{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T21:41:16Z","timestamp":1788644476973,"version":"build-2803163510"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To evaluate the significance of high-resolution ultrasound (HRUS) and shear wave elastography (SWE) in the diagnosis of diabetic peripheral neuropathy (DPN) to clarify their possible roles as early predictors of the occurrence of this important complication.<\/jats:p>\n                  <jats:p>The study included 90 patients with diabetes mellitus with different clinical stages of DPN as well as 30 healthy controls. A full history, clinical examination, and assessment of both the Toronto Clinical Neuropathy Score (TCNS) and HbA1c were performed, followed by real-time HRUS and SWE examinations of their right and left tibial and median nerves to assess their cross-sectional area (CSA) and nerve stiffness, respectively.<\/jats:p>\n                  <jats:p>The CSA and stiffness of tibial and median nerves were significantly increased in patients with diabetes compared to controls, with higher values associated with the severity of their DPN. Both parameters were correlated with each other and with the duration of the disease, TCNS, and HbA1c. The CSA cut-off value of both tibial and median nerves to detect DPN in patients was 13.5 mm2, meanwhile, the SWE cut-off values were 68.5 and 61.5 KPa, respectively. SWE showed a higher AUC than CSA for the prediction of DPN.<\/jats:p>\n                  <jats:p>Measurement of the CSA and stiffness of the peripheral nerves could be a reliable tool for early detection of DPN. Therefore, we recommend adding these noninvasive diagnostic parameters as complementary diagnostic tools to the routine follow-up schedule of diabetic complications, especially in long-standing cases.<\/jats:p>","DOI":"10.1055\/a-2589-8675","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T18:50:03Z","timestamp":1746471003000},"page":"407-416","source":"Crossref","is-referenced-by-count":3,"title":["Significance of high-resolution ultrasound imaging and elastography as early predictors of diabetic peripheral neuropathy"],"prefix":"10.1055","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7913-396X","authenticated-orcid":false,"given":"Ahmed","family":"Elshimy","sequence":"additional","affiliation":[{"name":"Ain Shams University Faculty of Medicine, Egypt","place":["Cairo"],"department":["Radiology Department"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada","family":"Elshimy","sequence":"additional","affiliation":[{"name":"Augusta University Medical College of Georgia, Georgia, United States","place":["Augusta"],"department":["Endocrinology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4059-753X","authenticated-orcid":false,"given":"Ahmed Mohamed","family":"Abouelhoda","sequence":"additional","affiliation":[{"name":"Ain Shams University Faculty of Medicine, Egypt","place":["Cairo"],"department":["Radiology Department"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Abdellatif","family":"Awad","sequence":"additional","affiliation":[{"name":"Ain Shams University Faculty of Medicine, Egypt","place":["Cairo"],"department":["Physical Medicine, Rheumatology and Rehabilitation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7517-4641","authenticated-orcid":false,"given":"Omar","family":"Farouk","sequence":"additional","affiliation":[{"name":"Ain Shams University Faculty of Medicine, Egypt","place":["Cairo"],"department":["Radiology Department"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"issue":"10","key":"ref3","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/s11892-019-1212-8","article-title":"Epidemiology of peripheral neuropathy and lower extremity disease in diabetes","volume":"19","author":"CW Hick","year":"2019","journal-title":"Curr Diab Rep"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"246","DOI":"10.15557\/JoU.2017.0036","article-title":"High resolution ultrasonography of the tibial nerve in diabetic peripheral neuropathy","volume":"17","author":"K Singh","year":"2017","journal-title":"J Ultrason"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"717","DOI":"10.3233\/BMR-160676","article-title":"Diabetic peripheral neuropathy: Correlation between nerve cross-sectional area on ultrasound and clinical features","volume":"29","author":"B Kelle","year":"2016","journal-title":"J Back Musculoskelet Rehabil"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s43055-022-00779-z","article-title":"Diagnostic value of shear wave ultrasound elastography of tibial nerve in patients with diabetic peripheral neuropathy","volume":"53","author":"HR Ibrahim","year":"2022","journal-title":"Egypt J Radiol Nucl Med"},{"issue":"10","key":"ref7","doi-asserted-by":"publisher","first-page":"4308","DOI":"10.3390\/app14104308","article-title":"Ultrasound Elastography: Methods, Clinical Applications, and Limitations: A Review Article","volume":"14","author":"AA Oglat","year":"2024","journal-title":"Appl. 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