{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T04:11:52Z","timestamp":1767931912943,"version":"3.49.0"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The authors report on a 21-year-old clinically asymptomatic female patient, who was admitted with two supratentorial intradural lesions in her follow-up magnetic resonance imaging 17 years after treatment of a posterior fossa medulloblastoma. Sequential surgical removal was performed. The left parietal tumor with dural involvement was diagnosed as a transitional meningioma WHO (World Health Organization) grade 1. The right temporal lesion, which had also close relationship to the dura, was diagnosed as a spindle cell sarcoma. We therefore report a metachronous tumor development of a benign and a malignant intradural sarcomatous tumor as secondary neoplasms following childhood medulloblastoma treatment.<\/jats:p>","DOI":"10.1055\/a-2618-6807","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T19:37:06Z","timestamp":1747942626000},"page":"063-068","source":"Crossref","is-referenced-by-count":0,"title":["Meningioma and Cerebral Spindle Cell Sarcoma as Two Different Metachronous Tumor Entities Secondary to Medulloblastoma Treatment in Childhood: Case Report and Review of the Literature"],"prefix":"10.1055","volume":"87","author":[{"given":"Anna","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, HELIOS Klinikum Erfurt, Erfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Brodhun","sequence":"additional","affiliation":[{"name":"Department of Pathology and Neuropathology, HELIOS Klinikum Erfurt, Erfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Lemmer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine 3, HELIOS Klinikum Erfurt, Erfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Gerlach","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, HELIOS Klinikum Erfurt, Erfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.14791\/btrt.2022.0046","article-title":"Medulloblastoma: current perspectives and recent advances","volume":"11","author":"J Y Choi","year":"2023","journal-title":"Brain Tumor Res Treat"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1177\/0883073815600866","article-title":"Medulloblastoma","volume":"31","author":"N E Millard","year":"2016","journal-title":"J Child Neurol"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-022-02522-4","article-title":"Identification of low and very high-risk patients with non-WNT\/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts","volume":"145","author":"M Mynarek","year":"2023","journal-title":"Acta Neuropathol"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s007010200025","article-title":"Supratentorial leptomeningeal metastasis of a medulloblastoma without cerebellar tumor recurrence","volume":"144","author":"R Gerlach","year":"2002","journal-title":"Acta Neurochir (Wien)"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF01410612","article-title":"Secondary manifestation of medulloblastoma: metastases and local recurrences in 66 patients","volume":"136","author":"U Sure","year":"1995","journal-title":"Acta Neurochir (Wien)"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.adro.2020.09.018","article-title":"Evaluation of prognostic factors and role of participation in a randomized trial or a prospective registry in pediatric and adolescent nonmetastatic medulloblastoma - a report from the HIT 2000 trial","volume":"5","author":"S Dietzsch","year":"2020","journal-title":"Adv Radiat Oncol"},{"issue":"06","key":"ref7","first-page":"865","article-title":"Second cancers after medulloblastoma: population-based results from the United States and Sweden","volume":"8","author":"A M Goldstein","year":"1997","journal-title":"Cancer Causes Control"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.ejca.2012.10.006","article-title":"Treatment of adult nonmetastatic medulloblastoma patients according to the paediatric HIT 2000 protocol: a prospective observational multicentre study","volume":"49","author":"C Friedrich","year":"2013","journal-title":"Eur J Cancer"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/ana.410240405","article-title":"Efficacy of adjuvant chemotherapy for patients with poor-risk medulloblastoma: a preliminary report","volume":"24","author":"R J Packer","year":"1988","journal-title":"Ann Neurol"},{"issue":"25","key":"ref10","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1200\/JCO.2006.06.4980","article-title":"Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma","volume":"24","author":"R J Packer","year":"2006","journal-title":"J Clin Oncol"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S1470-2045(06)70867-1","article-title":"Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial","volume":"7","author":"A Gajjar","year":"2006","journal-title":"Lancet Oncol"},{"issue":"21","key":"ref12","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1200\/JCO.2011.40.2792","article-title":"Outcome of children with metastatic medulloblastoma treated with carboplatin during craniospinal radiotherapy: a Children's Oncology Group Phase I\/II study","volume":"30","author":"R I Jakacki","year":"2012","journal-title":"J Clin Oncol"},{"issue":"08","key":"ref13","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1470-2045(05)70252-7","article-title":"Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children","volume":"6","author":"J