{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:29:08Z","timestamp":1776439748125,"version":"3.51.2"},"reference-count":63,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Facial Plast Surg"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurotoxins and fillers have become increasingly popular for restoring age-related changes in the perioral region. This review examines their roles in optimizing perioral rejuvenation.<\/jats:p><jats:p>The perioral region composes the lower third and middle three-fifths of the face. It includes the lips, surrounding perioral skin, chin, muscles of facial expression, maxilla, and mandible. Changes in the perioral region are significant contributors to the visible signs of aging.<\/jats:p><jats:p>Ideal candidates for perioral rejuvenation with toxin and filler are individuals experiencing age-related rhytids or volume loss who are interested in minimally invasive, nonsurgical interventions.<\/jats:p><jats:p>Neurotoxins like Botox, Xeomin, Dysport, Jeuveau, and Daxxify are used to relax muscles that contribute to rhytids. Common treatment areas and techniques include perioral rhytids, lip flip, oral commissure elevation, dimpled chin, and gummy smile. Dermal fillers such as hyaluronic acid, calcium hydroxyapatite, and poly-L-lactic acid restore volume in areas like the nasolabial folds, lips, marionette lines, chin, prejowl sulcus, and perioral rhytids.<\/jats:p><jats:p>Neurotoxins and dermal fillers offer effective, minimally invasive solutions for perioral rejuvenation. With an understanding of underlying anatomy, proper patient selection, and precise injection techniques, facial plastic surgeons can achieve natural, youthful results with minimal downtime.<\/jats:p>","DOI":"10.1055\/a-2626-9218","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T19:11:33Z","timestamp":1750705893000},"page":"637-649","source":"Crossref","is-referenced-by-count":1,"title":["The Role of Toxins and Fillers in Optimizing Perioral Rejuvenation"],"prefix":"10.1055","volume":"41","author":[{"given":"F. Jeffrey","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head & Neck Surgery, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather K.","family":"Schopper","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head & Neck Surgery, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott G.","family":"Walen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head & Neck Surgery, Penn State Health Milton S Hershey Medical Center, Hershey, 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