{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:07:52Z","timestamp":1771286872517,"version":"3.50.1"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die Keimzelltumoren (KZT) sind die h\u00e4ufigsten Neoplasien im Hoden und lassen sich in Abh\u00e4ngigkeit vom Manifestationsalter, der Molekularbiologie und der Histomorphologie in Typ-I-, Typ-II- und Typ-III-Tumoren einteilen. Insgesamt gibt es dabei 6 histologische Subtypen, die unterschiedlich innerhalb dieser 3 Gruppen verteilt sind: Seminome, embryonale Karzinome, Chorionkarzinome, Dottersacktumoren, Teratome und spermatozyt\u00e4re Tumoren. Am h\u00e4ufigsten sind die malignen Typ-II-KZT, die prim\u00e4r meist durch eine radikale Orchiektomie therapiert werden. In F\u00e4llen kleiner Tumoren, bei denen z.B. aufgrund negativer Serumtumormarker unklar ist, ob ein maligner oder benigner Hodentumor (z.B. Epidermiszyste, Keimstranggonadenstromatumor, Adenomatoidtumor, andere testikul\u00e4re Adnextumoren) vorliegt, kann zun\u00e4chst eine Enukleation mit anschlie\u00dfender Schnellschnittuntersuchung erfolgen, da f\u00fcr benigne Tumoren eine hodenerhaltende Tumorresektion ausreicht. Die genaue Einteilung der KZT erfolgt dann histopathologisch durch die morphologischen Charakteristika der KZT-Subtypen und kann unter gewissen Umst\u00e4nden durch immunhistochemische Analysen erg\u00e4nzt werden. Bei der Untersuchung von Resektaten aus Metastasen (z.B. retroperitoneale Lymphknoten) k\u00f6nnen auch biologische Sonderformen, wie eine somatische Malignit\u00e4t oder das sogenannte \u201eGrowing-Teratoma\u201c-Syndrom detektiert werden. Sollten histomorphologisch Anteile der typischen KZT-Subtypen in somatischen Malignit\u00e4ten fehlen, kann der KZT-Ursprung molekularpathologisch durch Nachweis des Isochromosoms 12p oder einer Vermehrung chromosomalen Materials auf Chromosom 12 best\u00e4tigt werden.<\/jats:p>","DOI":"10.1055\/a-2629-0269","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T23:31:13Z","timestamp":1758670273000},"page":"38-45","source":"Crossref","is-referenced-by-count":0,"title":["Keimzelltumoren des Hodens: Klassifikation, Schnellschnittdiagnostik, Sentinel-Lymphknoten-Biopsie und biologische Sonderformen"],"prefix":"10.1055","volume":"57","author":[{"given":"Alexander","family":"Fichtner","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie, Universit\u00e4tmedizin G\u00f6ttingen, G\u00f6ttingen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Che","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Urologie, Medizinische Fakult\u00e4t und Universit\u00e4tsklinikum D\u00fcsseldorf, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, D\u00fcsseldorf, Deutschland"},{"name":"Centrum f\u00fcr Integrierte Onkologie (CIO) D\u00fcsseldorf, CIO Aachen Bonn K\u00f6ln D\u00fcsseldorf, D\u00fcsseldorf, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Nettersheim","sequence":"additional","affiliation":[{"name":"Urologisches Forschungslabor, Translationale Uro-Onkologie, Klinik f\u00fcr Urologie, Medizinische Fakult\u00e4t und Universit\u00e4tskrankenhaus, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, D\u00fcsseldorf, Deutschland"},{"name":"Lighthouse Projekt: Keimzelltumoren, Zentrum f\u00fcr integrierte Onkologie Aachen, Bonn und K\u00f6ln-D\u00fcsseldorf (CIO ABCD), D\u00fcsseldorf, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Bremmer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie, Universit\u00e4tmedizin G\u00f6ttingen, G\u00f6ttingen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"H Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012390","article-title":"Recent global trends in testicular cancer incidence and mortality","volume":"97","author":"JS Park","year":"2018","journal-title":"Medicine 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