{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:27:40Z","timestamp":1786494460832,"version":"build-2736575974"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CDH fetuses may present with abnormal brain volume and cerebral fissures. Since cardiac function and size may also be altered, we hypothesized that abnormal cardiac function may contribute to the impaired brain development in these fetuses. The aim of this study is to evaluate whether cardiac dimensions and function correlate with brain development in CDH fetuses.<\/jats:p>\n                  <jats:p>All fetuses with left CDH who underwent ultrasound evaluation of cardiac function and brain development between 2018 and 2023 were included. We analyzed the correlation between cardiac size and function parameters with the parieto-occipital (POF) and Sylvian (SF) fissures and insular depth (ID) in 2 gestational periods (GP). Cardiac and brain anatomical measures were corrected for head circumference, and cardiac function parameters were corrected for estimated fetal weight or GA. Correlations were analyzed using the Pearson test. A p-value &lt;0.05 was considered significant.<\/jats:p>\n                  <jats:p>24 fetuses with left CDH were included. Between 20 and 24 weeks of gestation, POF, SF, and ID were significantly correlated with aortic flow. Right ventricle E\/A was significantly correlated with POF and SF, with a trend toward a correlation with ID, approaching the threshold of significance. In this GP, the ID was also significantly correlated with the left ventricle area, E\/A, and E\u2019, S\u2019 and A\u2019. Most correlations were lost in the next GP.<\/jats:p>\n                  <jats:p>Between 20 and 24 weeks of gestation, brain development in fetuses with CDH is significantly correlated with cardiac function. Most of these correlations were lost at 25\u201328 weeks of gestation. Further studies are needed to confirm our results and to evaluate whether these findings have postnatal clinical significance.<\/jats:p>","DOI":"10.1055\/a-2618-3187","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T19:37:32Z","timestamp":1747856252000},"page":"382-388","source":"Crossref","is-referenced-by-count":0,"title":["Strong heart, fit brain. Cardiac impact on brain development in fetuses with congenital diaphragmatic hernia: a prospective cohort study"],"prefix":"10.1055","volume":"47","author":[{"given":"Isabella","family":"Fabietti","sequence":"additional","affiliation":[{"name":"Bambino Gesu Pediatric Hospital IRCCS, Italy","place":["Roma"],"department":["Area of Fetal, Neonatal and Cardiological Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Vassallo","sequence":"additional","affiliation":[{"name":"Bambino Gesu Pediatric Hospital IRCCS, Italy","place":["Roma"],"department":["Area of Fetal, Neonatal and Cardiological Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Viggiano","sequence":"additional","affiliation":[{"name":"Bambino Gesu Pediatric Hospital IRCCS, Italy","place":["Roma"],"department":["Area of Fetal, Neonatal and Cardiological Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Claudia","family":"Massolo","sequence":"additional","affiliation":[{"name":"Bambino Gesu Pediatric Hospital IRCCS, Italy","place":["Roma"],"department":["Area of Fetal, Neonatal and Cardiological Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Valfr\u00e8","sequence":"additional","affiliation":[{"name":"Bambino Gesu Pediatric Hospital IRCCS, Italy","place":["Roma"],"department":["Area of Fetal, Neonatal and Cardiological Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Sala","sequence":"additional","affiliation":[{"name":"University of Udine, Friuli-Venezia Giulia, Italy","place":["Udine"],"department":["Department of Medicine (DMED)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Driul","sequence":"additional","affiliation":[{"name":"Santa Maria della Misericordia University Hospital, Friuli-Venezia Giulia, Italy","place":["Udine"],"department":["Department of Medicine (DMED)"]},{"name":"Ospedale Santa Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale, Italy","place":["Udine"],"department":["Department of Maternal and Child Health, Obstetrics and Gynecology Clinic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Bagolan","sequence":"additional","affiliation":[{"name":"Bambino Gesu Pediatric Hospital IRCCS, Italy","place":["Roma"],"department":["Area of Fetal, Neonatal and Cardiological Sciences"]},{"name":"University of Rome Tor Vergata, Lazio, Italy","place":["Roma"],"department":["Department of Systems Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Caforio","sequence":"additional","affiliation":[{"name":"Bambino Gesu Pediatric Hospital IRCCS, Italy","place":["Roma"],"department":["Area of Fetal, Neonatal and Cardiological Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Morini","sequence":"additional","affiliation":[{"name":"University of Rome La Sapienza, Lazio, Italy","place":["Rome"],"department":["Department of Maternal, Child Health and Urological Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3174\/ajnr.A7760","article-title":"Longitudinal MRI Evaluation of Brain Development in Fetuses with Congenital Diaphragmatic Hernia around the Time of Fetal Endotracheal Occlusion AJNR Am","volume":"44","author":"D Emam","year":"2023","journal-title":"J Neuroradiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1111\/jon.13096","article-title":"Brain growth in fetuses with congenital diaphragmatic hernia","volume":"33","author":"F 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