{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:57:31Z","timestamp":1788908251160,"version":"build-2803163510"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to investigate the effect of aerobic exercise under hypoxic\n                    conditions (FiO2: 14.9%) on post-exercise hypotension compared to\n                    normoxic exercise matched for mechanical and physiological intensities. Twenty\n                    sedentary men completed three exercise sessions using a crossover design: (1)\n                    hypoxic exercise at 50% of peak power output, (2) normoxic exercise at 50% of\n                    peak power output (normoxic exercise matched for mechanical intensity), and (3)\n                    normoxic exercise with heart rates matched for hypoxic exercise. Expired gases\n                    and peripheral and muscle oxygen saturation were measured during the exercise.\n                    Blood pressure and hemodynamic variables were assessed before and after each\n                    exercise session. Hypoxic exercise and normoxic exercise matched for\n                    physiological intensity elicited higher heart rate, oxygen consumption, and\n                    ventilation compared to normoxic exercise matched for mechanical intensity\n                        (p&lt;0.05). Hypoxic exercise showed the lowest ventilation\n                    efficiency (p&lt;0.01) and the most severe systemic and muscle hypoxemia\n                        (p&lt;0.01) during exercise. Only hypoxic exercise induced\n                    significant post-exercise hypotension (\u22126.9 mmHg; p&lt;0.01) with a\n                    significant increase in common femoral artery diameter during recovery\n                    (p&lt;0.05). Our findings suggested that hypoxic exercise significantly\n                    enhances post-exercise vasodilation compared to normoxic exercise, resulting in\n                    greater post-exercise hypotension. This highlighted hypoxic exercise as a\n                    promising strategy for managing hypertension with reduced mechanical stress,\n                    particularly beneficial for individuals with low exercise tolerance.<\/jats:p>","DOI":"10.1055\/a-2602-9020","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T19:10:57Z","timestamp":1751915457000},"page":"817-826","source":"Crossref","is-referenced-by-count":1,"title":["Hypoxic exercise enhances post-exercise hypotension compared to\n                    normoxic exercise"],"prefix":"10.1055","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8217-9648","authenticated-orcid":false,"given":"Tae-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Graduate School, Kyung Hee\n                    University, Yongin, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Hyeok","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Graduate School, Kyung Hee\n                    University, Yongin, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Hee","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Graduate School, Kyung Hee\n                    University, Yongin, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3465-8965","authenticated-orcid":false,"given":"Hyun-Chul","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Graduate School, Kyung Hee\n                    University, Yongin, Korea (the Republic of)"},{"name":"Department of Sports Coaching, College of Physical Education, Kyung Hee\n                    University, Yongin, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Graduate School, Kyung Hee\n                    University, Yongin, Korea (the Republic of)"},{"name":"Department of Sports Medicine, College of Physical Education, Kyung Hee\n                    University, Yongin, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1111\/jch.13741","article-title":"S\u00e3o Paulo call to action for the prevention and control of high blood pressure:\n                    2020","volume":"21","author":"NR C Campbell","year":"2019","journal-title":"J Clin Hypertension"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1744-618X.2010.01146.x","article-title":"Prevalence of sedentary lifestyle in individuals with high blood pressure","volume":"21","author":"N G Guedes","year":"2010","journal-title":"Int J Nurs Terminol Classif"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1113\/expphysiol.2011.058065","article-title":"Postexercise hypotension and sustained postexercise vasodilatation: what happens\n                    after we exercise?","volume":"98","author":"J R Halliwill","year":"2013","journal-title":"Exp Physiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/JSM.0000000000000475","article-title":"Postexercise hypotension as a predictor for long-term training-induced blood\n                    pressure reduction: a large-scale randomized controlled trial","volume":"28","author":"M Wegmann","year":"2018","journal-title":"Clin J Sport Med"},{"key":"ref5","first-page":"54","article-title":"Postexercise hypotension and hemodynamics: the role of exercise intensity","volume":"44","author":"C L Forjaz","year":"2004","journal-title":"J Sports Med Phys