{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:06:41Z","timestamp":1760404001772,"version":"build-2065373602"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prostaglandin E1 (PGE1, alprostadil) is essential in managing ductus-dependent\n                    congenital heart defects (CHD) in neonates. Although its common adverse effects\n                    are well documented, dermatologic manifestations remain rare and\n                    underrecognized. We report a term male neonate with a prenatal diagnosis of\n                    complex critical CHD who required PGE1 infusion and subsequently developed an\n                    annular migratory rash on the third postnatal day. The rash resolved within\n                    minutes of PGE1 dose reduction but recurred upon dose escalation, strongly\n                    suggesting a causal link. Following surgical palliation and discontinuation of\n                    PGE1, the skin findings resolved completely and did not recur. This case\n                    underscores a rare but distinctive cutaneous reaction to PGE1 therapy and\n                    highlights the importance of early recognition to avoid unnecessary diagnostic\n                    testing and interruption of life-saving treatment.<\/jats:p>","DOI":"10.1055\/a-2615-1248","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T19:11:06Z","timestamp":1749237066000},"page":"373-375","source":"Crossref","is-referenced-by-count":1,"title":["Annular Migratory Rash In a Newborn Related to Prostaglandin E1\n                    Infusion: A Case Report"],"prefix":"10.1055","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5631-500X","authenticated-orcid":false,"given":"Buse","family":"\u00d6nen Ocak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology,\n                    Ministry of Health Ankara Bilkent City Hospital, \u00c7ankaya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Refika","family":"Sirma Dokuzboy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology,\n                    Ministry of Health Ankara Bilkent City Hospital, \u00c7ankaya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayriye G\u00f6zde","family":"Kanmaz Kutman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology,\n                    Ministry of Health Ankara Bilkent City Hospital, \u00c7ankaya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"volume-title":"Prostaglandin E1. 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Lewis","year":"1981","journal-title":"Circulation"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1515\/JPM.2004.069","article-title":"Prostaglandin E[1] treatment in patent ductus arteriosus dependent congenital\n                    heart defects","volume":"32","author":"G T\u00e1losi","year":"2004","journal-title":"J Perinat Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/j.1442-200X.2007.02380.x","article-title":"Side-effects of long-term prostaglandin E1 treatment in neonates","volume":"49","author":"G T\u00e1losi","year":"2007","journal-title":"Pediatr Int"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1017\/S1047951120003297","article-title":"Low-dose prostaglandin E1 is safe and effective for critical congenital heart\n                    disease: is it time to revisit the dosing guidelines?","volume":"31","author":"D Vari","year":"2021","journal-title":"Cardiol 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Perinatol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1525-1470.1995.tb00123.x","article-title":"Subcutaneous fat necrosis, hypercalcemia, and prostaglandin E","volume":"12","author":"H Sharata","year":"1995","journal-title":"Pediatr Dermatol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1046\/j.1525-1470.2000.01712.x","article-title":"Neonatal urticaria due to prostaglandin E1","volume":"17","author":"E L Carter","year":"2000","journal-title":"Pediatr Dermatol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1111\/j.0736-8046.2004.21511.x","article-title":"The harlequin color change and association with prostaglandin E1","volume":"21","author":"J Rao","year":"2004","journal-title":"Pediatr Dermatol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1111\/ped.14581","article-title":"Neonatal harlequin color change associated with prostaglandin E(1)\n                    administration","volume":"63","author":"K Tsuboi","year":"2021","journal-title":"Pediatr Int"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"88","DOI":"10.25259\/KPJ_62_2023","article-title":"Prostaglandin E1-induced urticaria with harlequin change in a neonate with\n                    transposition of great vessels: A case report","volume":"39","author":"N K Panigrahi","year":"2024","journal-title":"Karnataka Paediatr J"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jdcr.2016.08.001","article-title":"An unusual migratory polycyclic eruption after administration of prostaglandin E\n                    in a neonate","volume":"2","author":"G J Young","year":"2016","journal-title":"JAAD Case Rep"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.jdcr.2017.03.009","article-title":"Re: An unusual migratory polycyclic eruption after administration of\n                    prostaglandin E in a neonate","volume":"3","author":"L Wheless","year":"2017","journal-title":"JAAD Case Rep"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1111\/pde.15617","article-title":"Prostaglandin E-induced polycyclic cutaneous eruption with geometric\n                    features","volume":"41","author":"A Shah","year":"2024","journal-title":"Pediatr Dermatol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1111\/j.1365-2133.1971.tb02527.x","article-title":"Prostaglandin E1: effect on human cutaneous vasculature and skin histamine","volume":"84","author":"J Sondergaard","year":"1971","journal-title":"Br J Dermatol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.clindermatol.2023.07.009","article-title":"Annular skin lesions in infancy","volume":"41","author":"G Agnihotri","year":"2023","journal-title":"Clin 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