{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:35:21Z","timestamp":1777332921084,"version":"3.51.4"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Central Council for Research in Homoeopathy, under the Ministry of Ayush, Government of India, New Delhi"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Homeopathy"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clinical verification in homeopathy is a systematic process that aims to validate the therapeutic efficacy of homeopathic medicines. The Central Council for Research in Homoeopathy (CCRH) has been conducting clinical verification studies in lesser known, fragmentarily proved and rare medicines such as Acorus calamus through its Clinical Verification Program, thereby expanding the therapeutic utility of these medicines.<\/jats:p>\n                  <jats:p>The primary objective of the study was to assess the change in intensity of presenting symptoms of the participants after administration of the medicine Acorus calamus by measuring change in Measure Yourself Medical Outcome Profile-2 (MYMOP-2) profile score. The study also aimed to evaluate overall impact on participants' daily living using the Outcome in Relation to Impact on Daily Living (ORIDL) scale, as well as to identify any new clinical symptoms that were not elicited during the drug proving.<\/jats:p>\n                  <jats:p>A multi-center open-label study was conducted at the outpatient departments of the 14 hospitals\/clinics of the CCRH located in different states of India. Participants having a minimum of three symptoms corresponding to the proving symptom of Acorus calamus were included in the study.<\/jats:p>\n                  <jats:p>Improvement in the symptomatology of 321 participants who completed a minimum of two follow-ups suggested the effectiveness of the medicine in treating various clinical conditions, including headache, constipation, respiratory diseases such as rhinitis, acute nasopharyngitis, sinusitis and cough, musculoskeletal disorders such as myalgia, arthralgia and cervical spondylosis, and skin conditions such as eczema. Acorus calamus showed substantial therapeutic potential, with significant improvement (p\u2009&lt;\u20090.0001) in MYMOP-2 and in ORIDL scores. Symptoms that were not previously identified during the drug proving included sneezing and difficulty in breathing.<\/jats:p>\n                  <jats:p>The study successfully verified the symptomatology of Acorus calamus by ascertaining improvement in symptoms after its administration in individuals with various health conditions. Future research can focus on randomized controlled trials to quantify the efficacy of Acorus calamus for the indicated clinical conditions.<\/jats:p>","DOI":"10.1055\/a-2625-0202","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T22:49:12Z","timestamp":1757371752000},"page":"078-088","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Homeopathic Therapeutic Potential of Acorus calamus: A Multi-center Open-Label Clinical Verification Study"],"prefix":"10.1055","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6809-9364","authenticated-orcid":false,"given":"Suhana Panaparambil","family":"Azis","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Central Council for Research in Homeopathy Headquarters, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charu","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Central Council for Research in Homeopathy Headquarters, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Partha Sarathi","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Dr. Anjali Chatterjee Regional Research Institute for Homeopathy, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasanta Kumar","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Regional Research Institute for Homeopathy, Puri, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Punam","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Dr. D.P. Rastogi Central Research Institute of Homeopathy, Noida, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaushal Kumar","family":"Savera","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, National Homeopathy Research Institute in Mental Health, Kottayam, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Central Research Institute (Homeopathy), Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratan Chandra","family":"Shil","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Regional Research Institute for Homeopathy, Agartala, Tripura, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumar Keshav","family":"Avinash","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Clinical Verification Unit (Homeopathy), Patna, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil S.","family":"Ramteke","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Central Council for Research in Homeopathy Headquarters, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amulya Ratna","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Regional Research Institute for Homeopathy, Guwahati, Assam, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tejaswini Patole","family":"Kamble","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Regional Research Institute for Homeopathy, Navi Mumbai, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uttam","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Central Research Institute (Homeopathy), Jaipur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh","family":"Sah","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Central Research Institute (Homeopathy), Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjit","family":"Sonny","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Regional Research Institute for Homeopathy, Siliguri, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyi","family":"Karso","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Regional Research Institute for Homeopathy, Guwahati, Assam, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibha","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Clinical Verification Unit (Homeopathy), Patna, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Central Research Institute (Homeopathy), Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh Kumar","family":"Rana","sequence":"additional","affiliation":[{"name":"Statistical Section, Central Council for Research in Ayurvedic Sciences Headquarters, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kusum","family":"Lata","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Central Council for Research in Homeopathy Headquarters, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beenu","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Central Council for Research in Homeopathy Headquarters, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satarupa","family":"Sadhukhan","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Dr. Anjali Chatterjee Regional Research Institute for Homeopathy, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renu","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Dr. D.P. Rastogi Central Research Institute of Homeopathy, Noida, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann Maria","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, National Homeopathy Research Institute in Mental Health, Kottayam, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manila","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Clinical Verification Unit (Homeopathy), Patna, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meera","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Central Research Institute (Homeopathy), Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gauri","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Botany, University of Lucknow, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhash","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Clinical Verification, Central Council for Research in Homeopathy Headquarters, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4103\/0973-8258.122053","article-title":"Sweet flag (Acorus calamus Linn.): an incredible medicinal herb","volume":"7","author":"H Imam","year":"2013","journal-title":"Int J Green Pharm"},{"key":"ref2","volume-title":"Plants: Homeopathic and Medicinal Uses from a Botanical Family Perspective","author":"F Vermeulen","year":"2011"},{"key":"ref3","first-page":"182","article-title":"A critical review of Vacha (Acorus calamus L.) in ayurvedic & modern context","volume":"8","author":"S Singh","year":"2022","journal-title":"World J Pharm Med Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1080\/14786419.2014.915827","article-title":"Acorus calamus (The Healing Plant): a review on its medicinal potential, micropropagation and conservation","volume":"28","author":"V Sharma","year":"2014","journal-title":"Nat Prod Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.3390\/jcm9041176","article-title":"Role of Vacha (Acorus calamus Linn.) in neurological and metabolic disorders: evidence from ethnopharmacology, phytochemistry, pharmacology and clinical study","volume":"9","author":"V Sharma","year":"2020","journal-title":"J Clin Med"},{"key":"ref6","first-page":"882","article-title":"Anti-inflammatory activity of 80% ethanolic extract of Acorus calamus Linn. leaves in albino rats","volume":"3","author":"D K Jain","year":"2010","journal-title":"Research J Pharm Tech"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jep.2010.07.024","article-title":"Bronchodilatory effect of Acorus calamus (Linn.) is mediated through multiple pathways","volume":"131","author":"A J Shah","year":"2010","journal-title":"J Ethnopharmacol"},{"key":"ref8","first-page":"445","volume-title":"Evaluation of gastric ulcer protective activity of Acorus calamus Linn. in laboratory animals","author":"C C Barua","year":"2015"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S2221-1691(12)60341-4","article-title":"Antidiabetic activity of methanol extract of Acorus calamus in STZ induced diabetic rats","volume":"2","author":"D H Prisilla","year":"2012","journal-title":"Asian Pac J Trop Biomed"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.phymed.2013.09.020","article-title":"An overview on traditional uses and pharmacological profile of Acorus calamus Linn. 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