{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T12:24:00Z","timestamp":1776255840706,"version":"3.50.1"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"08\/09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gesundheitswesen"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Besiedelung mit Streptokokken der Gruppe B (GBS) betrifft etwa 13 Prozent\n                        der Schwangeren und erh\u00f6ht das Risiko f\u00fcr peripartal erworbene Infektionen\n                        des Neugeborenen, einen vorzeitigen Blasensprung und Fr\u00fchgeburt.\n                        GBS-Infektionen sind eine Hauptursache f\u00fcr neonatale Sepsis. Insbesondere\n                        die fr\u00fch auftretende GBS-Infektion (EOGBS) in den ersten sieben Lebenstagen\n                        kann f\u00fcr Neugeborene sehr gef\u00e4hrlich sein. Zur Pr\u00e4vention einer Infektion\n                        des Neugeborenen erhalten Personen mit einem positiven GBS-Screening w\u00e4hrend\n                        der Schwangerschaft eine intrapartale Antibiotikaprophylaxe. Die\n                        Risikoabsch\u00e4tzung erfolgt bei Schwangeren durch ein universelles\n                        GBS-Screening mittels vaginalen und rektalen Abstriches, durch die\n                        Untersuchung m\u00fctterlicher Risikofaktoren f\u00fcr EOGBS als risikobasierte\n                        Strategie oder durch eine Kombination beider Strategien.<\/jats:p><jats:p>Die Empfehlung der Weltgesundheitsorganisation (WHO) zielt darauf ab, die\n                        Qualit\u00e4t der Versorgung und die Gesundheit von Schwangeren und Neugeborenen\n                        durch die Pr\u00e4vention von EOGBS-Erkrankungen zu verbessern. Die Entwicklung\n                        geeigneter Screening-Strategien f\u00fcr GBS zur Einleitung der intrapartalen\n                        Antibiotikaprophylaxe soll dabei eine wesentliche Rolle spielen.<\/jats:p><jats:p>Die Empfehlung wurde von einer Gruppe unabh\u00e4ngiger internationaler\n                        Expert*innen entwickelt und erg\u00e4nzt die bestehende Empfehlung zur\n                        intrapartalen Antibiotikaprophylaxe bei positivem GBS-Befund. Sie wurde\n                        gem\u00e4\u00df dem WHO-Handbuch f\u00fcr die Leitlinienentwicklung erstellt. Dies\n                        beinhaltet die Bestimmung wichtiger Fragen und Endpunkte, Zusammenfassung\n                        der Evidenz, die Evidenzbewertung anhand des GRADE (Grading of\n                        Recommendations, Assessment, Development and Evaluation) \u2013 Ansatzes sowie\n                        die Formulierung der Empfehlungen durch die Leitlinienentwicklungsgruppe\n                        unter Ber\u00fccksichtigung zus\u00e4tzlicher Faktoren wie Kosten, Werte und\n                        Pr\u00e4ferenzen der Betroffenen, Familien und Auswirkungen auf die\n                        gesundheitliche Chancengleichheit.<\/jats:p><jats:p>Die WHO empfiehlt Schwangere auf die Notwendigkeit einer intrapartalen\n                        Antibiotikaprophylaxe zu testen, um das Risiko einer EOGBS-Erkrankung bei\n                        Neugeborenen zu verringern. Als Screening-Strategie sollte entweder ein\n                        universelles pr\u00e4partales GBS-Screening oder eine risikobasierte Strategie\n                        angeboten werden. Schwangeren mit positivem Testergebnis oder erh\u00f6htem\n                        Risiko sollte eine intrapartale Antibiotikaprophylaxe verabreicht\n                        werden.<\/jats:p>","DOI":"10.1055\/a-2633-6019","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T22:30:27Z","timestamp":1754951427000},"page":"560-563","source":"Crossref","is-referenced-by-count":1,"title":["WHO-Empfehlung zum Screening in der Schwangerschaft f\u00fcr die\n                    intrapartale Antibiotika-Prophylaxe zur Pr\u00e4vention fr\u00fch einsetzender\n                    Gruppe-B-Streptokokken-Erkrankungen bei Neugeborenen"],"prefix":"10.1055","volume":"87","author":[{"given":"Camilla","family":"Neubauer-Bruckner","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Evidenzbasierte Medizin und Evaluation, Universit\u00e4t f\u00fcr\n                    Weiterbildung Krems, Krems, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3592-1507","authenticated-orcid":false,"given":"Isolde","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Evidenzbasierte Medizin und Evaluation, Universit\u00e4t f\u00fcr\n                    Weiterbildung Krems, Krems, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Nu\u00dfbaumer-Streit","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Evidenzbasierte Medizin und Evaluation, Universit\u00e4t f\u00fcr\n                    Weiterbildung Krems, Krems, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s12884-023-05478-9","article-title":"The risk factors for Group B Streptococcus colonization during pregnancy and\n        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