{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:22:35Z","timestamp":1768807355999,"version":"3.49.0"},"reference-count":54,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obstructive sleep apnea (OSA) is a widespread condition associated with an elevated risk of adverse outcomes. Continuous positive airway pressure (CPAP) is the gold standard treatment, particularly for moderate to severe OSA. However, in many instances, CPAP compliance falls short of expectations, necessitating physicians to consider additional interventions to alleviate patient symptoms. A comprehensive understanding of OSA endotypes and phenotypes can potentially enhance the confidence in selecting the appropriate combination or intervention to improve patient care. In this review, we will discuss various interventions and medications available to enhance the treatment of patients with OSA, following a precision medicine approach.<\/jats:p>","DOI":"10.1055\/a-2591-5502","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T18:41:32Z","timestamp":1748025692000},"page":"125-133","source":"Crossref","is-referenced-by-count":0,"title":["Precision Medicine to Guide Obstructive Sleep Apnea Treatment Beyond the Continuous Positive Airway Pressure"],"prefix":"10.1055","volume":"46","author":[{"given":"Gonzalo","family":"Labarca","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Division of Pulmonary, Allergy, and Sleep Medicine, Mayo Clinic, Jacksonville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Henr\u00edquez-Beltr\u00e1n","sequence":"additional","affiliation":[{"name":"Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova-Santa Maria, Biomedical Research Institute of Lleida (IRBLleida), Lleida, Spain"},{"name":"CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain"},{"name":"N\u00facleo de Investigaci\u00f3n en Ciencias de la Salud, Universidad Adventista de Chile, Chill\u00e1n, Chile"},{"name":"Escuela de Kinesiolog\u00eda, Facultad de Salud, Universidad Santo Tom\u00e1s, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Solomons","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, 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