{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:27:53Z","timestamp":1777372073244,"version":"3.51.4"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Evidence for obesity and vitamin D deficiency as components of a data phenotype\n                    for primary hyperparathyroidism (pHPT) is critical to understanding primary\n                    hyperparathyroidism. This study examined the association between vitamin D, body\n                    mass index (BMI), albumin total calcium, parathyroid hormone (PTH) and data from\n                    National Health and Nutrition Examination Survey (NHANES). Associations of\n                    25-hydroxyvitamin D, albumin adjusted calcium, and BMI with elevated PTH were\n                    evaluated, with elevated PTH being defined as&gt;9.02 pmol\/l. Outcomes were PTH\n                    (pmol\/l), 25-hydroxyvitamin D (nmol\/l), albumin adjusted calcium (mmol\/l), and\n                    BMI. A weighted multivariable logistic regression model estimated the\n                    associations. A total of 9740 survey respondents were included in the study,\n                    3.5% had elevated PTH. Mean vitamin D level was 57.7 (SD=22.6) nmol\/l and BMI\n                    was 28.6 (SD=6.5) kg\/m2. A one unit increase in BMI was associated with higher\n                    odds of elevated PTH [adjusted odds ratio (aOR)=1.04; 95% confidence interval\n                    (CI): 1.02, 1.06] whereas a one unit increase in vitamin D (aOR=0.97; 95% CI:\n                    0.96, 0.98) or calcium (aOR=0.51; 95% CI: 0.29, 0.89) had decreased odds of\n                    elevated PTH. Higher BMI and lower levels of 25-hydroxyvitamin D are components\n                    of the primary hyperparathyroidism data phenotype. A refined data phenotype may\n                    improve detection\/management of pHPT.<\/jats:p>","DOI":"10.1055\/a-2638-1810","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T19:05:36Z","timestamp":1751051136000},"page":"409-415","source":"Crossref","is-referenced-by-count":2,"title":["Associations of Obesity, Vitamin D, Adjusted Total Calcium, and\n                    Parathyroid Hormone in US from NHANES"],"prefix":"10.1055","volume":"57","author":[{"given":"Ethan","family":"Frank","sequence":"additional","affiliation":[{"name":"Molecular Biology, Brigham Young University, Provo,\n                    United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Adjei Boakye","sequence":"additional","affiliation":[{"name":"Data Science, Henry Ford Health System, Detroit, United\n                    States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan C.","family":"Stack","sequence":"additional","affiliation":[{"name":"Otolaryngology HNS, Southern Illinois University School\n                    of Medicine, Springfield, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1210\/jc.2012-4022","article-title":"Incidence and prevalence of primary hyperparathyroidism in a racially mixed\n                    population","volume":"98","author":"M W Yeh","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/BF01665300","article-title":"Primary hyperparathyroidism: epidemiology, diagnosis and clinical picture","volume":"15","author":"S Ljunghall","year":"1991","journal-title":"World J 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