{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:55:32Z","timestamp":1767920132482,"version":"3.49.0"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Perisplenic masses or collections are rare findings on imaging examinations. The differential diagnostic spectrum is broad. We report the case of an 84-year-old man who presented to our emergency department with fatigue, unwanted weight loss, loss of appetite and abdominal pain. In B-mode ultrasound a very hypoechoic collection circularly located around the spleen was seen. A splenic hematoma or an abscess were primarily suspected. Performing contrast-enhanced ultrasound examination the perisplenic collection was surprisingly strongly contrasted in the arterial phase. An additional abdominal CT confirmed the mass in the left upper abdomen circularly around the spleen, compressing the left colic flexure and beginning to infiltrate the gastric fundus. An ultrasound-guided tissue biopsy was taken via a percutaneous intercostal approach, which resulted in the diagnosis of a low-grade epithelioid malignant peritoneal mesothelioma (MPM). MPM often presents with diffuse multifocal involvement of the peritoneal lining, however a unifocal manifestation of MPM is uncommon in general. A perisplenic mass manifestation of malignant peritoneal mesothelioma is an extremely rare occurrence. This case highlights the diagnostic challenges posed by the rare perisplenic manifestation of MPM.<\/jats:p>","DOI":"10.1055\/a-2622-2136","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T18:58:01Z","timestamp":1750791481000},"page":"851-856","source":"Crossref","is-referenced-by-count":1,"title":["Perisplenic mass as initial diagnosis of malignant peritoneal mesothelioma"],"prefix":"10.1055","volume":"63","author":[{"given":"Christoph","family":"Petrynowski","sequence":"additional","affiliation":[{"name":"Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albrecht","family":"Neesse","sequence":"additional","affiliation":[{"name":"Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Ellenrieder","sequence":"additional","affiliation":[{"name":"Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Str\u00f6bel","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Amanzada","sequence":"additional","affiliation":[{"name":"Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8318-0315","authenticated-orcid":false,"given":"Golo","family":"Petzold","sequence":"additional","affiliation":[{"name":"Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s00261-020-02736-8","article-title":"A review of anatomy, pathology, and disease spread in the perisplenic region","volume":"46","author":"A Etchison","year":"2021","journal-title":"Abdom Radiol (NY)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1259\/bjr\/22454963","article-title":"An unusual perisplenic mass","volume":"83","author":"ITP Wells","year":"2010","journal-title":"Br J Radiol"},{"key":"ref3","first-page":"380","article-title":"Primary perisplenic hydatid cyst","volume":"19","author":"MA Sharif","year":"2009","journal-title":"J Coll Physicians Surg Pak"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.ejrad.2007.06.036","article-title":"The forgotten organ: contrast enhanced sonography of the spleen","volume":"64","author":"C G\u00f6rg","year":"2007","journal-title":"Eur J Radiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1093\/oxfordjournals.aje.a009093","article-title":"Analysis of current trends in United States mesothelioma incidence","volume":"145","author":"B Price","year":"1997","journal-title":"Am J Epidemiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3390\/cancers15010229","article-title":"Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States","volume":"15","author":"L Calthorpe","year":"2022","journal-title":"Cancers (Basel)"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"537","DOI":"10.21037\/tlcr.2018.10.04","article-title":"Malignant peritoneal mesothelioma: a review","volume":"7","author":"G Broeckx","year":"2018","journal-title":"Transl Lung Cancer Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"915","DOI":"10.21037\/jgo.2017.08.01","article-title":"Clinical presentation, diagnosis, classification and management of peritoneal mesothelioma: a review","volume":"8","author":"A Garc\u00eda-Fadrique","year":"2017","journal-title":"J Gastrointest Oncol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2022.115085","article-title":"Industry, occupation, and exposure history of mesothelioma patients in the U.S. National Mesothelioma Virtual Bank, 2006\u20132022","volume":"230","author":"Y Gao","year":"2023","journal-title":"Environ Res"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1093\/carcin\/bgt166","article-title":"Molecular