{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T23:35:40Z","timestamp":1765323340496,"version":"3.46.0"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"name":"Pediatric College, Shanghai Jiao Tong University School of Medicine","award":["ELYZX 202202"],"award-info":[{"award-number":["ELYZX 202202"]}]},{"name":"Shanghai Shenkang Hospital Development Center","award":["SHDC2020CR2063B"],"award-info":[{"award-number":["SHDC2020CR2063B"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The study aimed to combine prenatal risk factors associated with early survival of patients with prenatally diagnosed congenital diaphragmatic hernia (CDH) into a predictive nomogram.<\/jats:p>\n                  <jats:p>We retrospectively analyzed 217 neonates with prenatally diagnosed CDH. The patients who underwent surgery in an earlier period comprised the training cohort (n\u2009=\u2009158) for nomogram development, while those who underwent surgery subsequently constituted the validation cohort (n\u2009=\u200959) to verify the model's performance. The survival rate at discharge was regarded as the primary outcome. Multivariate Logistic analysis was performed, and a nomogram was developed using data from the training cohort. The performance of the nomogram was determined. We also evaluated the nomogram's performance in the independent validation cohorts.<\/jats:p>\n                  <jats:p>On multiple analyses, independent factors for early survival were O\/E LHR, presence of liver herniation, and gestational age at diagnosis, which were all selected into the nomogram. The nomogram had good discrimination with an area under the receiver operator curve of 0.875 (95% confidence interval [CI]: 0.819\u20130.930). The nomogram was calibrated to predict survival in the best possible way compared with the actual results. Using the decision curve analysis, the nomogram was proved to be useful in clinical practice. In the validation cohort, the nomogram model was also found with good discrimination with an area under the receiver operator curve of 0.917 (95% CI: 0.847\u20130.986).<\/jats:p>\n                  <jats:p>The proposed nomogram incorporating prenatal risk factors offered an individualized predictive tool for early survival of patients with CDH, which will help guide prenatal counseling and perinatal management.<\/jats:p>","DOI":"10.1055\/a-2592-0474","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:04:13Z","timestamp":1745435053000},"page":"082-088","source":"Crossref","is-referenced-by-count":0,"title":["A Nomogram Model for Prenatal Predicting Survival in Infants with Congenital Diaphragmatic Hernia"],"prefix":"10.1055","volume":"43","author":[{"given":"Weipeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Intensive Care Unit, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3455-0302","authenticated-orcid":false,"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"},{"name":"Department of Pediatric Surgery, Hangzhou Children's Hospital, Hangzhou, Zhejiang, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.23736\/S0026-4946.18.05186-1","article-title":"Antenatal management of congenital diaphragmatic hernia today and tomorrow","volume":"70","author":"L van der Veeken","year":"2018","journal-title":"Minerva Pediatr"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.jpedsurg.2015.10.082","article-title":"Prenatally diagnosed severe CDH: mortality and morbidity remain high","volume":"51","author":"M A Coughlin","year":"2016","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"51163","DOI":"10.1053\/j.semperi.2019.07.002","article-title":"Prenatal diagnosis, imaging, and prognosis in congenital diaphragmatic hernia","volume":"44","author":"A G Cordier","year":"2020","journal-title":"Semin Perinatol"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"151165","DOI":"10.1053\/j.semperi.2019.07.004","article-title":"Prediction tools in congenital diaphragmatic hernia","volume":"44","author":"T Jancelewicz","year":"2020","journal-title":"Semin Perinatol"},{"issue":"02","key":"ref5","first-page":"218","article-title":"The survivorship bias in congenital diaphragmatic hernia","volume":"9","author":"E Aydin","year":"2022","journal-title":"Children (Basel)"},{"issue":"14","key":"ref6","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1080\/14767058.2019.1664464","article-title":"Predictive value of gestational age at diagnosis for outcomes in prenatally diagnosed congenital diaphragmatic hernia","volume":"34","author":"W Wang","year":"2021","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2147\/JIR.S348490","article-title":"Establishment and effectiveness evaluation of a scoring system-RAAS (RDW, AGE, APACHE II, SOFA) for sepsis by a retrospective analysis","volume":"15","author":"Y Huang","year":"2022","journal-title":"J Inflamm Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"559389","DOI":"10.3389\/fped.2020.559389","article-title":"A nomogram model identifies eosinophilic frequencies to powerfully discriminate Kawasaki disease from febrile infections","volume":"8","author":"X P Liu","year":"2020","journal-title":"Front Pediatr"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/uog.11065","article-title":"Lung-to-head ratio: a need to unify the technique","volume":"39","author":"J C Jani","year":"2012","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.jpedsurg.2013.03.011","article-title":"Congenital diaphragmatic hernia: defect size correlates with developmental defect","volume":"48","author":"F Morini","year":"2013","journal-title":"J Pediatr Surg"},{"issue":"26","key":"ref11","doi-asserted-by":"crossref","first-page":"10613","DOI":"10.1080\/14767058.2022.2145877","article-title":"Development and internal validation of a prediction model to predict survival for congenital diaphragmatic hernia in the early postnatal period","volume":"35","author":"W Pan","year":"2022","journal-title":"J Matern 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Surg"},{"issue":"05","key":"ref21","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00383-015-3695-y","article-title":"Outcome of right-sided diaphragmatic hernia repair: a multicentre study","volume":"31","author":"J W Duess","year":"2015","journal-title":"Pediatr Surg Int"},{"issue":"08","key":"ref22","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/pd.5706","article-title":"Is laterality of congenital diaphragmatic hernia a reliable prognostic factor? French national cohort study","volume":"40","author":"A Pinton","year":"2020","journal-title":"Prenat Diagn"},{"issue":"06","key":"ref23","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/uog.13223","article-title":"Fetal lung volume and quantification of liver herniation by magnetic resonance imaging in isolated congenital diaphragmatic hernia","volume":"43","author":"R Ruano","year":"2014","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"907724","DOI":"10.3389\/fped.2022.907724","article-title":"Mediastinal shift angle in fetal MRI is associated with prognosis, severity, and cardiac underdevelopment in left congenital diaphragmatic hernia","volume":"10","author":"X Wang","year":"2022","journal-title":"Front Pediatr"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2592-0474.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T23:34:27Z","timestamp":1765323267000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2592-0474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,23]]},"references-count":24,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2025,12,9]]},"published-print":{"date-parts":[[2026,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2592-0474","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"type":"print","value":"0735-1631"},{"type":"electronic","value":"1098-8785"}],"subject":[],"published-other":{"date-parts":[[2025,4,23]]},"published":{"date-parts":[[2025,4,23]]}}}