{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:16:38Z","timestamp":1785860198834,"version":"3.56.0"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>For up to eight years after menarche, adolescents are in a developmental stage where PCOS (polycystic ovary syndrome) symptoms are physiological. The diagnostic criteria for PCOS in adult women therefore only partially apply. A new German S2k guideline and the international PCOS guideline of 2023 provide standardized diagnostic criteria for hyperandrogenemia and menstrual disorders in adolescence. The provisional diagnosis of PCOS at risk has been introduced for adolescents who only partially meet the criteria and this diagnosis must be revisited three and eight years after menarche. Recommendations for therapy focus on providing information and lifestyle advice to adolescents and on the prevention and treatment of possible comorbidities such as obesity, insulin resistance and hypertension. This paper presents an overview of a structured diagnostic workup and therapeutic approaches to support adolescents with PCOS.<\/jats:p>","DOI":"10.1055\/a-2622-6321","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T22:54:38Z","timestamp":1754088878000},"page":"927-933","source":"Crossref","is-referenced-by-count":2,"title":["Polycystic Ovary Syndrome \u2013 Support and Prevention in Adolescence"],"prefix":"10.1055","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5494-3328","authenticated-orcid":false,"given":"Katja","family":"Wechsung","sequence":"additional","affiliation":[{"name":"SPZ Interdisziplin\u00e4r, P\u00e4diatrische Endokrinologie und Diabetologie, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Neumann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr p\u00e4diatrische Endokrinologie und Diabetologie, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Balint","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie mit Zentrum f\u00fcr onkologische Chirurgie, Campus Virchow Klinikum, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Wiegand","sequence":"additional","affiliation":[{"name":"SPZ Interdisziplin\u00e4r, P\u00e4diatrische Endokrinologie und Diabetologie, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0002-9378(15)30642-6","article-title":"Amenorrhea associated with bilateral polycystic ovaries","volume":"29","author":"IF Stein","year":"1935","journal-title":"Am J Obstet Gynecol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"247.e1","DOI":"10.1016\/j.ajog.2015.12.013","article-title":"Stein and Leventhal: 80 years on","volume":"214","author":"R Azziz","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e3369","DOI":"10.1210\/clinem\/dgab392","article-title":"Women With Polycystic Ovary Syndrome Have an Increased Risk of Major Cardiovascular Events: a Population Study","volume":"106","author":"TR Berni","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1093\/humrep\/det437","article-title":"The impact of self-reported oligo-amenorrhea and hirsutism on fertility and lifetime reproductive success: results from the Northern Finland Birth Cohort 1966","volume":"29","author":"S West","year":"2014","journal-title":"Hum Reprod"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/S2213-8587(22)00163-2","article-title":"Polycystic ovary syndrome","volume":"10","author":"AE Joham","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41572-024-00511-3","article-title":"Polycystic ovary syndrome","volume":"10","author":"E Stener-Victorin","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41580-023-00680-1","article-title":"White adipocyte dysfunction and obesity-associated pathologies in humans","volume":"25","author":"CE Hagberg","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.1093\/ejendo\/lvae125","article-title":"Prevalence and accurate diagnosis of polycystic ovary syndrome in adolescents across world regions: a systematic review and meta-analysis","volume":"191","author":"ACH Neven","year":"2024","journal-title":"Eur J Endocrinol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.3390\/diagnostics12081931","article-title":"Criteria for Diagnosis of Polycystic Ovary Syndrome during Adolescence: Literature Review","volume":"12","author":"AS Pena","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12916-020-01516-x","article-title":"Adolescent polycystic ovary syndrome according to the international evidence-based guideline","volume":"18","author":"AS Pena","year":"2020","journal-title":"BMC Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"G43","DOI":"10.1093\/ejendo\/lvad096","article-title":"International PCOS Network. 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