = 0.001).<\/jats:p>\n                  <jats:p>When both modalities were available and technically feasible, gastroenterologists preferred EUS-CDS over PTBD. EUS-CDS seems to be associated with lower mortality and AE rates, shorter hospital admission, and fewer reinterventions, but a randomized controlled trial should confirm these observations.<\/jats:p>","DOI":"10.1055\/a-2580-1316","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T19:08:51Z","timestamp":1744312131000},"page":"1004-1015","source":"Crossref","is-referenced-by-count":18,"title":["Endoscopic ultrasound-guided choledochoduodenostomy results in fewer complications than percutaneous drainage following failed ERCP in malignant distal biliary obstruction"],"prefix":"10.1055","volume":"57","clinical-trial-number":[{"clinical-trial-number":"nct05519605","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7738-7206","authenticated-orcid":false,"given":"Mike J.P.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Radboud University Medical Center, 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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina A.","family":"Bijlsma","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Martini Hospital, Groningen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd D.","family":"Kuiken","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6109-9310","authenticated-orcid":false,"given":"Rutger","family":"Quispel","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Reinier de Graaf Gasthuis, Delft, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Hadithi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Maasstad Hospital, Rotterdam, 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