{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T23:32:01Z","timestamp":1764631921507,"version":"3.46.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Inhalative Kortikosteroide (ICS) werden als leitliniengerechte Therapie bei Asthma bronchiale sowie einer chronisch obstruktiven pulmonalen Erkrankung (COPD) eingesetzt. Unerw\u00fcnschte Wirkungen dieser Arzneimitteltherapie sind oropharyngeale und laryngeale Candidosen und die chronische Laryngitis. Das inhalative Kortikosteroid Ciclesonid entfaltet als Prodrug seine aktive Wirkung erst in der Lunge. Die Reduktion oropharyngealer Candidosen wurde bereits unter Ciclesonid beschrieben, und ein m\u00f6glicher positiver Effekt auf Kehlkopfschleimh\u00e4ute sollte nun gepr\u00fcft werden.<\/jats:p>\n                  <jats:p>Videolupenlaryngoskopische und -stroboskopische Aufzeichnungen sowie Stimmanalysen wurden nach ICS-Umstellung retrospektiv befundet. Die Kontrollgruppen beinhalteten Patienten*innen, die keine Umstellung vorgenommen oder ihr ICS abgesetzt hatten.<\/jats:p>\n                  <jats:p>Die statistische Auswertung zeigte, dass alle 3 Patient*innengruppen zwischen Erstdiagnose und Verlaufskontrolle eine Tendenz zur Funktions- und Befundbesserung des Larynx aufwiesen. Die Ergebnisse waren nicht von statistischer Signifikanz.<\/jats:p>\n                  <jats:p>Die Ursachen f\u00fcr eine chronische Laryngitis sind h\u00e4ufig multifaktoriell (Rauchen, ICS, Reflux, Diabetes). Die Umstellung des ICS auf Ciclesonid ist ein Teilaspekt bei der Therapie der chronischen Laryngitis, dessen Anwendung anstelle eines anderen ICS zur Therapie pulmonaler Erkrankungen scheint unerw\u00fcnschte laryngeale Wirkungen zu reduzieren. Bereits eine umfassende fach\u00e4rztliche Beratung und Anleitung zur Schleimhauthygiene scheint einen positiven Therapieeffekt zu haben.<\/jats:p>","DOI":"10.1055\/a-2625-8120","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T18:56:01Z","timestamp":1750100161000},"page":"782-791","source":"Crossref","is-referenced-by-count":0,"title":["Multifaktorielle Genese der chronischen Laryngitis \u2013 Einfluss der inhalativen Kortikosteroide"],"prefix":"10.1055","volume":"104","author":[{"given":"Shabnam","family":"Shahpasand","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Phoniatrie und P\u00e4daudiologie, Universit\u00e4tsklinikum M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nele Josefine","family":"Reuting","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Universit\u00e4tsmedizin G\u00f6ttingen, Phoniatrie und P\u00e4daudiologie, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Olthoff","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Universit\u00e4tsmedizin G\u00f6ttingen, Phoniatrie und P\u00e4daudiologie, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"g5827","DOI":"10.1136\/bmj.g5827","article-title":"Laryngitis","volume":"349","author":"JM Wood","year":"2014","journal-title":"BMJ"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1055\/s-0028-1100390","article-title":"Chronische Laryngitis--assoziierte Faktoren und subjektive Stimmeinsch\u00e4tzung","volume":"88","author":"R Reiter","year":"2009","journal-title":"Laryngorhinootologie"},{"volume-title":", Hrsg. 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