{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:23:22Z","timestamp":1765610602099,"version":"3.48.0"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Hintergrund Dakryolithen (DL) findet man bei bis zu 18% der Patienten mit einer chronischen Dakryozystitis (CDZ). Die Studie soll insbesondere die Rolle der neutrophilen Granulozyten bei der Steinentwicklung kl\u00e4ren.<\/jats:p>\n                  <jats:p>Material und Methoden Es wurden 40 histologische Pr\u00e4parate von Patienten mit einer CDZ und bestehender Tr\u00e4nensackektasie untersucht. Hierf\u00fcr wurden Anteile der medialen Saccuswand im Rahmen einer transkutanen Dakryozystorhinostomie gewonnen. Bei 20 Proben bestand eine CDZ ohne DL (Gruppe 1), 20 Patienten zeigten eine fortgeschrittene Dakryolithiasis (Gruppe 2). Die histologischen Kriterien (Entz\u00fcndung, Fibrose, Lymphozyten, Plasmazellen, Makrophagen, neutrophile Granulozyten) wurden mit einem Punktesystem bewertet (0 = nicht vorhanden; 1 = wenig; 2 = moderat; 3 = viel\/stark ausgepr\u00e4gt).<\/jats:p>\n                  <jats:p>Ergebnisse Das Geschlechterverh\u00e4ltnis war ausgeglichen (1\u200a:\u200a1; pro Gruppe 10 weibliche und 10 m\u00e4nnliche Patienten), und der Altersunterschied zwischen Gruppe 1 und 2 war nicht signifikant (Median 53 vs. 56 Jahre; p\u2009=\u20090,482). Die histologischen Parameter wiesen keine signifikanten Unterschiede zwischen den Gruppen 1 und 2 auf (Inflammation: 39\/36, p\u2009=\u20090,292; Fibrose: 21\/20, p\u2009=\u20090,385; Lymphozyten: 37\/32, p\u2009=\u20090,149; Plasmazellen: 25\/24, p\u2009=\u20090,407; Makrophagen: 19\/17, p\u2009=\u20090,152; neutrophile Granulozyten: 10\/13, p\u2009=\u20090,197).<\/jats:p>\n                  <jats:p>Schlussfolgerungen Die histologischen Ver\u00e4nderungen der medialen Tr\u00e4nensackwand bei fortgeschrittener Dakryozystitis sind unabh\u00e4ngig vom Vorhandensein von Dakryolithen. Insbesondere das Vorkommen neutrophiler Granulozyten ist bei Patienten mit l\u00e4nger bestehender Dakryolithiasis nicht erh\u00f6ht.<\/jats:p>","DOI":"10.1055\/a-2635-2419","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T23:04:24Z","timestamp":1756767864000},"page":"1178-1184","source":"Crossref","is-referenced-by-count":1,"title":["Histological Characteristics of Patients with Chronic Dacryocystitis, Depending on the Presence of Advanced Dacryolithiasis"],"prefix":"10.1055","volume":"242","author":[{"given":"Jens","family":"Heichel","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Halle (Saale), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Elisabeth","family":"Burghardt","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Halle (Saale), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Gert","family":"Struck","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Halle (Saale), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"Paulsen","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Funktionelle und Klinische Anatomie, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Deutschland"},{"name":"Institut f\u00fcr Topographische Anatomie und Chirurgie, Sechenov Universit\u00e4t, Moskau, Russland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6363-9202","authenticated-orcid":false,"given":"Mohammad Javed","family":"Ali","sequence":"additional","affiliation":[{"name":"Dacryology, LV Prasad Eye Institute, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Viestenz","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Halle (Saale), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Wickenhauser","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie, Martin-Luther-Universit\u00e4t Halle-Wittenberg, Medizinische Fakult\u00e4t, Halle (Saale), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Die\u00dfel","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie, Martin-Luther-Universit\u00e4t Halle-Wittenberg, Medizinische Fakult\u00e4t, Halle (Saale), Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"ref1","first-page":"435","article-title":"Lacrimal system dacryoliths","volume":"11","author":"A J Berlin","year":"1980","journal-title":"Ophthalmic Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1097\/00002341-198804020-00005","article-title":"The dacryolithiasis syndrome","volume":"4","author":"M J Hawes","year":"1988","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1016\/s0161-6420(01)00596-6","article-title":"Lacrimal sac dacryoliths: predictive factors and clinical characteristics","volume":"108","author":"B Yazici","year":"2001","journal-title":"Ophthalmology"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1007\/s004170050140","article-title":"Functional anatomy of the human efferent tear ducts: a 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