{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:13:11Z","timestamp":1781824391682,"version":"3.54.5"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"name":"Jiangsu applied research of social sciences\n                        programme","award":["Grant No. 20SYB-111"],"award-info":[{"award-number":["Grant No. 20SYB-111"]}]},{"name":"Changzhou Sci&Tech programme","award":["Grant No. 20210162"],"award-info":[{"award-number":["Grant No. 20210162"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies investigating the relationship between the triglyceride-glucose\n                    (TyG) index, a novel marker of insulin resistance (IR), and the risk of chronic\n                    kidney disease (CKD) in the general population have reported conflicting\n                    findings. Therefore, we conducted this meta-analysis to systematically evaluate\n                    the association between the TyG index and CKD risk. Cohort studies estimating\n                    the multivariate-adjusted association between TyG index and CKD were attained by\n                    thoroughly retrieving five databases including PubMed, Cochrane Library, Embase,\n                    Scopus, and Web of Science. A random-effects model was used to analyze the data.\n                    Eleven cohort studies comprising 86 038 participants without CKD at baseline\n                    were included. Results showed that higher TyG index were independently\n                    associated with a higher risk of CKD for highest versus lowest TyG index\n                    category [adjusted RR: 1.52, 95% CI: 1.38\u20131.67, I2=0%, p&lt;0.001].\n                    The results with the TyG index analyzed continuously showed consistent (adjusted\n                    RR per each unit increase of TyG index: 1.29, 95% CI 1.22\u20131.36,\n                    I2=0%, p&lt;0.001). Findings of sensitivity analysis, which ruled out\n                    one dataset at a time, was similar (adjusted RR for categorical variables:\n                    1.48\u20131.60, all p&lt;0.001; adjusted R for continuous variables: 1.28\u20131.38, all\n                    p&lt;0.001). Subgroup analyses suggested study features including ethnicity,\n                    sex, mean age, source of subjects, and the quality scores of studies had no\n                    significant effect on the association (all p&gt;0.05). To summarize, a higher\n                    TyG index may be independently associated with a higher incidence of CKD in\n                    people without CKD at baseline.<\/jats:p>","DOI":"10.1055\/a-2634-0157","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T22:42:37Z","timestamp":1751928157000},"page":"385-395","source":"Crossref","is-referenced-by-count":3,"title":["Relationship Between the Triglyceride-Glucose Index and Chronic\n                    Kidney Disease: A Meta-Analysis of Cohort Studies"],"prefix":"10.1055","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6858-8173","authenticated-orcid":false,"given":"Miaohong","family":"Wang","sequence":"additional","affiliation":[{"name":"Health Management Center, The Third Affiliated Hospital\n                    of Soochow University, Changzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Changzhou Hospital of Traditional\n                    Chinese Medicine, Changzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Third Affiliated\n                    Hospital of Soochow University, Changzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41581-019-0248-y","article-title":"Targeting the progression of chronic kidney disease","volume":"16","author":"M Ruiz-Ortega","year":"2020","journal-title":"Nat Rev 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triglyceride-glucose index patterns with the incidence\n                    of chronic kidney disease among non-diabetic population: evidence from a\n                    functional community cohort","volume":"23","author":"N Chen","year":"2024","journal-title":"Cardiovasc Diabetol"},{"key":"ref22","first-page":"8757996","article-title":"Association between diabetes complications and the triglyceride-glucose index in\n                    hospitalized patients with type 2 diabetes","author":"Y Pan","year":"2021","journal-title":"J Diabetes Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic\n                    reviews","volume":"372","author":"M J Page","year":"2021","journal-title":"BMJ"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a 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Sci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrneph.2016.145","article-title":"The impact of insulin resistance on the kidney and vasculature","volume":"12","author":"F Artunc","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.cmet.2023.01.006","article-title":"The role of hepatokines in NAFLD","volume":"35","author":"N Stefan","year":"2023","journal-title":"Cell Metab"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrneph.2016.145","article-title":"The impact of insulin resistance on the kidney and vasculature","volume":"12","author":"F Artunc","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"sfae065","DOI":"10.1093\/ckj\/sfae065","article-title":"Associations of urinary fetuin-A with histopathology and kidney events in\n                    biopsy-proven kidney 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Arch","volume":"67","author":"M B Reckziegel","year":"2023","journal-title":"Endocrinol Metab"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2634-0157.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T22:43:00Z","timestamp":1751928180000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2634-0157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":35,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2025,7,7]]},"published-print":{"date-parts":[[2025,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2634-0157","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}