{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:00:44Z","timestamp":1770742844874,"version":"3.49.0"},"reference-count":6,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"Abstract<\/jats:title>\n This study aimed to describe the epidemiology, pathogens, and outcomes associated with early-onset and late-onset sepsis among newborns admitted to the leading public neonatal hospital in Mexico.<\/jats:p>\n We conducted a retrospective cohort study of infants admitted to the neonatal intensive care unit (NICU) at the Instituto Nacional de Perinatolog\u00eda in Mexico City from 2018 to 2023. Early-onset sepsis (EOS) was defined as a culture-confirmed bacterial infection of blood or cerebrospinal fluid within 3 days of birth, and late-onset sepsis (LOS) as culture-confirmed bacterial or fungal infection after day 3. Descriptive statistics and logistic regression were used to compare characteristics and outcomes among infants with and without EOS\/LOS.<\/jats:p>\n Among 4,381 admitted infants, 23 (0.5%) had EOS (5.2 per 1,000 admissions), and 444 of 3,950 (11.2%) who survived >3 days had LOS (112.4 per 1,000). Prematurity was a major risk factor. Escherichia coli accounted for 70% of EOS, and coagulase-negative staphylococci and Klebsiella spp. were the leading causes of LOS. Infections were associated with higher morbidity, longer hospitalization, and reduced survival, though mortality differences were not statistically significant after adjustment.<\/jats:p>\n Neonatal sepsis remains a major burden in this Mexican NICU, with a predominance of gram-negative organisms and incidence rates higher than recent U.S. reports. Continued surveillance and antimicrobial stewardship are warranted to guide empiric therapy and track resistance patterns.<\/jats:p>","DOI":"10.1055\/a-2601-8982","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T19:01:32Z","timestamp":1746644492000},"page":"422-424","source":"Crossref","is-referenced-by-count":2,"title":["Neonatal Sepsis Epidemiology at a Major Public Hospital in Mexico City"],"prefix":"10.1055","volume":"43","author":[{"given":"Hector","family":"Zavaleta","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Instituto Nacional de Perinatolog\u00eda, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guadalupe","family":"Cordero","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Instituto Nacional de Perinatolog\u00eda, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika M.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Vermont Oxford Network, Burlington, Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2883-4683","authenticated-orcid":false,"given":"Dustin D.","family":"Flannery","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/archdischild-2020-320217","article-title":"Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis","volume":"106","author":"C Fleischmann","year":"2021","journal-title":"Arch Dis Child"},{"issue":"80","key":"ref2","first-page":"99","article-title":"Agentes causales de sepsis neonatal temprana y tard\u00eda: una revisi\u00f3n de diez a\u00f1os en el \u201cHospital Infantil Privado\u201d","volume":"20","author":"P Saltigeral Simental","year":"2007","journal-title":"Rev Enf Infec Pediatr"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1542\/neo.23-10-e756","article-title":"Neonatal early-onset sepsis","volume":"23","author":"D D Flannery","year":"2022","journal-title":"Neoreviews"},{"issue":"03","key":"ref4","first-page":"317","article-title":"Sepsis neonatal temprana y factores asociados","volume":"55","author":"R Anaya-Prado","year":"2017","journal-title":"Rev Med Inst Mex Seguro Soc"},{"issue":"03","key":"ref5","first-page":"110","article-title":"Epidemiolog\u00eda de infecci\u00f3n neonatal temprana y tard\u00eda en una Unidad de Cuidados Intensivos Neonatales","volume":"86","author":"A Ulloa-Ric\u00e1rdez","year":"2019","journal-title":"Rev del Hosp Ju\u00e1rez M\u00e9xico"},{"issue":"02","key":"ref6","first-page":"90","article-title":"Morbilidad y mortalidad por sepsis neonatal en un hospital de tercer nivel de atenci\u00f3n","volume":"45","author":"M A Rodr\u00edguez-Weber","year":"2003","journal-title":"Salud Publica Mex"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2601-8982.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:13:35Z","timestamp":1770682415000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2601-8982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,7]]},"references-count":6,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,2,9]]},"published-print":{"date-parts":[[2026,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2601-8982","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5,7]]},"published":{"date-parts":[[2025,5,7]]}}}