{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:44:47Z","timestamp":1771929887865,"version":"3.50.1"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>Background\u2002The management of Mirizzi syndrome has been primarily surgical, but there are no comparisons between surgical and digital single-operator cholangioscopy (dSOC)-guided treatment. The objective of this study was to compare the safety and other outcomes of the two approaches.<\/jats:p>\n                  <jats:p>Methods\u2002A large multicenter international retrospective analysis was conducted comparing dSOC and surgery in patients with type II\u2013IV Mirizzi syndrome between January 2005 and June 2023. Patients with postsurgical anatomy, Mirizzi type I or V, or previous cholecystectomy were excluded.<\/jats:p>\n                  <jats:p>Results\u2002290 patients were included (dSOC, n\u200a=\u200a176; surgery, n\u200a=\u200a114). At baseline, patients undergoing dSOC were older P\u200a=\u200a0.006) and exhibited more co-morbidities. While technical success was lower with dSOC (89.8\u200a% vs. 96.5\u200a%; P\u200a=\u200a0.04), the need for reintervention was comparable after a median follow-up duration of 741.5 days (interquartile range [IQR] 320\u20131781) vs. 346 days (IQR 67\u20131220; P\u200a=\u200a0.009). Overall adverse events (10.2\u200a% vs. 41.2\u200a%; P\u200a&lt;\u200a0.001) and severe adverse events (1.7\u200a% vs. 15.8\u200a%; P\u200a&lt;\u200a0.001) occurred less frequently with dSOC, findings that were confirmed with propensity score-matching. A lower need for hepaticojejunostomy (8.2\u200a% vs. 25.4\u200a%; P\u200a=\u200a0.006) and lower rate of conversion to open surgery (6.0\u200a% vs. 22.8\u200a%; P\u200a=\u200a0.009) were observed in patients undergoing elective cholecystectomy following dSOC compared with the primary surgery group.<\/jats:p>\n                  <jats:p>Conclusions\u2002Our study demonstrates that the use of dSOC for Mirizzi syndrome is effective, showing superior safety despite being used to treat patients with more underlying co-morbidities. dSOC seems valuable in downgrading the extent of subsequent surgery, by potentially reducing the need for hepaticojejunostomy and conversion to open surgery.<\/jats:p>","DOI":"10.1055\/a-2624-2580","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T20:06:28Z","timestamp":1748462788000},"page":"1209-1219","source":"Crossref","is-referenced-by-count":2,"title":["Surgery versus endoscopy with digital single-operator cholangioscopy-guided therapy for Mirizzi syndrome: the SEIZE study"],"prefix":"10.1055","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2039-5022","authenticated-orcid":false,"given":"Michiel","family":"Bronswijk","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium"},{"name":"Department of Gastroenterology and Hepatology, Imelda Hospital Bonheiden, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2077-2591","authenticated-orcid":false,"given":"Joachim","family":"Tengan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6692-7720","authenticated-orcid":false,"given":"Paolo Giorgio","family":"Arcidiacono","sequence":"additional","affiliation":[{"name":"Pancreatobiliary Endoscopy and Endosonography Division, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco J.","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jahnvi","family":"Dhar","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology and Surgical Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-1102","authenticated-orcid":false,"given":"Christian","family":"Gerges","sequence":"additional","affiliation":[{"name":"Department of Interventional Gastroenterological Endoscopy, University Hospital Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Gupta","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology and Surgical Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2654-3164","authenticated-orcid":false,"given":"Marcus","family":"Hollenbach","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Medical Department II, University of Leipzig Medical Center, Leipzig and Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Johnson","sequence":"additional","affiliation":[{"name":"Pancreatobiliary Medicine Unit, University College London Hospitals NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4497-9209","authenticated-orcid":false,"given":"Sundeep","family":"Lakhtakia","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem J.","family":"Lammers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jones A. O.","family":"Omoshoro-Jones","sequence":"additional","affiliation":[{"name":"Surgery Department, Faculty of Health Sciences, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"General and Hepatopancreatobiliary Surgery, Chris Hani-Baragwanath Academic Hospital, Soweto, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apostolis","family":"Papaefthymiou","sequence":"additional","affiliation":[{"name":"Pancreatobiliary Medicine Unit, University College London Hospitals NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8254-7453","authenticated-orcid":false,"given":"Enrique","family":"P\u00e9rez-Cuadrado-Robles","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Georges-Pompidou European Hospital, APHP Centre, University of Paris Cit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Nageshwar","family":"Reddy","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gideon","family":"Saelman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9277-5086","authenticated-orcid":false,"given":"Jayanta","family":"Samanta","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology and Surgical Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7280-1761","authenticated-orcid":false,"given":"Giuseppe","family":"Vanella","sequence":"additional","affiliation":[{"name":"Pancreatobiliary Endoscopy and Endosonography Division, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Waldthaler","sequence":"additional","affiliation":[{"name":"Department of Upper Abdominal Diseases, Karolinska University Hospital and Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0477-4532","authenticated-orcid":false,"given":"Roy L.J.","family":"van Wanrooij","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Fritjof","family":"Willemsen","sequence":"additional","affiliation":[{"name":"Department of Upper Abdominal Diseases, Karolinska University Hospital and Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babs M.","family":"Zonderhuis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rastislav","family":"Kunda","sequence":"additional","affiliation":[{"name":"Department of Surgery, Department of Gastroenterology-Hepatology, Department of Advanced Interventional Endoscopy, Universitair Ziekenhuis Brussel (UZB), Vrije Universiteit Brussel (VUB), Brussels, Belgium"},{"name":"Department of Surgical Gastroenterology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Webster","sequence":"additional","affiliation":[{"name":"Pancreatobiliary Medicine Unit, University College London Hospitals NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schalk","family":"Van der Merwe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the SEIZE collaboration","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"ref1","first-page":"395","volume-title":"Die in meiner Klinik geu\u0308bte Technik der Gallensteinoperationen mit einem Hinweis auf die Indikationen und die Dauererfolge: Auf Grund eigener, bei 1000 Laparotomien gesammelter Erfahrungen","author":"H Kehr","year":"1905"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.3390\/diagnostics11091660","article-title":"The current approach to the diagnosis and classification of 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Dimou","year":"2016","journal-title":"Surgery"}],"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2624-2580.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:31:40Z","timestamp":1761694300000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2624-2580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":20,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,10,28]]},"published-print":{"date-parts":[[2025,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2624-2580","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5,28]]},"published":{"date-parts":[[2025,5,28]]}}}