{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T22:22:53Z","timestamp":1786659773841,"version":"build-2736575974"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It has been long suggested that the placenta \u201ceducates\u201d maternal platelets to contribute to a healthy pregnancy. Several studies have also demonstrated unique changes in platelet function and ultrastructure during pregnancy, some of which may drive hypertensive complications of pregnancy. One of the few proteins that are differentially found in the plasma of pregnant females when compared with non-pregnant females and males are the members of the pregnancy-specific glycoprotein (PSG) family, and PSG1 is one of the highest expressed and best characterized of all human PSGs. Because PSGs are secreted into the maternal circulation (by the trophoblast cells of the placenta), platelets may be picking up placental exosomes containing PSGs. Also, platelets may directly incorporate circulating PSGs, which are found in high concentration, as has been shown for other serum proteins, including fibrinogen. In this image report, we have utilized a state-of-the-art high-resolution imaging approach to examine the interactions of labeled recombinant PSG1 with non-permeabilized human platelets. Strikingly, we observed that human platelets internalize PSG1 and express PSGs during pregnancy.<\/jats:p>","DOI":"10.1055\/a-2618-4817","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T20:07:54Z","timestamp":1749586074000},"page":"332-334","source":"Crossref","is-referenced-by-count":1,"title":["Human Platelets Internalize Pregnancy-Specific Glycoprotein-1 (PSG1)"],"prefix":"10.1055","volume":"126","author":[{"given":"Ejaife O.","family":"Agbani","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Alberta, Canada"},{"name":"McCaig Institute for Bone and Joint Health, University of Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Perioperative and Pain Medicine, Cumming School of Medicine, University of Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Nicholas","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Perioperative and Pain Medicine, Cumming School of Medicine, University of Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibukun","family":"Akinrinade","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cumming School of Medicine, University of Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Slater","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Alberta, Canada"},{"name":"Department of Obstetrics and Gynecology, Cumming School of Medicine, University of Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Davizon-Castillo","sequence":"additional","affiliation":[{"name":"Bloodworks Research Institute, Seattle, Washington, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Dveksler","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.jtha.2023.03.014","article-title":"Overexpression of facilitative glucose transporter-3 and membrane procoagulation in maternal platelets of preeclamptic pregnancy","volume":"21","author":"E O Agbani","year":"2023","journal-title":"J Thromb Haemost"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.placenta.2021.12.009","article-title":"Maternal platelets at the first trimester maternal-placental interface\u2014small players with great impact on placenta development","volume":"125","author":"J Guettler","year":"2022","journal-title":"Placenta"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.3390\/cells11081256","article-title":"Proteomics and metabolomics profiling of platelets and plasma mediators of thrombo-inflammation in gestational hypertension and preeclampsia","volume":"11","author":"L GN de Almeida","year":"2022","journal-title":"Cells"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1387\/ijdb.130329gd","article-title":"Pregnancy-specific glycoproteins: complex gene families regulating maternal-fetal interactions","volume":"58","author":"T Moore","year":"2014","journal-title":"Int J Dev Biol"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/molehr\/gay044","article-title":"Activation of latent transforming growth factor-\u03b21, a conserved function for pregnancy-specific beta 1-glycoproteins","volume":"24","author":"J Warren","year":"2018","journal-title":"Mol Hum Reprod"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"e1800162","DOI":"10.1002\/prca.201800162","article-title":"The platelet releasate is altered in human pregnancy","volume":"13","author":"P B Szklanna","year":"2019","journal-title":"Proteomics Clin Appl"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"e57491","DOI":"10.1371\/journal.pone.0057491","article-title":"Pregnancy-specific glycoproteins bind integrin \u03b1IIb\u03b23 and inhibit the platelet-fibrinogen interaction","volume":"8","author":"D K Shanley","year":"2013","journal-title":"PLoS One"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1530\/REP-21-0390","article-title":"Pregnancy-specific glycoproteins: evolution, expression, functions and disease associations","volume":"163","author":"T Moore","year":"2022","journal-title":"Reproduction"},{"issue":"07","key":"ref9","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1074\/jbc.M114.597518","article-title":"Induction and activation of latent transforming growth factor-\u03b21 are carried out by two distinct domains of pregnancy-specific glycoprotein 1 (PSG1)","volume":"290","author":"A Ballesteros","year":"2015","journal-title":"J Biol Chem"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3390\/cells8111369","article-title":"Interaction of pregnancy-specific glycoprotein 1 with integrin \u03915\u03b21 is a modulator of extravillous trophoblast functions","volume":"8","author":"S Rattila","year":"2019","journal-title":"Cells"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2618-4817.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T23:32:21Z","timestamp":1771975941000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2618-4817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":10,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,2,24]]},"published-print":{"date-parts":[[2026,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2618-4817","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]}}}