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The progression of medical therapies, including the discovery and utilization of digitalis, nitrates, aspirin, beta blockers, and statins, is discussed alongside the evolution of catheter-based and surgical interventions such as percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). Future therapies will be briefly discussed. Despite remarkable progress, CAD remains a major public health challenge, emphasizing the importance of continued innovation in prevention, diagnosis, and treatment. Understanding the historical trajectory of CAD provides critical insights for shaping the future of cardiovascular medicine.<\/jats:p>","DOI":"10.1055\/a-2624-5607","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T19:13:21Z","timestamp":1751051601000},"page":"243-252","source":"Crossref","is-referenced-by-count":3,"title":["The History of Coronary Artery Disease"],"prefix":"10.1055","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7165-0305","authenticated-orcid":false,"given":"Andrew J.","family":"Gorton","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery, University of Kentucky, Lexington, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibu P.","family":"Saha","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery, University of Kentucky, Lexington, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"issue":"9921","key":"ref3","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(13)61752-3","article-title":"The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective","volume":"383","author":"S S Mahmood","year":"2014","journal-title":"Lancet"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jcmg.2022.06.018","article-title":"Major global coronary artery calcium guidelines","volume":"16","author":"I S Golub","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jcct.2020.09.005","article-title":"Feasibility of coronary CT angiography for guidance of CABG","volume":"15","author":"A Nykonenko","year":"2021","journal-title":"J Cardiovasc Comput Tomogr"},{"issue":"20","key":"ref6","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1093\/eurheartj\/ehae199","article-title":"Coronary bypass surgery guided by computed tomography in a low-risk population","volume":"45","author":"P W Serruys","year":"2024","journal-title":"Eur Heart J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.carrev.2021.03.025","article-title":"Robotic-assisted PCI: the future of coronary intervention?","volume":"35","author":"A Stevenson","year":"2022","journal-title":"Cardiovasc Revasc Med"},{"issue":"09","key":"ref8","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.amjmed.2014.04.015","article-title":"The epidemic of the 20(th) century: coronary heart disease","volume":"127","author":"J E Dalen","year":"2014","journal-title":"Am J Med"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.suc.2022.01.007","article-title":"Epidemiology of coronary artery disease","volume":"102","author":"J P Duggan","year":"2022","journal-title":"Surg Clin North Am"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/HEARTVIEWS.HEARTVIEWS_57_17","article-title":"Coronary heart disease: from mummies to 21st century","volume":"18","author":"R Hajar","year":"2017","journal-title":"Heart Views"},{"issue":"03","key":"ref11","first-page":"223","article-title":"The discovery of the body: human dissection and its cultural contexts in ancient Greece","volume":"65","author":"H von Staden","year":"1992","journal-title":"Yale J Biol Med"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4471-4531-8","volume-title":"Leonardo's Heart","author":"F C Wells","year":"2013"},{"issue":"02","key":"ref15","first-page":"260","article-title":"Andreas Vesalius 500 years\u2014a Renaissance that revolutionized cardiovascular knowledge","volume":"30","author":"E T Mesquita","year":"2015","journal-title":"Braz J Cardiovasc Surg"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2040-2384-1-3","article-title":"William Harvey and the discovery of the circulation of the blood","volume":"1","author":"D Ribatti","year":"2009","journal-title":"J Angiogenes Res"},{"issue":"S 04","key":"ref17","first-page":"56","article-title":"History of coronary heart disease","volume":"91","author":"P R Lichtlen","year":"2002","journal-title":"Z Kardiol"},{"issue":"05","key":"ref18","first-page":"e444","article-title":"Ren\u00e9 Th\u00e9ophile Hyacinthe La\u00ebnnec (1781-1826). 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