{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:23:51Z","timestamp":1767659031831,"version":"3.48.0"},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to examine whether newborns with orofacial clefts are at increased prevalence of poor birth health outcomes.<\/jats:p>\n                  <jats:p>This is a population-based cross-sectional study, conducted with information from 25,879,282 live births registered in the U.S. Vital Statistics Natality Birth Data from 2017 to 2023. The prevalence ratios and logistic regression models between orofacial cleft status (all, isolated, or nonisolated) and each child's birth health variables (delivery method, maternal morbidity, 5-minute Apgar score, gestational age, birth weight, abnormal conditions, infant breastfed at discharge) were calculated, assuming a p \u2264 0.05 as statistically significant.<\/jats:p>\n                  <jats:p>The prevalence ratios showed that newborns with orofacial clefts were more susceptible to being born by cesarean section (prevalence ratio [PR]\u2009=\u20091.18, p\u2009=\u20090.000, 95% confidence interval [CI]\u2009=\u20091.16\u20131.21), having lower birth weight (PR\u2009=\u20092.18, p\u2009=\u20090.000, 95% CI\u2009=\u20092.11\u20132.25), lower Apgar 5 score (PR\u2009=\u20094.08, p\u2009=\u20090.000, 95% CI\u2009=\u20094.08\u20134.50), prematurity (PR\u2009=\u20091.55, p\u2009=\u20090.000, 95% CI\u2009=\u20091.50\u20131.60), experiencing more abnormal conditions at birth (PR\u2009=\u20093.72, p\u2009=\u20090.000, 95% CI\u2009=\u20093.64\u20133.80), and having more difficulty to be breastfed (PR\u2009=\u20092.16, p\u2009=\u20090.000, 95% CI\u2009=\u20092.11\u20132.22) than newborns without clefts. These ratios were even higher among those with nonisolated orofacial clefts. Associations were statistic significant even after adjustments.<\/jats:p>\n                  <jats:p>This study provides evidence that newborns with orofacial clefts are at increased prevalence of poor birth health outcomes.<\/jats:p>","DOI":"10.1055\/a-2598-9487","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T19:18:08Z","timestamp":1747855088000},"page":"180-188","source":"Crossref","is-referenced-by-count":1,"title":["Orofacial Cleft and Poor Birth Health Outcomes: A Populational Cross-Sectional Study"],"prefix":"10.1055","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-6970","authenticated-orcid":false,"given":"Adriana Mendon\u00e7a da","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Health, State University of Feira de Santana, Feira de Santana, BA, Brazil"},{"name":"Arizona School of Dentistry and Oral Health, A. T. Still University, Mesa, Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria Souza","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Health, State University of Feira de Santana, Feira de Santana, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Rezende","family":"Vieira","sequence":"additional","affiliation":[{"name":"Arizona School of Dentistry and Oral Health, A. T. Still University, Mesa, Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60695-4","article-title":"Cleft lip and palate","volume":"374","author":"P A Mossey","year":"2009","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"108373","DOI":"10.1016\/j.mrrev.2021.108373","article-title":"Orofacial clefts embryology, classification, epidemiology, and genetics","volume":"787","author":"G Nasreddine","year":"2021","journal-title":"Mutat Res Rev Mutat Res"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.clp.2018.07.006","article-title":"Cleft lip and palate","volume":"45","author":"M L Worley","year":"2018","journal-title":"Clin Perinatol"},{"key":"ref4","first-page":"13","volume-title":"The burden of orofacial clefts: global trends and 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