{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T14:48:45Z","timestamp":1764859725035,"version":"3.44.0"},"reference-count":91,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"name":"Umm Al-Qura University, Saudi Arabia","award":["25UQU4280478GSSR01R"],"award-info":[{"award-number":["25UQU4280478GSSR01R"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To assess the effectiveness of modified constraint-induced movement therapy (mCIMT) in improving upper limb function and grip strength in children with hemiplegic cerebral palsy (CP). A comprehensive search was conducted from inception to August 2024. Eligibility criteria were studies evaluating the effectiveness of mCIMT on upper limb function in children with hemiplegic CP aged over 2 years. The following data was extracted from each study: participant characteristics, intervention, outcome measures, follow-up, and key findings. The risk of bias and the quality of the evidence were evaluated using the PEDro scale and the grading of recommendations assessment development and evaluation (GRADE), respectively. A meta-analysis using a random-effect model was performed, and standardized mean difference (SMD) with a 95% confidence interval (CI) was estimated for upper limb function and grip strength. A total of 25 studies (1,115 children) were included. PEDro scale revealed 12 good-quality studies, 8 fair-quality studies, and 5 poor-quality studies. The currently available evidence showed a significant large effect of mCIMT in improving upper limb function (SMD: 1.14 [95% CI: 0.46\u20131.83]; p\u2009=\u20090.001; 12 studies; 454 children; very-low-quality evidence) and significant medium effect in improving grip strength (SMD: 0.63 [95% CI: 0.12\u20131.14]; p\u2009=\u20090.02; 3 studies; 92 children; low-quality evidence). mCIMT could improve upper limb function and grip strength in children with hemiplegic CP. However, due to the low and very low quality of evidence, further high-quality trials are needed to confirm these effects. PROSPERO registration number (CRD42023413525).<\/jats:p>","DOI":"10.1055\/a-2616-4893","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T20:06:13Z","timestamp":1747771573000},"page":"281-301","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Modified Constraint-Induced Movement Therapy on Upper Limb Function in Children with Hemiplegic Cerebral Palsy"],"prefix":"10.1055","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3632-9548","authenticated-orcid":false,"given":"Ehab Mohamed","family":"Abd El-Kafy","sequence":"additional","affiliation":[{"name":"Department of Medical Rehabilitation Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0569-5078","authenticated-orcid":false,"given":"Nahla Ahmad","family":"Almatrafi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1039-7550","authenticated-orcid":false,"given":"Mohamed Salaheldien","family":"Alayat","sequence":"additional","affiliation":[{"name":"Department of Medical Rehabilitation Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0541-5772","authenticated-orcid":false,"given":"Nawal Alami","family":"Tawhari","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Samtah General Hospital, Ministry of Health, Jazan, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2397-062X","authenticated-orcid":false,"given":"Najwa Fawzi","family":"Abuallam","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Abha Maternity and Children Hospital, Ministry of Health, Abha, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9352-4916","authenticated-orcid":false,"given":"Hayam Mahmoud","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Medical Rehabilitation Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"e0191724","DOI":"10.1371\/journal.pone.0191724","article-title":"Association between socioeconomic status and cerebral palsy","volume":"13","author":"S H Tseng","year":"2018","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-3-319-67858-0_3","volume-title":"Epidemiology of the Cerebral Palsies, in Cerebral Palsy: A Multidisciplinary Approach, C.P. Panteliadis, Editor","author":"E Blair","year":"2018"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/09638280500158422","article-title":"The epidemiology of cerebral palsy: incidence, impairments and risk factors","volume":"28","author":"E Odding","year":"2006","journal-title":"Disabil Rehabil"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"e1226","DOI":"10.1542\/peds.2005-2768","article-title":"Development of hand function and precision grip control in individuals with cerebral palsy: a 13-year follow-up study","volume":"118","author":"A C Eliasson","year":"2006","journal-title":"Pediatrics"},{"issue":"17","key":"ref5","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.3109\/09638288.2011.650314","article-title":"Tactile function in children with unilateral cerebral palsy compared to typically developing children","volume":"34","author":"M