{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:14:28Z","timestamp":1790835268292,"version":"4.1.0"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>ST elevation myocardial infarction (STEMI) patients display endothelial dysfunction. We investigated whether endothelial glycocalyx thickness is affected in STEMI patients and may predict left ventricular performance post event.<\/jats:p>\n                  <jats:p>We examined 278 STEMI patients and 140 matched controls. We measured: (a) perfused boundary region (PBR) of the sublingual microvessels (range 4 to 25 \u03bcm; increased value indicates reduced endothelial glycocalyx integrity) at baseline; (b) left ventricular ejection fraction (LVEF) and global longitudinal strain (LVGLS), at baseline and at 12 months, (c) the percentage change of left ventricular end-systolic volume (\u0394LVESV) at 12 months.<\/jats:p>\n                  <jats:p>Compared with matched controls, STEMI patients had higher PBR4\u201325 (2.11\u2009\u00b1\u20090.17 \u03bcm vs. 1.98\u2009\u00b1\u20090.20 \u03bcm, p\u2009&lt;\u20090.001). In a model including age, sex, hypertension, diabetes, hyperlipidemia, smoking, family history of coronary artery disease, number of diseased vessels, location of STEMI medication, and high-sensitivity troponin T (hs-troponin), PBR4\u201325 was independently associated with LVEF and LVGLS at 48\u2009hours post-MI (for LVEF: unstandardized \u03b2 coefficient: \u22124.71, 95% CI: \u22128.53 to \u22120.71, p\u2009=\u20090.019 and for LVGLS: 2.89, 95%CI: 1.63\u20134.16, p\u2009&lt;\u20090.001). Using multivariable analysis, PBR4\u201325 remained a significant predictor of the percentage change in LVEF, LVGLS, and \u0394LVESV at 12-month follow-up (LVEF change: unstandardized \u03b2 coefficient: \u22121.38, 95% CI: \u22121.80 to \u22120.96, p\u2009&lt;\u20090.001; for LV GLS change: \u22120.66, 95% CI: \u22121.14 to \u22120.18, p\u2009=\u20090.007 and for \u0394LVESV: 1.42, 95% CI: 0.06\u20132.93, p\u2009=\u20090.039). A PBR4\u201325 cut-off value of 2.29 \u03bcm could detect LV EF less than 45% at 48\u2009h as well as at 12 months (AUC: 0.82, p\u2009&lt;\u20090.001 and AUC: 0.80; p\u2009&lt;\u20090.001).<\/jats:p>\n                  <jats:p>Endothelial glycocalyx assessment is associated with myocardial performance after STEMI.<\/jats:p>","DOI":"10.1055\/a-2632-3249","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T11:02:16Z","timestamp":1752231736000},"page":"383-393","source":"Crossref","is-referenced-by-count":1,"title":["Association of Endothelial Glycocalyx Integrity with Left Ventricular Performance and Remodeling after Acute Myocardial Infarction: A 12-month Follow-up Study"],"prefix":"10.1055","volume":"126","author":[{"given":"John","family":"Thymis","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, School of Medicine University General Hospital \u201cAttikon,\u201d National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Katogiannis","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, School of Medicine University General Hospital \u201cAttikon,\u201d National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Pavlidis","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, School of Medicine University General Hospital \u201cAttikon,\u201d National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Vlastos","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, School of Medicine University General Hospital \u201cAttikon,\u201d National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damianos","family":"Tsilivarakis","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, School of Medicine University General Hospital \u201cAttikon,\u201d National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavriella","family":"Kostelli","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, School of Medicine University General Hospital \u201cAttikon,\u201d National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Parissis","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, School of Medicine University General Hospital \u201cAttikon,\u201d National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota Efstathia","family":"Nikolaou","sequence":"additional","affiliation":[{"name":"School of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Andreadou","sequence":"additional","affiliation":[{"name":"School of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaia","family":"Lambadiari","sequence":"additional","affiliation":[{"name":"2nd Department of Internal-Medicine, Diabetes Centre, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8241-7886","authenticated-orcid":false,"given":"Ignatios","family":"Ikonomidis","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, School of Medicine University General Hospital \u201cAttikon,\u201d National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","article-title":"Endothelial function and dysfunction: testing and clinical relevance","volume":"115","author":"J E Deanfield","year":"2007","journal-title":"Circulation"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.3390\/ijms19123838","article-title":"Endothelial function: a short guide for the interventional cardiologist","volume":"19","author":"T Gori","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"e14351","DOI":"10.14814\/phy2.14351","article-title":"Noninvasive sublingual microvascular imaging reveals sex-specific reduction in glycocalyx 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