{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T23:10:06Z","timestamp":1751929806037,"version":"3.41.2"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the study was to explore the relationship between hormone levels and\n                    coagulation indicators in patients with Cushing\u2019s syndrome, providing insights\n                    into disease progression and treatment. We recruited 640 patients diagnosed with\n                    ACTH-independent Cushing\u2019s syndrome with adrenocortical tumors, conducting\n                    comprehensive physical and laboratory examinations, and analyzing data using\n                    logistic regression models. We found that compound F at 8 AM (F8AM) and ACTH had\n                    better correlation with coagulation characteristics. We revealed negative\n                    association between F8AM levels and PLT or APTT, while ACTH exhibited opposite\n                    trends. With F8AM increasing, Fbg declined significantly, while ACTH had the\n                    opposite association. In patients with Cushing\u2019s syndrome, chronic cortisol\n                    elevations may lead to consumptive coagulopathy, characterized by decreased PLT\n                    and Fbg levels, apart from the hypercoagulable state implied by decreased\n                    APTT.<\/jats:p>","DOI":"10.1055\/a-2630-1124","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T22:42:37Z","timestamp":1751928157000},"page":"373-377","source":"Crossref","is-referenced-by-count":0,"title":["Correlation Between Coagulation Index and Hormone Levels in Patients\n                    with ACTH-Independent Cushing's Syndrome"],"prefix":"10.1055","volume":"57","author":[{"given":"Yanan","family":"Li","sequence":"first","affiliation":[{"name":"Urology Department, Peking Union Medical College\n                    Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhao","sequence":"first","affiliation":[{"name":"Urology Department, Peking Union Medical College\n                    Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Urology Department, Peking Union Medical College\n                    Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Urology Department, Peking Union Medical College\n                    Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0140-6736(16)31280-6","article-title":"Cushing\u2019s syndrome","volume":"388","author":"R Barnett","year":"2016","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000314349","article-title":"Coagulopathy in Cushing\u2019s syndrome","volume":"92","author":"L Trementino","year":"2010","journal-title":"Neuroendocrinology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0140-6736(14)61375-1","article-title":"Cushing\u2019s syndrome","volume":"386","author":"A Lacroix","year":"2015","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1126\/science.1252328","article-title":"Recurrent somatic mutations underlie corticotropin-independent Cushing\u2019s\n                    syndrome","volume":"344","author":"Y Sato","year":"2014","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"763076","DOI":"10.3389\/fnut.2021.763076","article-title":"Dietary magnesium intake affects the association between serum vitamin D and\n                    type 2 diabetes: a cross-sectional study","volume":"8","author":"W Huang","year":"2021","journal-title":"Front Nutr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF03345709","article-title":"Blood coagulation and fibrinolysis in patients with Cushing\u2019s syndrome:\n                    increased plasminogen activator inhibitor-1, decreased tissue factor pathway\n                    inhibitor, and unchanged thrombin-activatable fibrinolysis inhibitor levels","volume":"32","author":"C Erem","year":"2009","journal-title":"J Endocrinol Invest"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1530\/EJE-10-0583","article-title":"Changes in coagulation indexes and occurrence of venous thromboembolism in\n                    patients with Cushing\u2019s syndrome: results from a prospective study before and\n                    after surgery","volume":"163","author":"L Manetti","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1007\/s11102-022-01261-9","article-title":"Hypercoagulability in Cushing\u2019s syndrome: incidence, pathogenesis and need for\n                    thromboprophylaxis protocols","volume":"25","author":"R A Feelders","year":"2022","journal-title":"Pituitary"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1056\/NEJMoa1107477","article-title":"C-reactive protein, fibrinogen, and cardiovascular disease prediction","volume":"367","author":"S Kaptoge","year":"2012","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1182\/blood.2020007208","article-title":"Disseminated intravascular coagulation and its immune mechanisms","volume":"139","author":"N I Popescu","year":"2022","journal-title":"Blood"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1210\/jc.2009-0290","article-title":"Hypercoagulable state in Cushing\u2019s syndrome: a systematic review","volume":"94","author":"B Van Zaane","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1182\/blood-2005-04-1723","article-title":"Ligand-specific glucocorticoid receptor activation in human platelets","volume":"106","author":"L A Moraes","year":"2005","journal-title":"Blood"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4142\/jvs.2011.12.3.215","article-title":"Effects of hydrocortisone and aminophylline on the aggregation of equine\n                    platelets in vitro","volume":"12","author":"S Casella","year":"2011","journal-title":"J Vet Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/cvr\/cvy044","article-title":"Non-genomic effects of nuclear receptors: insights from the anucleate\n                    platelet","volume":"114","author":"A J Unsworth","year":"2018","journal-title":"Cardiovasc Res"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2630-1124.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T22:42:50Z","timestamp":1751928170000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2630-1124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":14,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2025,7,7]]},"published-print":{"date-parts":[[2025,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2630-1124","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}