{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T23:11:52Z","timestamp":1778022712940,"version":"3.51.4"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Surgery and stereotactic radiotherapy (SRT) are widely used for treating vestibular schwannomas (VS), but the impact of different SRT regimens remains debated. This study assesses outcomes of various SRT techniques in a large cohort.<\/jats:p>\n                  <jats:p>Retrospective cohort of consecutive patients treated in a large academic hospital between 2008 and 2024. All patients were treated with LINAC-based SRT. The study compared outcomes between single-dose SRS (12\u201315 Gy), five-fraction SRS (total of 25 Gy), and conventionally fractionated SRT (50.4\u2009Gy in 28 fractions). The main outcome was progression-free survival (PFS).<\/jats:p>\n                  <jats:p>The cohort included 197 patients, with a median age of 50.2 years, 65.5% of whom were female. The mean lesion size was 2.4\u2009cm, and 61.4% of lesions were classified as high-class Koos (III and IV). Median follow-up was 54.0 months (6\u2013142.1). Overall lesion control was 89.8% by RECIST 1.1 criteria, with no significant difference in PFS between the groups after propensity score matching. New hearing loss occurred in 14.7% of patients, whereas new facial palsy was reported in 3.0%. The presence of type-2 neurofibromatosis (NF2) was associated with poorer PFS (50.4 vs. 46.6 months, p\u2009=\u20090.002). Propensity score matching analysis was done and all regimens had similar PFS (matched sample size was 193, p\u2009=\u20090.808).<\/jats:p>\n                  <jats:p>Different SRT regimens showed similar outcomes for lesion control and toxicity in VS patients, including those with NF2. This study supports LINAC-based SRT as a flexible treatment option, although further prospective studies are needed.<\/jats:p>","DOI":"10.1055\/a-2620-0288","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T20:04:51Z","timestamp":1749585891000},"page":"256-263","source":"Crossref","is-referenced-by-count":0,"title":["Radiotherapy for Vestibular Schwannoma: Retrospective Cohort and Propensity Score Matching Analysis"],"prefix":"10.1055","volume":"87","author":[{"given":"Vinicius de Carvalho","family":"Gico","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo, Medical School of Sao Paulo University, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2050-3110","authenticated-orcid":false,"given":"Geovanne Pedro","family":"Mauro","sequence":"additional","affiliation":[{"name":"Department of Radiology and Oncology\u2014Discipline of Radiotherapy, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila Maria","family":"Da Roz","sequence":"additional","affiliation":[{"name":"Department of Neurology\u2014Discipline of Neurosurgery, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Weltman","sequence":"additional","affiliation":[{"name":"Department of Radiology and Oncology\u2014Discipline of Radiotherapy, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil"},{"name":"Department of Radiation Oncology, Hospital Israelita Albert Einstein, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evandro C\u00e9sar","family":"De Souza","sequence":"additional","affiliation":[{"name":"Department of Neurology\u2014Discipline of Neurosurgery, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosangela Correa","family":"Villar","sequence":"additional","affiliation":[{"name":"Department of Radiology and Oncology\u2014Discipline of Radiotherapy, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberval Gadelha","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Neurology\u2014Discipline of Neurosurgery, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Gilberto","family":"Carlotti","sequence":"additional","affiliation":[{"name":"Department of Neurology\u2014Discipline of Neurosurgery, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"issue":"01","key":"ref1","first-page":"23","article-title":"Improving outcomes in patients with vestibular schwannomas: microsurgery versus radiosurgery","volume":"57","author":"J M Sarmiento","year":"2013","journal-title":"J Neurosurg Sci"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.3390\/jcm13061611","article-title":"The recent management of vestibular schwannoma radiotherapy: a narrative review of the literature","volume":"13","author":"L Brun","year":"2024","journal-title":"J Clin Med"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s13643-022-02118-9","article-title":"Single-fraction stereotactic radiosurgery versus microsurgical resection for the treatment of vestibular schwannoma: a systematic review and meta-analysis","volume":"11","author":"T Jakubeit","year":"2022","journal-title":"Syst Rev"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"103337","DOI":"10.1016\/j.amjoto.2021.103337","article-title":"Treatment for vestibular schwannoma: systematic review and single arm meta-analysis","volume":"43","author":"N LB Thai","year":"2022","journal-title":"Am J Otolaryngol"},{"issue":"01","key":"ref5","first-page":"5","article-title":"Stereotactic radiosurgery for vestibular schwannoma: International Stereotactic Radiosurgery Society (ISRS) practice guideline","volume":"5","author":"M N Tsao","year":"2017","journal-title":"J Radiosurg SBRT"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/neuonc\/noz153","article-title":"EANO guideline on the diagnosis and treatment of vestibular schwannoma","volume":"22","author":"R Goldbrunner","year":"2020","journal-title":"Neuro-oncol"},{"issue":"01","key":"ref7","first-page":"97","article-title":"Radiation therapy (IMRT)","volume":"10","author":"R Prescribing","year":"2010","journal-title":"J ICRU"},{"key":"ref8","volume-title":"Morphological changes of vestibular schwannomas after radiosurgical treatment: pitfalls and diagnosis of failure","author":"C Delsanti","year":"2008"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/COC.0000000000001065","article-title":"Stereotactic radiosurgery for vestibular schwannoma with radiographic brainstem compression","volume":"47","author":"A N De Leo","year":"2024","journal-title":"Am J Clin Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e1192","DOI":"10.1016\/j.wneu.2018.03.175","article-title":"Place of gamma knife stereotactic radiosurgery in grade 4 vestibular schwannoma based on case series of 86 patients with long-term follow-up","volume":"114","author":"M Lefranc","year":"2018","journal-title":"World 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outcomes for large vestibular schwannomas in the upfront or post-surgical setting: a systematic review and International Stereotactic Radiosurgery Society (ISRS) Practice Guidelines","volume":"165","author":"C Tuleasca","year":"2023","journal-title":"J Neurooncol"},{"issue":"02","key":"ref34","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3171\/2022.4.JNS22203","article-title":"Stereotactic radiosurgery for Koos grade IV vestibular schwannoma: a multi-institutional study","volume":"138","author":"S Pikis","year":"2022","journal-title":"J Neurosurg"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e742","DOI":"10.1016\/j.wneu.2023.12.029","article-title":"Comparison of stereotactic radiosurgery and hypofractionated radiosurgery for vestibular schwannomas: a meta-analysis of available literature","volume":"182","author":"M Sharma","year":"2024","journal-title":"World Neurosurg"},{"issue":"04","key":"ref36","first-page":"391","article-title":"Efficacy and 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