{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:34:28Z","timestamp":1790699668479,"version":"4.1.0"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"name":"Fund of \u201cSanming\u201d Project of Medicine in Shenzhen","award":["SZSM201911017"],"award-info":[{"award-number":["SZSM201911017"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["3332022123"],"award-info":[{"award-number":["3332022123"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen Key Medical Discipline Construction Fund","award":["SZXK001"],"award-info":[{"award-number":["SZXK001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The association between matrix Gla protein (MGP) and vascular calcification has been investigated in recent years; however, studies focusing on MGP with plaque calcification are lacking. In the present study, we aimed to explore the association of circulating and regional levels, as well as polymorphism of MGP with plaque calcification detected by optical coherence tomography (OCT) and adverse clinical outcome in patients with ST-segment elevation myocardial infarction (STEMI).<\/jats:p>\n                  <jats:p>A prospective cohort of 1,648 consecutive patients with STEMI were established. Circulating level of dephosphorylated-uncarboxylated MGP (dp-ucMGP) was determined using enzyme-linked immunosorbent assay. The primary outcome was major adverse cardiovascular event (MACE), composite of all-cause death, recurrent myocardial infarction, and ischemic stroke. Plaque calcification of 326 patients in the cohort was analyzed via OCT and MGP single nucleotide polymorphism (SNP) was detected in 1,313 patients. A total of 54 patients with aspirated coronary material undertook immunohistochemical (IHC) staining for quantifying regional MGP expression surrounding culprit lesions. During a median follow-up of 4 years, patients with high dp-ucMGP (\u22651128\u2009ng\/mL) were associated with higher risk of death (hazard ratio [HR]: 1.41, 95% confidence interval [CI]: 1.02\u20131.97, p\u2009=\u20090.040), which was sustained in propensity score matching (HR: 1.488, 95% CI: 1.049\u20132.109, p\u2009=\u20090.026). In OCT observation, patients with annular calcification had higher level of dp-ucMGP than those without calcification (1,273\u2009ng\/mL [972.2\u20132168] vs. 1,079\u2009ng\/mL [729.2\u20131888], p\u2009=\u20090.0136). On IHC examination, patients with culprit plaque calcifications had significantly higher regional MGP expression than those without in their aspirated coronary material (AOD: 0.225\u2009\u00b1\u20090.021 vs. 0.183\u2009\u00b1\u20090.021, p\u2009&lt;\u20090.0001). However, MGP variants showed no correlation with plaque calcification or the prognosis of patients in the cohort.<\/jats:p>\n                  <jats:p>High levels of circulating dp-ucMGP were significantly associated with increased mortality and annular plaque calcification in patients with STEMI. Moreover, higher expression of regional MGP in aspirated coronary material showed more indicative value for patients with culprit lesion calcification. However, MGP variants including rs4236, rs1800801, and rs1800802 in the current study were not significantly correlated with plaque calcification or poorer prognosis.<\/jats:p>","DOI":"10.1055\/a-2599-9386","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T18:44:01Z","timestamp":1748025841000},"page":"537-549","source":"Crossref","is-referenced-by-count":2,"title":["Circulating and Regional Matrix Gla Protein Indicating Plaque Calcification and Prognosis of Patients with ST-Segment Elevation Myocardial Infarction"],"prefix":"10.1055","volume":"126","author":[{"given":"Jiannan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1139-495X","authenticated-orcid":false,"given":"Runzhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Department of Cardiovascular Medicine, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2031-6438","authenticated-orcid":false,"given":"Hongbing","family":"Yan","sequence":"additional","affiliation":[{"name":"Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, China"},{"name":"Coronary Heart Disease Center, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanjun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Coronary Heart Disease Center, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/BF00301683","article-title":"Coronary arterial calcification as an active process: a new perspective on an old problem","volume":"54","author":"T M Doherty","year":"1994","journal-title":"Calcif Tissue Int"},{"issue":"06","key":"ref2","first-page":"1764","article-title":"Matrix Gla protein synthesis and gamma-carboxylation in the aortic vessel wall and proliferating vascular smooth muscle cells\u2014a cell system which resembles the