{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:02:03Z","timestamp":1771977723246,"version":"3.50.1"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"name":"Department of Regional Health Research, the University of Southern Denmark"},{"DOI":"10.13039\/501100024075","name":"Region of Southern Denmark","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100024075","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the hepatic manifestation of obesity. Studies in mice link fibrinogen variation to obesity and MASLD, but how naturally occurring fibrinogen variants associate with obesity and MASLD in humans is unknown.<\/jats:p>\n                  <jats:p>To investigate associations of fibrinogen variants (fibrinogen \u03b3', fibrinogen \u03b1E, and sialylated fibrinogen) with obesity, MASLD, and fibrosis severity and examine changes in variants 2 years after bariatric surgery.<\/jats:p>\n                  <jats:p>We included 195 individuals with a body mass index (BMI)\u2009&gt;\u200935\u2009kg\/m2. A subgroup of 93 individuals, who underwent bariatric surgery (n\u2009=\u200935) or served as nonsurgical control group (n\u2009=\u200958), were followed for 2 years. Hepatic tissue samples were scored for MASLD and fibrosis. Fibrinogen variants were measured using enzyme-linked immunosorbent assay.<\/jats:p>\n                  <jats:p>Absolute levels of fibrinogen variants tended to be higher in individuals with BMI\u2009&gt;\u200945\u2009kg\/m2 compared with BMI\u2009&lt;\u200940\u2009kg\/m2 (\u0394\u03b3': 70 [95% confidence interval: \u221219, 160] \u00b5g\/mL; \u0394\u03b1E: 0.85 [\u22120.36, 2.06] \u00b5g\/mL; \u0394sialylated: 0.09 [\u22120.05, 0.24] arbitrary units [AU]). Absolute and relative fibrinogen \u03b1E levels increased with MASLD (\u0394\u03b1E: 2.04 [0.74, 3.35] \u00b5g\/mL; \u0394\u03b1E ratio: 0.05 [0.02, 0.08] %) and fibrosis (\u0394\u03b1E: 1.79 [0.48, 3.11] \u00b5g\/mL; \u0394\u03b1E ratio: 0.05 [0.02, 0.07] %), whereas relative fibrinogen \u03b3' levels decreased with fibrosis (\u0394\u03b3' ratio: \u22122.52 [\u22124.70, \u22120.35] %). After bariatric surgery, sialylated fibrinogen levels were lower (\u0394sialylated: \u22120.22 [\u22120.32, \u22120.11] AU), but relative levels of the fibrinogen variants were higher (\u0394\u03b3': 1.7 [0.03, 3.30] %; \u0394\u03b1E: 0.03 [0.001, 0.06] %; \u0394sialylated: 0.02 [0.002, 0.04] AU\/g\/L) compared with the control group.<\/jats:p>\n                  <jats:p>Obesity, MASLD, and fibrosis alter fibrinogen variant profiles in plasma suggesting that fibrinogen variation plays a role in these inflammatory conditions.<\/jats:p>","DOI":"10.1055\/a-2615-4682","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T20:01:01Z","timestamp":1747684861000},"page":"247-259","source":"Crossref","is-referenced-by-count":3,"title":["Association of Fibrinogen Variants with Severity of Obesity and Metabolic Liver Disease: 2-Year Follow-up after Bariatric Surgery"],"prefix":"10.1055","volume":"126","clinical-trial-number":[{"clinical-trial-number":"nct03535142","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3047-9924","authenticated-orcid":false,"given":"Nadja B.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Unit for Thrombosis Research, Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark"},{"name":"Department of Regional Health Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna-Marie Bloch","family":"M\u00fcnster","sequence":"additional","affiliation":[{"name":"Unit for Thrombosis Research, Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark"},{"name":"Department of Regional Health Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette Munk","family":"Lauridsen","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Gastroenterology and Hepatology, Liver Research Group, University Hospital of Southern Denmark, Esbjerg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaseelan","family":"Palarasah","sequence":"additional","affiliation":[{"name":"Unit for Thrombosis Research, Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark"},{"name":"Department of Cancer and Inflammation Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte W.","family":"Wernberg","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Gastroenterology and Hepatology, Liver Research Group, University Hospital of Southern Denmark, Esbjerg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea Ladegaard","family":"Gr\u00f8nkj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Gastroenterology and Hepatology, Liver Research Group, University Hospital of Southern Denmark, Esbjerg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte G.","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Liver Research Group, University Hospital of Southern Denmark, Esbjerg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Jonasson","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Gastroenterology and Hepatology, Liver Research Group, University Hospital of Southern Denmark, Esbjerg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7749-334X","authenticated-orcid":false,"given":"Moniek P.M.","family":"de Maat","sequence":"additional","affiliation":[{"name":"Unit for Thrombosis Research, Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark"},{"name":"Department of Regional Health Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Hematology, Cardiovascular Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0912-2437","authenticated-orcid":false,"given":"Else-Marie","family":"Bladbjerg","sequence":"additional","affiliation":[{"name":"Unit for Thrombosis Research, Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark"},{"name":"Department of Regional Health Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11886-024-02025-6","article-title":"The global epidemic of metabolic fatty liver disease","volume":"26","author":"E CZ Lee","year":"2024","journal-title":"Curr Cardiol Rep"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Z M 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chains","volume":"61","author":"J Martinez","year":"1983","journal-title":"Blood"},{"issue":"01","key":"ref29","first-page":"93","article-title":"Role of perturbated hemostasis in MASLD and its correlation with adipokines","volume":"14","author":"S Pezzino","year":"2024","journal-title":"Life (Basel)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1749-6632.1983.tb23259.x","article-title":"The abnormal carbohydrate composition of the dysfibrinogenemia associated with liver disease","volume":"408","author":"J Martinez","year":"1983","journal-title":"Ann N Y Acad Sci"}],"container-title":["Thrombosis and 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