pathogenesis of malignant mesothelioma","volume":"34","author":"Y Sekido","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.tranon.2018.01.005","article-title":"Mutational Profiling of Malignant Mesothelioma Revealed Potential Therapeutic Targets in EGFR and NRAS","volume":"11","author":"JE Kim","year":"2018","journal-title":"Transl Oncol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1177\/030089160308900307","article-title":"Clinical presentation of peritoneal mesothelioma","volume":"89","author":"YIZ Acherman","year":"2003","journal-title":"Tumori"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1097\/PAS.0000000000001545","article-title":"Malignant Mesothelioma of the Peritoneum in Women: A Clinicopathologic Study of 164 Cases","volume":"45","author":"A Malpica","year":"2021","journal-title":"Am J Surg Pathol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.21037\/jgo-24-266","article-title":"The rare occurrence of unifocal peritoneal mesothelioma: a case report, literature review, and future directions","volume":"15","author":"S Ghabra","year":"2024","journal-title":"J Gastrointest Oncol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jasc.2021.08.007","article-title":"Peritoneal malignant mesothelioma: Slippery like an eel to diagnose on cytology-case series of 3 cases","volume":"11","author":"N Gupta","year":"2022","journal-title":"J Am Soc Cytopathol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"316","DOI":"10.4329\/wjr.v12.i12.316","article-title":"Unusual radiologic presentations of malignant peritoneal mesothelioma","volume":"12","author":"PH Sugarbaker","year":"2020","journal-title":"World J Radiol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/emp2.13123","article-title":"Contrast-enhanced point of care ultrasound for the evaluation of stable blunt abdominal trauma by the emergency physician: A prospective diagnostic study","volume":"5","author":"V Donner","year":"2024","journal-title":"J Am Coll Emerg Physicians Open"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s11547-023-01679-6","article-title":"New microvascular ultrasound techniques: abdominal applications","volume":"128","author":"R Cannella","year":"2023","journal-title":"Radiol Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s12199-007-0017-6","article-title":"Pathology of mesothelioma","volume":"13","author":"K Inai","year":"2008","journal-title":"Environ Health Prev Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1097\/PAS.0000000000001469","article-title":"HEG1 Is a Highly Specific and Sensitive Marker of Epithelioid Malignant Mesothelioma","volume":"44","author":"JR Naso","year":"2020","journal-title":"Am J Surg Pathol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.21037\/tlcr.2019.11.29","article-title":"Application of immunohistochemistry in diagnosis and management of malignant mesothelioma","volume":"9","author":"DB Chapel","year":"2020","journal-title":"Transl Lung Cancer Res"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1016\/j.ejso.2021.04.012","article-title":"Concerning CT features predict outcome of treatment in patients with malignant peritoneal mesothelioma","volume":"47","author":"PH Sugarbaker","year":"2021","journal-title":"Eur J Surg Oncol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"215","DOI":"10.7326\/0003-4819-117-3-215","article-title":"The serum-ascites albumin gradient is superior to the exudate-transudate concept in the differential diagnosis of ascites","volume":"117","author":"BA Runyon","year":"1992","journal-title":"Ann Intern Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1055\/s-2007-992328","article-title":"Percutaneous management of malignant fluid collections","volume":"24","author":"LS Stokes","year":"2007","journal-title":"Semin Intervent Radiol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"115","DOI":"10.2147\/CMAR.S100210","article-title":"Drainage of malignant ascites: patient selection and perspectives","volume":"9","author":"M Stukan","year":"2017","journal-title":"Cancer Manag Res"}],"container-title":["Zeitschrift f\u00fcr Gastroenterologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2622-2136.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T07:28:22Z","timestamp":1764314902000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2622-2136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":25,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2025,8,4]]},"published-print":{"date-parts":[[2025,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2622-2136","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0044-2771","1439-7803"],"issn-type":[{"value":"0044-2771","type":"print"},{"value":"1439-7803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,24]]}}}