system in bone cells","volume":"82","author":"R Wallin","year":"1999","journal-title":"Thromb Haemost"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3390\/ijms20030628","article-title":"Association of the inactive circulating matrix Gla protein with vitamin K intake, calcification, mortality, and cardiovascular disease: a review","volume":"20","author":"S Roumeliotis","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"08","key":"ref4","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1161\/01.ATV.0000173313.46222.43","article-title":"Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification","volume":"25","author":"L J Schurgers","year":"2005","journal-title":"Arterioscler Thromb Vasc 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Zwakenberg","year":"2020","journal-title":"Clin Nutr"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1160\/TH03-08-0572","article-title":"Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography","volume":"91","author":"S Jono","year":"2004","journal-title":"Thromb Haemost"},{"issue":"19","key":"ref9","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.jacc.2013.05.071","article-title":"In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography","volume":"62","author":"H Jia","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for 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Wang","year":"2013","journal-title":"Circ Cardiovasc Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.clinbiochem.2020.05.005","article-title":"Uncarboxylated matrix Gla-protein: a biomarker of vitamin K status and cardiovascular risk","volume":"83","author":"T Jespersen","year":"2020","journal-title":"Clin Biochem"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.maturitas.2013.10.008","article-title":"Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease","volume":"77","author":"E G van den Heuvel","year":"2014","journal-title":"Maturitas"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/HYPERTENSIONAHA.115.05177","article-title":"Inactive matrix Gla-protein is associated with arterial stiffness in an adult population-based study","volume":"66","author":"E Pivin","year":"2015","journal-title":"Hypertension"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/21623945.2020.1721692","article-title":"Matrix Gla protein regulates adipogenesis and is serum marker of visceral adiposity","volume":"9","author":"C Li","year":"2020","journal-title":"Adipocyte"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s40200-022-01180-3","article-title":"Inactive matrix Gla protein in relation to diabetic retinopathy in type 2 diabetes","volume":"22","author":"H Adel","year":"2023","journal-title":"J Diabetes Metab Disord"},{"issue":"02","key":"ref18","first-page":"84","article-title":"Undercarboxylated matrix Gla protein in patients with ST-segment elevation myocardial infarction and chronic coronary syndromes","volume":"16","author":"E Konduracka","year":"2021","journal-title":"Folia 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Herrmann","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"03","key":"ref34","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/ATVBAHA.112.300491","article-title":"Matrix gla protein gene polymorphism is associated with increased coronary artery calcification progression","volume":"33","author":"A E Cassidy-Bushrow","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"04","key":"ref35","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000302722","article-title":"Vascular calcification and cardiovascular outcome in dialysis patients: the role of gene polymorphisms","volume":"29","author":"M Cozzolino","year":"2010","journal-title":"Blood Purif"},{"issue":"06","key":"ref36","doi-asserted-by":"crossref","first-page":"e0235122","DOI":"10.1371\/journal.pone.0235122","article-title":"Matrix Gla protein polymorphism rs1800801 associates with recurrence of ischemic stroke","volume":"15","author":"P Hendrix","year":"2020","journal-title":"PLoS One"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.jdiacomp.2017.06.012","article-title":"Matrix Gla protein T-138C polymorphism is associated with carotid intima media thickness and predicts mortality in patients with diabetic nephropathy","volume":"31","author":"S Roumeliotis","year":"2017","journal-title":"J Diabetes Complications"},{"issue":"01","key":"ref38","doi-asserted-by":"crossref","first-page":"6586","DOI":"10.1038\/s41598-020-63013-8","article-title":"Matrix Gla protein is an independent predictor of both intimal and medial vascular calcification in chronic kidney disease","volume":"10","author":"A MG Jaminon","year":"2020","journal-title":"Sci Rep"}],"container-title":["Thrombosis and 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