Fit"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3389\/fphys.2017.00514","article-title":"Endurance Training in Normobaric Hypoxia Imposes Less Physical Stress for\n                    Geriatric Rehabilitation","volume":"8","author":"S Pramsohler","year":"2017","journal-title":"Front Physiol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1055\/a-1015-0647","article-title":"Cardiac Autonomic and Physiological Responses to Moderate- intensity Exercise in\n                    Hypoxia","volume":"40","author":"A Fornasiero","year":"2019","journal-title":"Int J Sports Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1007\/s00421-021-04678-5","article-title":"Post-exercise cardiac autonomic and cardiovascular responses to heart\n                    rate-matched and work rate-matched hypoxic exercise","volume":"121","author":"A Fornasiero","year":"2021","journal-title":"Eur J Appl Physiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00421-008-0868-6","article-title":"Short-term hypoxia reduces arterial stiffness in healthy men","volume":"105","author":"H Vedam","year":"2009","journal-title":"Eur J Appl Physiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10286-006-0395-7","article-title":"The autonomic nervous system at high altitude","volume":"17","author":"R Hainsworth","year":"2007","journal-title":"Clin Auton Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1152\/japplphysiol.00256.2015","article-title":"Skeletal muscle vasodilation during systemic hypoxia in humans","volume":"120","author":"F A Dinenno","year":"2016","journal-title":"J Appl Physiol 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and chronic effects of high-intensity exercise in hypoxia on blood\n                    pressure and post-exercise hypotension: A randomized cross-over trial","volume":"99","author":"G Kleinnibbelink","year":"2020","journal-title":"Med (Baltim)"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1097\/HJH.0000000000001479","article-title":"Systemic blood pressure at exercise in hypoxia in hypertensive and normotensive\n                    patients","volume":"35","author":"L Winkler","year":"2017","journal-title":"J Hypertens"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1456972","DOI":"10.1155\/2018\/1456972","article-title":"Impact of Resistance Exercise under Hypoxia on Postexercise Hemodynamics in\n                    Healthy Young Males","volume":"2018","author":"M Horiuchi","year":"2018","journal-title":"Int J Hypertens"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"546","DOI":"10.3389\/fphys.2019.00546","article-title":"Mild Hypobaric Hypoxia Enhances Post-exercise Vascular Responses in Young Male\n                    Runners","volume":"10","author":"Y Saito","year":"2019","journal-title":"Front Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1152\/japplphysiol.00701.2018","article-title":"Hypoxia-induced vagal withdrawal is independent of the hypoxic ventilatory\n                    response in men","volume":"126","author":"C Siebenmann","year":"2019","journal-title":"J Appl Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"R2036","DOI":"10.1152\/ajpregu.00442.2007","article-title":"Inspiratory muscle work in acute hypoxia influences locomotor muscle fatigue and\n                    exercise performance of healthy humans","volume":"293","author":"M Amann","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.resp.2005.12.015","article-title":"Consequences of exercise-induced respiratory muscle work","volume":"151","author":"J A Dempsey","year":"2006","journal-title":"Resp Physiol Neurobiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1152\/jappl.1998.85.2.609","article-title":"Effects of respiratory muscle work on cardiac output and its distribution during\n                    maximal exercise","volume":"85","author":"C A Harms","year":"1998","journal-title":"J Appl Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1113\/jphysiol.2009.180489","article-title":"Nitric oxide contributes to the augmented vasodilatation during hypoxic\n                    exercise","volume":"588","author":"D P Casey","year":"2010","journal-title":"J Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"H1595","DOI":"10.1152\/ajpheart.1989.256.6.H1595","article-title":"Hypoxia stimulates release of endothelium-derived relaxant factor","volume":"256","author":"U Pohl","year":"1989","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1126\/science.276.5321.2034","article-title":"Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen\n                    gradient","volume":"276","author":"J S Stamler","year":"1997","journal-title":"Science"},{"key":"ref26","volume-title":"Physiology, cardiovascular","author":"R Chaudhry","year":"2022"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00421-008-0735-5","article-title":"Influence of sildenafil on lung diffusion during exposure to acute hypoxia at\n                    rest and during exercise in healthy humans","volume":"103","author":"E M Snyder","year":"2008","journal-title":"Eur J Appl Physiol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3390\/biology11010144","article-title":"Metabolic, Cardiac, and Hemorheological Responses to Submaximal 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