L Auld","year":"2012","journal-title":"Disabil Rehabil"},{"issue":"07","key":"ref6","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/dmcn.14488","article-title":"Health-related quality of life and upper-limb impairment in children with cerebral palsy: developing a mapping algorithm","volume":"62","author":"U Tonmukayakul","year":"2020","journal-title":"Dev Med Child Neurol"},{"issue":"09","key":"ref7","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1017\/S0012162206001551","article-title":"Activities of daily living in children with hemiplegic cerebral palsy: a cross-sectional evaluation using the assessment of motor and process skills","volume":"48","author":"B R Van Zelst","year":"2006","journal-title":"Dev Med Child Neurol"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1177\/0269215510367994","article-title":"A systematic review of arm activity measures for children with hemiplegic cerebral palsy","volume":"24","author":"K Klingels","year":"2010","journal-title":"Clin Rehabil"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1177\/08830738060210110401","article-title":"Intensive pediatric constraint-induced therapy for children with cerebral palsy: randomized, controlled, crossover trial","volume":"21","author":"S C Deluca","year":"2006","journal-title":"J Child Neurol"},{"issue":"09","key":"ref10","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1469-8749.2009.03588.x","article-title":"The relationship between unimanual capacity and bimanual performance in children with congenital hemiplegia","volume":"52","author":"L Sakzewski","year":"2010","journal-title":"Dev Med Child Neurol"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3109\/09638288.2011.585214","article-title":"Effect of treatment environment on modified constraint-induced movement therapy results in children with spastic hemiplegic cerebral palsy: a randomized controlled trial","volume":"34","author":"H R Rostami","year":"2012","journal-title":"Disabil Rehabil"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1901\/jeab.1994.61-281","article-title":"An operant approach to rehabilitation medicine: overcoming learned nonuse by shaping","volume":"61","author":"E Taub","year":"1994","journal-title":"J Exp Anal Behav"},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1037\/0090-5550.43.2.152","article-title":"Constraint-induced movement therapy: a new approach to treatment in physical rehabilitation","volume":"43","author":"J E Crago","year":"1998","journal-title":"Rehabil Psychol"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/13638490601151836","article-title":"Pediatric CI therapy for stroke-induced hemiparesis in young children","volume":"10","author":"E Taub","year":"2007","journal-title":"Dev 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Atkins","year":"2004","journal-title":"BMJ"},{"issue":"04","key":"ref35","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jclinepi.2010.07.015","article-title":"GRADE guidelines: 3. Rating the quality of evidence","volume":"64","author":"H Balshem","year":"2011","journal-title":"J Clin Epidemiol"},{"issue":"04","key":"ref36","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables","volume":"64","author":"G Guyatt","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"ref37","first-page":"8","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"J Cohen","year":"1988","edition":"2nd ed."},{"issue":"02","key":"ref38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1037\/1082-989X.11.2.193","article-title":"Assessing heterogeneity in meta-analysis: Q statistic or I2 index?","volume":"11","author":"T B Huedo-Medina","year":"2006","journal-title":"Psychol Methods"},{"issue":"07","key":"ref39","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/PHM.0b013e3182247076","article-title":"Multisite trial comparing the efficacy of constraint-induced movement therapy with that of bimanual intensive training in children with hemiplegic cerebral palsy: postintervention results","volume":"90","author":"P Facchin","year":"2011","journal-title":"Am J Phys Med Rehabil"},{"issue":"09","key":"ref40","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.braindev.2012.11.001","article-title":"Efficacy of modified constraint induced movement therapy in improving upper limb function in children with hemiplegic cerebral palsy: a randomized controlled trial","volume":"35","author":"A Choudhary","year":"2013","journal-title":"Brain Dev"},{"issue":"02","key":"ref41","first-page":"65","article-title":"Forced-use therapy for children with cerebral palsy in the community setting: a single-blinded randomized controlled pilot trial","volume":"5","author":"F Eugster-Buesch","year":"2012","journal-title":"J Pediatr Rehabil Med"},{"issue":"04","key":"ref42","first-page":"357","article-title":"Effects of modified constraint-induced movement therapy in virtual environment on upper-limb function in children