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Their structures were established through a comprehensive analysis of HRMS and 1D and 2D\u2009NMR data, while the absolute configurations were determined using the Mo2(OAc)4-induced circular dichroism (ICD), ECD, and NMR calculations. Compound 1 attenuated the secretion of NO, TNF-\u03b1, and IL-6, downregulated the protein expression of COX-2 and iNOS, and inhibited the release of ROS in LPS-induced RAW264.7 macrophages. Further investigation revealed that the anti-inflammatory effects may be attributed to the inhibition of the NF-\u03baB and NLRP3 signaling pathways.<\/jats:p>","DOI":"10.1055\/a-2596-3029","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T18:49:42Z","timestamp":1745866182000},"page":"576-589","source":"Crossref","is-referenced-by-count":2,"title":["Polycyclic Polyprenylated Acylphloroglucinols from Hypericum himalaicum"],"prefix":"10.1055","volume":"91","author":[{"given":"Guang-Hui","family":"Liu","sequence":"first","affiliation":[{"name":"Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P.\u200aR. China"},{"name":"University of Chinese Academy of Sciences, Beijing, P.\u200aR. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wu","sequence":"first","affiliation":[{"name":"Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P.\u200aR. China"},{"name":"University of Chinese Academy of Sciences, Beijing, P.\u200aR. China"},{"name":"Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, P.\u200aR. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Yan","family":"Huo","sequence":"first","affiliation":[{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, P.\u200aR. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Bing","family":"Sun","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P.\u200aR. China"},{"name":"University of Chinese Academy of Sciences, Beijing, P.\u200aR. China"},{"name":"Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, P.\u200aR. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo-Lin","family":"Jin","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P.\u200aR. China"},{"name":"University of Chinese Academy of Sciences, Beijing, P.\u200aR. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Cheng","family":"Gu","sequence":"additional","affiliation":[{"name":"Syngenta Jealott\u02bcs Hill International Research Centre, Bracknell, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Le","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, P.\u200aR. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P.\u200aR. 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