Grill","year":"2005","journal-title":"Lancet Oncol"},{"key":"ref14","first-page":"5","article-title":"Impact of site of tumor recurrence upon survival for children with recurrent or progressive medulloblastoma","volume":"107","author":"D C Bowers","year":"2007","journal-title":"J Neurosurg"},{"issue":"09","key":"ref15","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00381-006-0062-2","article-title":"Metachronous secondary atypical meningioma and anaplastic astrocytoma after postoperative craniospinal irradiation for medulloblastoma","volume":"22","author":"A J Hope","year":"2006","journal-title":"Childs Nerv Syst"},{"issue":"03","key":"ref16","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/1097-0142(19840201)53:3<426::AID-CNCR2820530310>3.0.CO;2-L","article-title":"Radiation-induced intracranial neoplasms. A report of three possible cases","volume":"53","author":"J R Anderson","year":"1984","journal-title":"Cancer"},{"issue":"16","key":"ref17","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJM198810203191601","article-title":"Tumors of the brain and nervous system after radiotherapy in childhood","volume":"319","author":"E Ron","year":"1988","journal-title":"N Engl J Med"},{"issue":"04","key":"ref18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/ana.410040406","article-title":"Fatal long-term sequela following radiation \u201ccure\u201d for ependymoma","volume":"4","author":"D S Bachman","year":"1978","journal-title":"Ann Neurol"},{"issue":"01","key":"ref19","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3171\/jns.1995.83.1.0154","article-title":"Radiation-induced gliosarcoma. Case report and review of the literature","volume":"83","author":"B Kaschten","year":"1995","journal-title":"J Neurosurg"},{"issue":"04","key":"ref20","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1227\/00006123-199504000-00007","article-title":"Sarcomas subsequent to cranial irradiation","volume":"36","author":"S M Chang","year":"1995","journal-title":"Neurosurgery"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/B978-0-12-804280-9.00018-4","article-title":"Radiation-induced meningiomas","volume":"169","author":"C Benjamin","year":"2020","journal-title":"Handb Clin Neurol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.wneu.2016.09.094","article-title":"Radiation-induced meningiomas: an exhaustive review of the literature","volume":"97","author":"R Yamanaka","year":"2017","journal-title":"World Neurosurg"},{"issue":"05","key":"ref23","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/00000421-198910000-00010","article-title":"Radiation-associated sarcoma: a review of 23 patients with postradiation sarcoma over a 50-year period","volume":"12","author":"B E Amendola","year":"1989","journal-title":"Am J Clin Oncol"},{"issue":"07","key":"ref24","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/1097-0142(19870401)59:7<1274::AID-CNCR2820590708>3.0.CO;2-H","article-title":"Radiation-induced neoplasms of the brain","volume":"59","author":"P P Kumar","year":"1987","journal-title":"Cancer"},{"issue":"01","key":"ref25","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/1097-0142(197901)43:1<182::AID-CNCR2820430127>3.0.CO;2-S","article-title":"Postirradiation sarcoma of bone: a perspective","volume":"43","author":"A A Tountas","year":"1979","journal-title":"Cancer"},{"issue":"05","key":"ref26","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.ijrobp.2018.04.032","article-title":"Irradiation-induced secondary tumors following pediatric central nervous system tumors: experiences of a single institute in Taiwan (1975-2013)","volume":"101","author":"C Y Lee","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"S226","DOI":"10.1016\/j.bjorl.2022.01.003","article-title":"Secondary Ewing's sarcoma of the temporo-occipital region developed 12-years after medulloblastoma treatment","volume":"88","author":"Z Dudvarski","year":"2022","journal-title":"Braz J Otorhinolaryngol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/11795476221131189","article-title":"Primary intracranial spindle cell sarcoma, DICER1-mutant, with MDM2 amplification diagnosed on the basis of extensive molecular profiling","volume":"15","author":"T Nejo","year":"2022","journal-title":"Clin Med Insights Case Rep"},{"issue":"03","key":"ref29","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3171\/2015.6.PEDS14709","article-title":"Successful treatment of primary intracranial sarcoma with the ICE chemotherapy regimen and focal radiation in children","volume":"17","author":"L Lafay-Cousin","year":"2016","journal-title":"J Neurosurg Pediatr"}],"container-title":["Journal of Neurological Surgery Part A: Central European Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2618-6807.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:41:39Z","timestamp":1767915699000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2618-6807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":29,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2026,1,8]]},"published-print":{"date-parts":[[2026,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2618-6807","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6315","2193-6323"],"issn-type":[{"value":"2193-6315","type":"print"},{"value":"2193-6323","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5,22]]},"published":{"date-parts":[[2025,5,22]]}}}