with spastic hemiparetic cerebral palsy: a randomised controlled trial","volume":"31","author":"H R Rostami","year":"2012","journal-title":"NeuroRehabilitation"},{"issue":"10","key":"ref43","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1589\/jpts.24.1029","article-title":"Effects of modified constraint-induced movement therapy on hand dexterity, grip strength and activities of daily living of children with cerebral palsy: a randomized control trial","volume":"24","author":"J Yu","year":"2012","journal-title":"J Phys Ther Sci"},{"issue":"06","key":"ref44","first-page":"1063","article-title":"To study the effect of play therapy and child friendly constraint induced momement therapy to improve hand function in spastic hemiplegic cerebral palsy children: a comparative study","volume":"2","author":"A Nahar","year":"2015","journal-title":"International Journal of Physiotherapy"},{"issue":"07","key":"ref45","first-page":"856","article-title":"Effectiveness of constraint induced movement therapy and bimanual therapy in children with hemiplegic cerebral palsy","volume":"8","author":"M R Begum","year":"2019","journal-title":"Int J Sci Res"},{"issue":"09","key":"ref46","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.3390\/jcm9092992","article-title":"Unimanual intensive therapy with or without unaffected hand containment in children with hemiplegia. A randomized controlled pilot study","volume":"9","author":"R Palomo-Carri\u00f3n","year":"2020","journal-title":"J Clin Med"},{"issue":"01","key":"ref47","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/09593985.2021.1999355","article-title":"The efficacy of two models of intensive upper limb training on health-related quality of life in children with hemiplegic cerebral palsy mainstreamed in regular schools: a double-blinded, randomized controlled trial","volume":"39","author":"H Bingol","year":"2023","journal-title":"Physiother Theory Pract"},{"issue":"08","key":"ref48","doi-asserted-by":"crossref","first-page":"924","DOI":"10.4328\/ACAM.20505","article-title":"Modified constraint-induced movement therapy versus mirror therapy on affected hand functions in hemiparetic children","volume":"12","author":"M ES Fakharany","year":"2021","journal-title":"Annals of Clinical and Analytical Medicine"},{"issue":"17","key":"ref49","first-page":"5412","article-title":"Efficacy of different approaches on quality of upper extremity function, dexterity and grip strength in hemiplegic children: a randomized controlled study","volume":"25","author":"R A Mohamed","year":"2021","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"05","key":"ref50","doi-asserted-by":"crossref","first-page":"e2020033878","DOI":"10.1542\/peds.2020-033878","article-title":"Constraint-induced movement therapy for cerebral palsy: a randomized trial","volume":"148","author":"S L Ramey","year":"2021","journal-title":"Pediatrics"},{"issue":"24","key":"ref51","doi-asserted-by":"crossref","first-page":"7500","DOI":"10.1080\/09638288.2021.2002441","article-title":"The effect of modified constraint-induced movement therapy in children with hemiparetic cerebral palsy. Consecutive or intermittent days?","volume":"44","author":"S Tezcan","year":"2022","journal-title":"Disabil Rehabil"},{"issue":"02","key":"ref52","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.arcped.2021.11.017","article-title":"Comparing the effects of modified constraint-induced movement therapy and bimanual training in children with hemiplegic cerebral palsy mainstreamed in regular school: a randomized controlled study","volume":"29","author":"H Bing\u00f6l","year":"2022","journal-title":"Arch Pediatr"},{"issue":"07","key":"ref53","doi-asserted-by":"crossref","first-page":"48","DOI":"10.52403\/ijhsr.20220706","article-title":"A comparative study of play therapy and child friendly constraint induced movement therapy in cerebral palsy","volume":"12","author":"K Harini","year":"2022","journal-title":"Int J Health Sci Res"},{"issue":"01","key":"ref54","first-page":"888","article-title":"Effectiveness of modified constraint\u2013induced movement therapy compared to hand arm bimanual intensive therapy on quality of upper extremity function in hemiplegic cerebral palsy children \u2013 an experimental study","volume":"21","author":"J H Babu","year":"2023","journal-title":"Neuroquantology"},{"issue":"04","key":"ref55","doi-asserted-by":"crossref","first-page":"106","DOI":"10.52403\/ijhsr.20230414","article-title":"Effectiveness of constraint induced movement therapy versus bimanual training in children with unilateral cerebral palsy","volume":"13","author":"I Bhargavi","year":"2023","journal-title":"Int J Health Sci Res"},{"issue":"04","key":"ref56","doi-asserted-by":"crossref","first-page":"7704205030","DOI":"10.5014\/ajot.2023.050104","article-title":"Efficacy of constraint-induced movement therapy versus bimanual intensive training on motor and psychosocial