{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T23:11:57Z","timestamp":1778022717273,"version":"3.51.4"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to investigate the association between objective and subjective olfactory assessments in patients with recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection undergoing endoscopic endonasal skull base surgery (EESBS).<\/jats:p>\n                  <jats:p>Retrospective cohort study.<\/jats:p>\n                  <jats:p>Academic medical center.<\/jats:p>\n                  <jats:p>Adult patients with and without recent SARS-CoV-2 infection who underwent EESBS for sellar and parasellar lesion resection between 2020 and 2024 at the Mayo Clinic in Florida, Jacksonville, FL.<\/jats:p>\n                  <jats:p>Pre- and postoperative self-reported olfactory dysfunction and University of Pennsylvania Smell Identification Test (UPSIT) scores were collected.<\/jats:p>\n                  <jats:p>Patients with recent SARS-CoV-2 infection had a similar rate of discrepant preoperative objective olfactory assessments (38.2%, 26\/68) compared with SARS-CoV-2-negative patients (39.9%, 127\/318). SARS-CoV-2-positive patients were twice as likely to report postoperative subjective olfactory dysfunction (46.2%, 12\/26) compared with SARS-CoV-2-negative patients (18.1%, 23\/127, p\u2009=\u20090.002). There was no statistically significant difference in the mean preoperative (p\u2009=\u20090.162) or postoperative (p\u2009=\u20090.724) UPSIT scores between both groups.<\/jats:p>\n                  <jats:p>Patients with recent SARS-CoV-2 infection and discrepant preoperative objective olfactory assessments were twice as likely to self-report olfactory dysfunction following EESBS compared with SARS-CoV-2-negative controls. This increase in self-reported olfactory dysfunction was not accompanied by changes in objective psychophysical testing. These findings suggest that SARS-CoV-2 infection may impact subjective olfactory recovery following EESBS.<\/jats:p>","DOI":"10.1055\/a-2599-4262","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T18:39:44Z","timestamp":1748025584000},"page":"345-351","source":"Crossref","is-referenced-by-count":0,"title":["Association between Objective and Subjective Olfactory Dysfunction in SARS-CoV-2-Positive Patients Undergoing Skull Base Surgery"],"prefix":"10.1055","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1957-7892","authenticated-orcid":false,"given":"Bastien A.","family":"Valencia-Sanchez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Mayo Clinic Florida, Jacksonville, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0277-4100","authenticated-orcid":false,"given":"Prishae","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Mayo Clinic Florida, Jacksonville, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha N.","family":"Najmi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Mayo Clinic Florida, Jacksonville, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Alhalabi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Mayo Clinic Florida, Jacksonville, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaisorn","family":"Chaichana","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Mayo Clinic Florida, Jacksonville, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela M.","family":"Donaldson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, Mayo Clinic Florida, Jacksonville, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1001\/jamaneurol.2022.0154","article-title":"Postmortem assessment of olfactory tissue degeneration and microvasculopathy in patients with COVID-19","volume":"79","author":"C Y Ho","year":"2022","journal-title":"JAMA 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