{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T07:06:35Z","timestamp":1764313595947,"version":"3.46.0"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Tier\u00e4rzt*innen werden h\u00e4ufig Tiere mit Hornhautverletzungen vorgestellt. Seit\n                    langem wird Vitamin A in der Behandlung von Hornhautulzerationen eingesetzt, um\n                    die Hornhautwundheilung zu beg\u00fcnstigen. Doch wie ist die Evidenzlage zu dieser\n                    Vorgehensweise? Wird diese durch die vorhandene Literatur unterst\u00fctzt? Um dies\n                    zu beleuchten, wurde in der bisherigen Literatur nach Artikeln gesucht, die\n                    dieses Thema behandeln. Dabei konnte in 12 Artikeln eine nur schwache Evidenz\n                    f\u00fcr eine klinisch relevante, vorteilhafte Wirkung von Vitamin A und seinen\n                    Derivaten auf die Heilung von Hornhautdefekten bei Hund und Katze gefunden\n                    werden. Bisherige Studien behandeln fast ausschlie\u00dflich den Effekt bei kleinen\n                    S\u00e4ugetieren, bei denen die Studienlage gemischt ist. F\u00fcr eine bessere\n                    Beurteilung des potenziell positiven Effektes von Vitamin A und seinen Derivaten\n                    bei Hund und Katze bedarf es prospektiver, multizentrischer Studien bei Tieren\n                    mit Hornhautulzerationen. Eine klinisch relevante Wirkung konnte nur bei 2\n                    Studien bei kleinen S\u00e4ugetieren festgestellt werden, die einzige bisher beim\n                    Hund durchgef\u00fchrte Studie konnte keinen positiven Effekt auf die Wundheilung\n                    zeigen. Daher sollte die Gabe von Vitamin A als zus\u00e4tzliches Medikament bei\n                    Hornhautulzerationen sorgsam bedacht werden, da Ressourcen und Compliance der\n                    Besitzer*innen durch zus\u00e4tzliche Medikamente negativ beeinflusst werden k\u00f6nnen.\n                    Die Gabe essenzieller Medikamente sollte im Vordergrund stehen.<\/jats:p>","DOI":"10.1055\/a-2582-3677","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T18:52:05Z","timestamp":1749840725000},"page":"159-166","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin A bei Hornhautdefekten von Hund und Katze"],"prefix":"10.1055","volume":"53","author":[{"given":"Merle","family":"Grei\u00df","sequence":"additional","affiliation":[{"name":"Abteilung Ophthalmologie, Klinik f\u00fcr Kleintiere, Stiftung Tier\u00e4rztliche\n                    Hochschule Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Busse","sequence":"additional","affiliation":[{"name":"Abteilung Ophthalmologie, Klinik f\u00fcr Kleintiere, Stiftung Tier\u00e4rztliche\n                    Hochschule Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1055\/b-004-140269","volume-title":"Kapitel 17, Augenkrankheiten. In: Kohn B, Schwarz G, Hrsg. Praktikum der\n                    Hundeklinik, ed. 12., aktualisierte Aufl","author":"B Nell","year":"2017"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"431","DOI":"10.4103\/sja.sja_158_21","article-title":"Statistical significance or clinical significance? A researcher\u2019s dilemma for\n                    appropriate interpretation of research results","volume":"15","author":"H Sharma","year":"2021","journal-title":"Saudi J Anaesth"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.2147\/OPTH.S52280","article-title":"The role of topical vitamin A in promoting healing in surface refractive\n                    procedures: a prospective randomised controlled study","volume":"7","author":"E Chelala","year":"2013","journal-title":"Clin Ophthalmol"},{"key":"ref6","first-page":"1671","article-title":"Response of ocular surface epithelium to corneal wounding in retinol-deficient\n                    rabbits","volume":"29","author":"M El-Ghorab","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.2147\/OPTH.S35584","article-title":"Efficacy of retinol palmitate eye drops for dry eye in rabbits with lacrimal\n                    gland resection","volume":"6","author":"A Odaka","year":"2012","journal-title":"Clin Ophthalmol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0002-9394(14)78305-9","article-title":"Healing of experimental corneal wounds treated with topically applied\n                    retinoids","volume":"95","author":"J L Ubels","year":"1983","journal-title":"Am J Ophthalmol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.3109\/02713688509003350","article-title":"The efficacy of retinoic acid ointment for treatment of xerophthalmia and\n                    corneal epithelial wounds. 1985","volume":"4","author":"J L Ubels","year":"2009","journal-title":"Curr Eye Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1055\/s-2008-1050323","article-title":"Tierexperimentelle Untersuchungen zur Frage der Behandlung von\n                    Hornhautl\u00e4sionen","volume":"190","author":"S Niedermeier","year":"1987","journal-title":"Klin Monbl Augenheilkd"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1034\/j.1600-0420.1998.760403.x","article-title":"The healing effect of all-trans retinoic acid on epithelial corneal abrasions in\n                    rabbits","volume":"76","author":"S Johansen","year":"1998","journal-title":"Acta Ophthalmol Scand"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/02713680701827696","article-title":"Effect of retinol palmitate eye drops on experimental keratoconjunctival\n                    epithelial damage induced by n-heptanol in rabbit","volume":"33","author":"H Toshida","year":"2008","journal-title":"Curr Eye Res"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s00417-011-1849-8","article-title":"Effects of all-trans retinoic acid nanoparticles on corneal epithelial wound\n                    healing","volume":"250","author":"M Hattori","year":"2012","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"57","DOI":"10.21608\/jmh.2017.1020.1014","article-title":"Role of vitamin A in the healing process of alkali caused corneal injury of\n                    adult male albino rat: Histological and immunohistochemical study","volume":"1","author":"SAE K Abdelwahab","year":"2017","journal-title":"J Med Histol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e540","DOI":"10.1111\/j.1755-3768.2012.02496.x","article-title":"The wound healing effects of vitamin A eye drops after a corneal alkali burn in\n                    rats","volume":"90","author":"E C Kim","year":"2012","journal-title":"Acta Ophthalmol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1002\/ncp.10420","article-title":"Vitamin A and wound healing","volume":"34","author":"R Zinder","year":"2019","journal-title":"Nutr Clin Pract"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1055\/b-005-145219","volume-title":"Teil IV Energie, Energiestoffwechsel, Metabolismus. In: Kues W, von\n                    K\u00f6ckritz-Blickwede M, Hrsg. Biochemie f\u00fcr die Tiermedizin. ed. 1. Aufl","author":"K Branitzki-Heinemann","year":"2020"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1097\/IJG.0b013e3181f7b10e","article-title":"Prevalence and correlates of self-reported nonadherence with eye drop\n                    treatment","volume":"20","author":"S Vandenbroeck","journal-title":"J Glaucoma"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1097\/00000658-196803000-00004","article-title":"Effects of cortisone and vitamin A on wound healing","volume":"167","author":"H P Ehrlich","year":"1968","journal-title":"Ann Surg"}],"container-title":["Tier\u00e4rztliche Praxis Ausgabe K: Kleintiere \/ Heimtiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2582-3677.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T07:02:02Z","timestamp":1764313322000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2582-3677"}},"subtitle":["Literaturrecherche offenbart schwache Evidenz f\u00fcr die\n                    Heilungsf\u00f6rderung"],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":17,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2025,6,13]]},"published-print":{"date-parts":[[2025,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2582-3677","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1434-1239","2567-5842"],"issn-type":[{"type":"print","value":"1434-1239"},{"type":"electronic","value":"2567-5842"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}