{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:38:18Z","timestamp":1789799898102,"version":"4.0.1"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obesity, linked to various comorbidities like metabolic syndrome (MS) due to\n                        its proinflammatory nature, contributes to elevated exhaled nitric oxide\n                        levels, impacting multiple physiological systems, including the respiratory\n                        system. This study aimed to examine the impact of obesity and MS on lung\n                        function and airway inflammation in adolescents. We investigated the\n                        relationship between body fat distribution and pulmonary function\n                        parameters, and assess fractional exhaled nitric oxide (FeNO) levels as an\n                        indicator of airway inflammation.<\/jats:p><jats:p>This study included 100 children aged 10 to 18 years, comprising 50 obese\n                        individuals and 50 non-obese healthy controls. Participants were categorized\n                        based on their relative body mass index (RBMI), presence of MS, and body fat\n                        distribution. Pulmonary function tests and FeNO levels were compared between\n                        the groups.<\/jats:p><jats:p>The FEV1\/FVC and FRC values were significantly lower in the obese group.\n                        Among obese participants, MS was present in 30%, and those with MS had\n                        higher ERV. In male subjects, FEV1\/FVC was lower and FeNO levels were higher\n                        in those with increased waist circumference. There was a positive\n                        correlation between RBMI and FVC, TLC, and a negative correlation between\n                        RBMI and FEV1\/FVC, FRC. Negative correlations were also detected between\n                        waist and neck circumferences and FEV1\/FVC, FRC, RV values.<\/jats:p><jats:p>Obesity and MS negatively impact pulmonary function, particularly reducing\n                        FEV1\/FVC and FRC. Furthermore, central adiposity may contribute to airway\n                        inflammation, as indicated by increased FeNO levels.<\/jats:p>","DOI":"10.1055\/a-2602-5567","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:56:58Z","timestamp":1752231418000},"page":"235-242","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Obesity and Metabolic Syndrome on Pulmonary Functions and\n                    Exhaled Nitric Oxide in Adolescents"],"prefix":"10.1055","volume":"237","author":[{"given":"Nermin","family":"Hetemli","sequence":"additional","affiliation":[{"name":"Department of Child Health and Diseases, Ankara University Faculty of\n                    Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2146-9284","authenticated-orcid":false,"given":"Fazilcan","family":"Zirek","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology, Ankara University Faculty of Medicine, Ankara,\n                    Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukiye","family":"Uyan\u0131k","sequence":"additional","affiliation":[{"name":"paediatric endocrinology, Ankara University Faculty of Medicine,\n                    Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merih","family":"Berberoglu","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Ankara University Faculty of Medicine, Ankara,\n                    Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Siklar","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Ankara University Faculty of Medicine, Ankara,\n                    Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazan","family":"Cobanoglu","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology, Ankara University Faculty of Medicine, Ankara,\n                    Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/j.1399-5448.2007.00271.x","article-title":"The metabolic syndrome in children and adolescents \u2013 an IDF consensus\n                    report","volume":"8","author":"P Zimmet","year":"2007","journal-title":"Pediatr Diabetes"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1513\/AnnalsATS.201703-263WS","article-title":"An official american thoracic society workshop report: obesity and metabolism.\n                    An emerging frontier in lung health and disease","volume":"14","author":"B T Suratt","year":"2017","journal-title":"Ann Am Thorac Soc"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2004173","DOI":"10.1183\/13993003.04173-2020","article-title":"European Respiratory Society clinical 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Flashner","year":"2020","journal-title":"Pediatr Pulmonol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"24532","DOI":"10.1038\/srep24532","article-title":"Associations of exhaled carbon monoxide and fractional exhaled nitric oxide with\n                    metabolic syndrome: a cohort Study","volume":"6","author":"Y Guo","year":"2016","journal-title":"Sci Rep"}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2602-5567.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:57:09Z","timestamp":1752231429000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2602-5567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":22,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2025,7,10]]},"published-print":{"date-parts":[[2025,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2602-5567","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"value":"0300-8630","type":"print"},{"value":"1439-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}