{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:04:03Z","timestamp":1762473843322,"version":"build-2065373602"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endoscopic papillectomy is a standard treatment for ampullary lesions, which are typically small and confined to the papillary mound. Laterally spreading lesions (LSLs) of the papilla of Vater are a rare ampullary lesion subtype involving extensive duodenal mucosa. Data on endoscopic papillectomy outcomes for LSLs are limited. This study compared endoscopic papillectomy for ampullary LSLs and non-LSLs in matched cohorts.<\/jats:p>\n                  <jats:p>The ESAP study (Endoscopic papillectomy vs. Surgical Ampullectomy vs. Pancreaticoduodenectomy for ampullary neoplasm) encompassed 1422 endoscopic papillectomies. Propensity score matching used the nearest-neighbor method for age, sex, co-morbidity, and histologic subtype as cofactors. The main outcomes were complete resection (R0), technical success, complications, and recurrences.<\/jats:p>\n                  <jats:p>Propensity score-based matching identified 232 patients with ampullary lesions (116 non-LSL, 116 LSL) with comparable baseline characteristics. After first intervention, the R0 resection rate, the primary outcome measure, was significantly lower in the LSL group (54.3% [95%CI 45.3%\u201363.1%]) vs. 69.0% [95%CI 60.4%\u201376.6%]). Following repeated endoscopic interventions, technical success was similar in both groups (82.8%). After a 22-month median follow-up, the LSL group had significantly more recurrences (41.3% vs. 15.0%) and lower 1- and 3-year disease-free survival rates (61.1% and 44.0% vs. 86.1% and 81.6%, respectively). Complication rates did not differ significantly between the two groups (LSL 32.8% vs. non-LSL 26.7%).<\/jats:p>\n                  <jats:p>LSLs can be safely resected by endoscopic papillectomy, although repeated interventions are necessary to achieve complete resection. The higher risk of recurrence in LSLs necessitates a vigilant surveillance strategy.<\/jats:p>","DOI":"10.1055\/a-2641-0614","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T19:16:45Z","timestamp":1750706205000},"source":"Crossref","is-referenced-by-count":0,"title":["Endoscopic papillectomy for laterally spreading lesions of the papilla: a propensity score-matched analysis"],"prefix":"10.1055","author":[{"given":"Kien","family":"Vu Trung","sequence":"additional","affiliation":[{"name":"Medical Department II, Division of Gastroenterology, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einas","family":"Abou-Ali","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Oncology and Endoscopy, Hospital Cochin, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiste","family":"Gulla","sequence":"additional","affiliation":[{"name":"Surgery, Santaros Klinikos, Lithuanian University of Health Sciences, Kaunas, Lithuania"},{"name":"General Surgery, MedStar Georgetown University Hospital, Washington, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4186-0942","authenticated-orcid":false,"given":"Fabrice","family":"Caillol","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Paoli-Calmettes Institute, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8708-3280","authenticated-orcid":false,"given":"Woo H.","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research institute, Seoul National University Hospital, Seoul, Korea (the Republic of)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5866-8132","authenticated-orcid":false,"given":"Bertrand","family":"Napoleon","sequence":"additional","affiliation":[{"name":"Endoscopy Unit, Hopital Prive Jean Mermoz Ramsay Sante, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asif","family":"Halimi","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences, University Hospital of Ume\u00e5, Umea, Sweden"},{"name":"Division of Surgery, CLINTEC, Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viliam","family":"Masaryk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and General Internal Medicine, SRH Wald-Klinikum Gera, Gera, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco J.","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8254-7453","authenticated-orcid":false,"given":"Enrique","family":"P\u00e9rez-Cuadrado-Robles","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology, H\u00f4pital Europeen Georges-Pompidou - Broussais, Paris, France"},{"name":"Department of Gastroenterology, Cliniques universitaires Saint-Luc, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louisa","family":"Bolm","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Center Schleswig Holstein, Campus Luebeck, Luebeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Seyfried","sequence":"additional","affiliation":[{"name":"Department of Surgery and Interdisciplinary Endoscopy Unit, University Medical Centre Mannheim, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Petrone","sequence":"additional","affiliation":[{"name":"Pancreato-Biliary Endoscopy and Endosonography Division, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengisu","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Vollmer","sequence":"additional","affiliation":[{"name":"Department of Surgery,, University of Pennsylvania Department of Clinical Studies Philadelphia, Philadelphia, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0387-4734","authenticated-orcid":false,"given":"Arthur","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Centre Hospitalier Universitaire d'Angers, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Maggino","sequence":"additional","affiliation":[{"name":"Department of General and Pancreatic Surgery, The Pancreas Institute, University of Verona Hospital Trust, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Schemmer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medical University of Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8832-5031","authenticated-orcid":false,"given":"D\u00f6rte","family":"Wichmann","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Karam","sequence":"additional","affiliation":[{"name":"Digestive Surgery, Centre hospitalo-universitaire de Tours, Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Dugic","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Medizincampus Oberfranken, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Bayreuth, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Regn\u00e9r","sequence":"additional","affiliation":[{"name":"Section for Surgery, Lund University 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Gastroenterol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1055\/s-0034-1364875","article-title":"Endoscopic papillectomy for early ampullary tumors: long-term results from a large multicenter prospective study","volume":"46","author":"B Napoleon","year":"2014","journal-title":"Endoscopy"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1007\/s00464-018-6577-2","article-title":"New experience of endoscopic papillectomy for ampullary neoplasms","volume":"33","author":"S Li","year":"2019","journal-title":"Surg Endosc"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1007\/s00464-016-5141-1","article-title":"Can endoscopic papillectomy be curative for early ampullary adenocarcinoma of the ampulla of Vater?","volume":"31","author":"MV Alvarez-Sanchez","year":"2017","journal-title":"Surg 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