{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T04:17:59Z","timestamp":1749010679549,"version":"3.41.0"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zentralbl Chir"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die simultane Pankreas-Nieren-Transplantation (SPN) ist die einzige etablierte Therapie zur Heilung des Diabetes mellitus Typ I mit diabetischer Nephropathie und pr\u00e4terminaler\/terminaler Niereninsuffizienz. Trotz eines hohen Bedarfs mit im Jahre 2022 551 gelisteten Patienten auf der Warteliste in Deutschland wurden nur etwa 42 Pankreastransplantationen in diesem Jahr durchgef\u00fchrt. Somit kommt es bei Wartezeiten zwischen 2 und 3 Jahren geh\u00e4uft zu Todesf\u00e4llen auf der Warteliste. Neben der SPN kommen die isolierte Pankreastransplantation (IPT) und die Pankreastransplantation nach Nierentransplantation (PTN) nur f\u00fcr spezielle Indikationen infrage. Strenge Selektionskriterien sind essenziell, da Patienten mit langj\u00e4hrigem Typ-I-Diabetes h\u00e4ufig kardiovaskul\u00e4re Komorbidit\u00e4ten aufweisen und somit \u00fcber ein erh\u00f6htes Risikoprofil f\u00fcr intra- und postoperative Komplikationen verf\u00fcgen. Die Spenderauswahl ist aufgrund limitierter Organzahlen und strenger Qualit\u00e4tsanforderungen herausfordernd. Eine verbesserte Ausbildung in hochspezialisierten Zentren k\u00f6nnte die chirurgische Expertise sichern. Trotz hoher perioperativer und postoperativer Komplikationsraten zeigt die SPN langfristig gute Ergebnisse mit einer durchschnittlichen Transplantatfunktion von \u00fcber 12 Jahren und sichert den Patienten somit ein verbessertes Langzeit\u00fcberleben. Die SPN bleibt der Goldstandard zur Heilung des Diabetes mellitus Typ I, bedarf aber struktureller Anpassungen zur Sicherstellung ihrer langfristigen Durchf\u00fchrung.<\/jats:p>","DOI":"10.1055\/a-2604-4396","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T23:24:33Z","timestamp":1748993073000},"page":"243-250","source":"Crossref","is-referenced-by-count":0,"title":["Pankreastransplantation"],"prefix":"10.1055","volume":"150","author":[{"given":"Richard-Ludwig","family":"Schumann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Chirurgie, Knappschaft Kliniken Universit\u00e4tsklinikum Bochum, Bochum, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas A.","family":"Schnitzbauer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Chirurgie, Knappschaft Kliniken Universit\u00e4tsklinikum Bochum, Bochum, 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