{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:35:42Z","timestamp":1790012142983,"version":"4.0.1"},"reference-count":137,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"Foundation of Liaoning Educational Committee of China","award":["grant number LJ232410164021"],"award-info":[{"award-number":["grant number LJ232410164021"]}]},{"name":"the Screening of small-molecule tumor suppression compounds project","award":["grant number SDUZHHT\u30142022\u30152448"],"award-info":[{"award-number":["grant number SDUZHHT\u30142022\u30152448"]}]},{"name":"the Shenyang Youth Science and Technology Innovation Project","award":["grant number RC220177"],"award-info":[{"award-number":["grant number RC220177"]}]},{"name":"The Science and Technology Project of Hunan Province","award":["grant number 2023JJ40882"],"award-info":[{"award-number":["grant number 2023JJ40882"]}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["grant number 31800688"],"award-info":[{"award-number":["grant number 31800688"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Foundation of Liaoning Educational Committee of China","award":["grant number JYTMS20230765"],"award-info":[{"award-number":["grant number JYTMS20230765"]}]},{"name":"the Science and Technology Project of Department of Science & Technology of Liaoning province of China","award":["grant number 2024-MSLH-185"],"award-info":[{"award-number":["grant number 2024-MSLH-185"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by the accumulation of synovial fluid in joints, synovial inflammation, and cartilage damage. With the development of the disease, it may result in joint deformity, which affects the normal joint function of patients and seriously endangers people\u02bcs life and health. According to statistics, the incidence of rheumatoid arthritis increases with age. However, there is currently no drug that can completely cure rheumatoid arthritis; only through certain drugs and measures can the progression of the disease be delayed. Plant-derived bioactive substances have garnered extensive research attention for their therapeutic potential in treating various diseases. Studies have shown that plant-derived bioactive substances play an important role in preventing rheumatoid arthritis. This review comprehensively and systematically evaluates plant-derived bioactive substances with anti-arthritic properties,\n          specifically focusing on bioactive substances including flavonoids, polyphenols, terpenes, alkaloids, phenols, quinones, and phenylpropanoids, and elucidates their mechanisms of action to provide reference for the prevention and treatment of rheumatoid arthritis.<\/jats:p>","DOI":"10.1055\/a-2627-4183","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:41:38Z","timestamp":1762299698000},"page":"465-482","source":"Crossref","is-referenced-by-count":1,"title":["Plant-derived Bioactive Substances with Anti-rheumatoid Arthritis Properties"],"prefix":"10.1055","volume":"92","author":[{"given":"Haoyue","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Life Science, Liaoning University, Shenyang, China"},{"name":"College of Life Science, Liaoning University, Shenyang, China; Shenyang Key Laboratory of Chronic Disease Occurrence and Nutrition Intervention, College of Life Sciences, Liaoning University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Life Science, Liaoning University, Shenyang, China"},{"name":"College of Life Science, Liaoning University, Shenyang, China; Shenyang Key Laboratory of Chronic Disease Occurrence and Nutrition Intervention, College of Life Sciences, Liaoning University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoya","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Life Science, Liaoning University, Shenyang, China"},{"name":"College of Life Science, Liaoning University, Shenyang, China; Shenyang Key Laboratory of Chronic Disease Occurrence and Nutrition Intervention, College of Life Sciences, Liaoning University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Life Science, Liaoning University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujiahua","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Life Science, Liaoning University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiwei","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Life Science, Liaoning University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Science, Liaoning University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Ganzhou, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Bi","sequence":"additional","affiliation":[{"name":"College of Life Science, Liaoning University, Shenyang, China"},{"name":"College of Life Science, Liaoning University, Shenyang, China; Shenyang Key Laboratory of Chronic Disease Occurrence and Nutrition Intervention, College of Life Sciences, Liaoning University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Geriatric General Practice, The Second Affiliated Hospital of Shenyang Medical College, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Life Science, Liaoning University, Shenyang, China"},{"name":"College of Life Science, Liaoning University, Shenyang, China; Shenyang Key Laboratory of Chronic Disease Occurrence and Nutrition Intervention, College of Life Sciences, Liaoning University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"ref1","first-page":"1707","article-title":"Pathogenesis of rheumatoid arthritis: One year in review 2024","volume":"42","author":"A D\u02bcOrazio","year":"2024","journal-title":"Clin Exp Rheumatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1394108","DOI":"10.3389\/fimmu.2024.1394108","article-title":"Macrophage polarization in rheumatoid arthritis: Signaling pathways, metabolic reprogramming, and crosstalk with synovial fibroblasts","volume":"15","author":"Y Zheng","year":"2024","journal-title":"Front 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