{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:34Z","timestamp":1752105634735,"version":"3.41.2"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study, involving a cohort of 980 patients with arterial and\/or venous events, evaluated the relative importance of genetic and traditional risk factors using a machine learning model approach. The analysis revealed that conventional risk factors\u2014such as age, gender, tobacco use, obesity\u2014and acquired thrombophilia (most prominently antiphospholipid syndrome [APS]) outperformed any genetic risk variants analyzed. Of note, the presence of heterozygous FVL mutations was associated with a reduced arterial risk, whereas carriers of heterozygous factor VII activation protease (FSAP) mutations had a lower risk of venous events.<\/jats:p><jats:p>Thus, by employing diverse statistical approaches, the study showed that acquired risk factors exert the most substantial impact on the development of thrombotic events, except for the well-known role of FVL mutations in venous events.<\/jats:p>","DOI":"10.1055\/a-2614-8526","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T12:41:16Z","timestamp":1752064876000},"source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Genetic and Acquired Risk Factors on Thromboembolic Events: A Retrospective Study"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5163-9807","authenticated-orcid":false,"given":"Luca","family":"Rapino","sequence":"additional","affiliation":[{"name":"Rheumatology, Department of Clinical Internal, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana-Luisa","family":"Stefanski","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany"},{"name":"Deutsches Rheumaforschungszentrum Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"D\u00f6rner","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany"},{"name":"Deutsches Rheumaforschungszentrum Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"749342","DOI":"10.3389\/fcvm.2021.749342","article-title":"Long-term survival after venous thromboembolism: a prospective cohort study","volume":"8","author":"H Nilius","year":"2021","journal-title":"Front Cardiovasc Med"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"e583","DOI":"10.1016\/S2352-3026(20)30211-8","article-title":"Mortality risk associated with venous thromboembolism: a systematic review and Bayesian meta-analysis","volume":"7","author":"N D Klemen","year":"2020","journal-title":"Lancet Haematol"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/CIRCRESAHA.115.306841","article-title":"Global burden of thrombosis: epidemiologic aspects","volume":"118","author":"A M Wendelboe","year":"2016","journal-title":"Circ Res"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/17474086.2019.1583555","article-title":"Thrombophilia, risk factors and prevention","volume":"12","author":"E Campello","year":"2019","journal-title":"Expert Rev Hematol"},{"issue":"02","key":"ref5","first-page":"120","article-title":"Risk factors for venous and arterial thrombosis","volume":"9","author":"E Previtali","year":"2011","journal-title":"Blood Transfus"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1365-2141.2007.06973.x","article-title":"Common risk factors for both arterial and venous thrombosis","volume":"140","author":"G DO Lowe","year":"2008","journal-title":"Br J Haematol"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.3390\/ijms24043169","article-title":"A comprehensive review of risk factors for venous thromboembolism: from epidemiology to pathophysiology","volume":"24","author":"D Pastori","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1055\/s-0038-1642667","article-title":"New molecular insights into the genetics of thrombophilia. 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