{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T23:40:05Z","timestamp":1746747605078,"version":"3.40.5"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>While resting heart rate (RHR) is associated with multiple diseases, conflicting information exists on the association between RHR and venous thromboembolism (VTE). We, therefore, aimed to investigate the association between RHR and risk of VTE in a population-based cohort.<\/jats:p><jats:p>Participants (n\u2009=\u200936,395) were followed from inclusion in the Troms\u00f8 4 to 7 surveys (1994\u20132016) throughout 2020. RHR was measured in beats per minute (bpm) at each survey (repeated measurements for those attending several surveys). All first-time VTEs during follow-up were recorded. Hazard ratios (HR) for VTE with 95% confidence intervals (CIs) according to RHR categories (61\u201370, 71\u201380, and &gt;80\u2009bpm) with \u226460\u2009bpm as reference were estimated using Cox regression models, and adjusted for age, sex, body mass index, cardiovascular disease, cancer, and physical activity. We also performed age-stratified analyses (&lt;60 and \u226560 years).<\/jats:p><jats:p>During a median of 6.6 years of follow-up, 1,072 participants experienced a VTE. Fully adjusted HRs (95% CI) for overall VTE were 1.12 (0.93\u20131.35), 1.35 (1.11\u20131.63), and 1.19 (0.97\u20131.47) for RHR categories 61 to 70, 71 to 80, and &gt;80\u2009bpm, respectively. Corresponding HRs for unprovoked VTE were 1.56 (1.14\u20132.14), 1.76 (1.28\u20132.43), and 1.60 (1.13\u20132.25), whereas no association was observed for provoked VTE. The association was more consistent in those \u226560 years, with HRs for overall VTE, &gt;80\u2009bpm versus \u226460\u2009bpm of 1.30 (1.02\u20131.65) and for unprovoked VTE of 1.86 (1.24\u20132.81).<\/jats:p><jats:p>Our findings suggest that higher RHR may be a risk factor for VTE and more consistently so for those \u226560 years. The VTE risk by higher RHR was particularly pronounced for unprovoked events.<\/jats:p>","DOI":"10.1055\/a-2593-1679","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T22:51:53Z","timestamp":1745535113000},"source":"Crossref","is-referenced-by-count":0,"title":["Resting Heart Rate and Risk of Incident Venous Thromboembolism: The Troms\u00f8 Study"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6583-2914","authenticated-orcid":false,"given":"Oda G.R.","family":"Leknessund","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Thrombosis Research Group, UiT\u2014the Arctic University of Norway, Troms, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John-Bjarne","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Thrombosis Research Group, UiT\u2014the Arctic University of Norway, Troms, Norway"},{"name":"Division of Internal Medicine, Thrombosis Research Center, University Hospital of North Norway, Troms, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid K.","family":"Br\u00e6kkan","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Thrombosis Research Group, UiT\u2014the Arctic University of Norway, Troms, Norway"},{"name":"Division of Internal Medicine, Thrombosis Research Center, University Hospital of North Norway, Troms, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(20)32658-1","article-title":"Venous thromboembolism","volume":"398","author":"F Khan","year":"2021","journal-title":"Lancet"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1186\/s40064-016-2949-z","article-title":"Health-related quality of life after deep vein 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