{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T10:07:01Z","timestamp":1782468421710,"version":"3.54.5"},"reference-count":62,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Linksherzerkrankungen (LHD) sind die h\u00e4ufigste Ursache einer pulmonalen Hypertonie (PH), die weiter in isolierte postkapill\u00e4re PH (IpcPH) und kombinierte pr\u00e4- und postkapill\u00e4re PH (CpcPH) unterteilt wird.<\/jats:p><jats:p>Mit dem Ziel Behandlungsans\u00e4tzen n\u00e4herzukommen, setzte die PH-LHD-Arbeitsgruppe des 7.\u2006Welt-Symposiums zur pulmonalen Hypertonie einen st\u00e4rkeren Fokus auf die Ph\u00e4notypisierung, Subtypisierung und die ausdifferenziertere Betrachtungsweise des breiten Spektrums der PH-LHD. Mit dieser Intention wurde ein 4-stufiges PH-LHD-System erarbeitet, in dem jede Stufe (A\u200a=\u200aRisiko, B\u200a=\u200astrukturelle Herzerkrankung, C\u200a=\u200asymptomatische Herzerkrankung, D\u200a=\u200afortgeschritten) durch spezifische pathophysiologische, h\u00e4modynamische, klinische und letztendlich auch therapeutische Strategien gekennzeichnet ist. In diesem Kontext wird zudem auf zur PH-LHD f\u00fchrende kardiologische Krankheitsbilder mit spezifischen Therapieans\u00e4tzen, wie die Mitral- und Aortenklappenstenose sowie ausgew\u00e4hlte Kardiomyopathien, ein Augenmerk gerichtet. Ebenso wird die \u00dcberschneidung mit anderen PH-Gruppen wie der CTEPH und der PH bei Lungenerkrankungen betont und konkretisiert. Der therapeutische Einsatz von PAH-Medikamenten, die einen pulmonalvaskul\u00e4ren Ansatz haben, kann anhand von Ergebnissen randomisierter klinischer Studien weiterhin au\u00dferhalb klinischer Studien nicht empfohlen werden.<\/jats:p>","DOI":"10.1055\/a-2625-4920","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T22:42:36Z","timestamp":1759790556000},"page":"787-796","source":"Crossref","is-referenced-by-count":1,"title":["Pulmonale Hypertonie bei Linksherzerkrankungen"],"prefix":"10.1055","volume":"79","author":[{"given":"Kai Helge","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Kardiologie, Kardiologie I, Universit\u00e4tsmedizin Mainz, Mainz, Deutschland"},{"name":"Centrum f\u00fcr Thrombose und H\u00e4mostase (CTH), Universit\u00e4tsmedizin Mainz, Mainz, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Adler","sequence":"additional","affiliation":[{"name":"Klinik III f\u00fcr Innere Medizin, Uniklinik K\u00f6ln, K\u00f6ln, Deutschland"},{"name":"Klinik f\u00fcr Pneumologie, Kliniken Maria Hilf M\u00f6nchengladbach, M\u00f6nchengladbach, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olympia","family":"Bikou","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I, LMU Klinikum, LMU M\u00fcnchen, M\u00fcnchen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Felgendreher","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie, KRH Standort Neustadt am R\u00fcbenberge, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hohenforst-Schmidt","sequence":"additional","affiliation":[{"name":"Innere II, M\u00e4rkische Kliniken, L\u00fcdenscheid, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Holt","sequence":"additional","affiliation":[{"name":"Praxis am Steintor, Recklinghausen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz X.","family":"Kleber","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Ladage","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Pneumologie, Kliniken Maria Hilf M\u00f6nchengladbach, M\u00f6nchengladbach, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Lichtblau","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Pneumologie, Zentrum f\u00fcr Pulmonale Hypertonie, Universit\u00e4tsspital, Z\u00fcrich, Schweiz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Pfeuffer-Jovic","sequence":"additional","affiliation":[{"name":"Klinikum W\u00fcrzburg Mitte, Standort Missioklinik W\u00fcrzburg, W\u00fcrzburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Pott","sequence":"additional","affiliation":[{"name":"II. 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