outcomes in children with unilateral cerebral palsy: a randomized trial","volume":"77","author":"K J Liang","year":"2023","journal-title":"Am J Occup 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Res"},{"issue":"02","key":"ref60","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/dmcn.13216","article-title":"\u2018Remind-to-move\u2019 treatment versus constraint-induced movement therapy for children with hemiplegic cerebral palsy: a randomized controlled trial","volume":"59","author":"V A Dong","year":"2017","journal-title":"Dev Med Child Neurol"},{"issue":"02","key":"ref61","first-page":"32","article-title":"Effect of modified constraint induced movement therapy and hand arm bimanual intensive training on upper extremity skills and functional performance in children with spastic hemiplegic cerebral palsy","volume":"11","author":"A Bansal","year":"2021","journal-title":"Int J Health Sci Res"},{"issue":"05","key":"ref62","first-page":"2296","article-title":"Clinical and parental perceptions on functional improvement with constraint induced movement therapy vs bimanual therapy in hemiplegic cerebral palsy","volume":"30","author":"H Ashok","year":"2024","journal-title":"Educational Administration: Theory and Practice"},{"issue":"02","key":"ref63","first-page":"45","article-title":"Effectiveness of modified constraint-induced movement therapy compared to hand-arm bimanual intensive therapy on quality of upper extremity function in hemiplegic cerebral palsy children - an experimental study: effectiveness of modified CIMT compared to habit on quality of upper extremity function in hemiplegic cerebral palsy children","volume":"12","author":"T Jain","year":"2021","journal-title":"Natl J Integr Res Med"},{"issue":"05","key":"ref64","doi-asserted-by":"crossref","first-page":"609","DOI":"10.2522\/ptj.20130166","article-title":"Upper extremity strength measurement for children with cerebral palsy: a systematic review of available instruments","volume":"94","author":"K J Dekkers","year":"2014","journal-title":"Phys Ther"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fneur.2014.00048","article-title":"Hand functioning in children with cerebral palsy","volume":"5","author":"C Arnould","year":"2014","journal-title":"Front Neurol"},{"issue":"11","key":"ref66","doi-asserted-by":"crossref","first-page":"987","DOI":"10.2340\/16501977-0886","article-title":"Linking cerebral palsy upper limb measures to the International Classification of Functioning, Disability and Health","volume":"43","author":"B Hoare","year":"2011","journal-title":"J Rehabil Med"},{"issue":"01","key":"ref67","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1469-8749.2009.03369.x","article-title":"Upper limb activity measures for 5- to 16-year-old children with congenital hemiplegia: a systematic review","volume":"52","author":"R Gilmore","year":"2010","journal-title":"Dev Med Child Neurol"},{"issue":"02","key":"ref68","first-page":"CD004149","article-title":"Constraint-induced movement therapy in the treatment of the upper limb in children with hemiplegic cerebral palsy","volume":"2","author":"B J Hoare","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"volume-title":"International classification of functioning, disability and health: children and youth version: ICF-CY","year":"2007","first-page":"17","key":"ref69"},{"volume-title":"Evidence-Based Care Guideline for Pediatric Constraint Induced Movement Therapy","year":"2014","author":"K Harpster","key":"ref70"},{"issue":"01","key":"ref71","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/11038120310004529","article-title":"Development of the assisting hand assessment: a rasch-built measure intended for children with unilateral upper limb impairments","volume":"10","author":"L Krumlinde-Sundholm","year":"2003","journal-title":"Scand J Occup Ther"},{"issue":"10","key":"ref72","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1177\/0883073809341268","article-title":"Pediatric constraint-induced movement therapy is associated with increased contralateral cortical activity on functional magnetic resonance imaging","volume":"24","author":"T L Sutcliffe","year":"2009","journal-title":"J Child Neurol"},{"issue":"03","key":"ref73","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1055\/s-2007-985904","article-title":"Cortical neuromodulation by constraint-induced movement therapy in congenital hemiparesis: an FMRI study","volume":"38","author":"H Juenger","year":"2007","journal-title":"Neuropediatrics"},{"issue":"11","key":"ref74","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1177\/0883073815572686","article-title":"Resting state and diffusion neuroimaging predictors of clinical improvements following constraint-induced movement therapy in children with hemiplegic cerebral palsy","volume":"30","author":"K Y Manning","year":"2015","journal-title":"J Child 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