{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:30:20Z","timestamp":1754163020028,"version":"3.41.2"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the efficiency of ultrasound surveillance in detecting\n                        recurrences of papillary thyroid cancer (PTC) in patients with an excellent\n                        response (ER) to therapy.<\/jats:p><jats:p>In a single center, patients diagnosed with PTC between 2000 and 2018 were\n                        evaluated, and data from 477 patients followed up with ultrasonography (USG)\n                        were included in the analysis. The study cohort was divided into excellent\n                        response (ER) and non-excellent response (non-ER) groups. Follow-up\n                        ultrasound scans' positive predictive value (PPV) and negative\n                        predictive value (NPV) were calculated.<\/jats:p><jats:p>The median surveillance time was 76 (36\u2013240) months. Nine recurrences were\n                        observed. The recurrence rate was 0.3% in the ER group. The maximum time\n                        until recurrence after the initial one-year assessment was 1 year in the ER\n                        group, while it extended to 2 years in the non-ER group. Among the 11\n                        patients who underwent fine needle aspiration cytology (FNAC) due to\n                        atypical findings in the ER group, one was found to have metastasis (9%).\n                        The combined PPV of USG in the ER group was only 1.78%. Since no recurrence\n                        was detected in the ER group in later years, the only assessable annual PPV\n                        was in the second year after diagnosis. The ER group exhibited an annual PPV\n                        of 7.69% and an NPV of 100%. In contrast, the non-ER group had annual PPV\n                        and NPV rates of 34.78% and 95.65%, respectively.<\/jats:p><jats:p>Patients with an ER in the first year of treatment can be followed up with\n                        clinical examination and serum unstimulated thyroglobulin alone starting\n                        three years after diagnosis.<\/jats:p>","DOI":"10.1055\/a-2641-2327","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T22:33:05Z","timestamp":1753914785000},"page":"382-390","source":"Crossref","is-referenced-by-count":0,"title":["Efficiency of Ultrasound Screening in Papillary Thyroid Cancer\n                    Patients with Excellent Response to Therapy"],"prefix":"10.1055","volume":"133","author":[{"given":"Bercemhan","family":"Sulu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hacettepe University\n                    School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinem","family":"Ardic","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hacettepe University\n                    School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5054-1396","authenticated-orcid":false,"given":"U\u011fur","family":"\u00dcnl\u00fct\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of\n                    Endocrinology and Metabolism, Hacettepe University School of Medicine, Ankara,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1056\/NEJMc1613118","article-title":"Biologic and clinical perspectives on thyroid cancer","volume":"375","author":"J A Fagin","year":"2016","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1089\/thy.2010.0178","article-title":"Estimating risk of recurrence in differentiated thyroid cancer after total\n                    thyroidectomy and radioactive iodine remnant ablation: Using response to therapy\n                    variables to modify the initial risk estimates predicted by the new American\n                    Thyroid Association staging system","volume":"20","author":"R M Tuttle","year":"2010","journal-title":"Thyroid"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association Management Guidelines for Adult Patients with\n                    Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid\n                    Association guidelines task force on thyroid nodules and differentiated thyroid\n                    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        Thyroid N, Differentiated Thyroid C","year":"2009","journal-title":"Thyroid"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"764","DOI":"10.4158\/EP.14.6.764","article-title":"Risk-adapted management of thyroid cancer","volume":"14","author":"R M Tuttle","year":"2008","journal-title":"Endocr Pract"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.ecl.2008.02.008","article-title":"Follow up approaches in thyroid cancer: A risk adapted paradigm","volume":"37","author":"R M Tuttle","year":"2008","journal-title":"Endocrinol Metab Clin North Am"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1089\/thy.2016.0314","article-title":"Long-term follow-up for differentiated thyroid carcinoma atients: A\n                    reconsideration","volume":"27","author":"R A van der Wardt","year":"2017","journal-title":"Thyroid"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1111\/cen.13053","article-title":"Can the follow-up of patients with papillary thyroid carcinoma of low and\n                    intermediate risk and excellent response to initial therapy be simplified using\n                    second-generation thyroglobulin assays?","volume":"85","author":"P W Rosario","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1089\/thy.2014.0098","article-title":"Management of recurrent\/persistent nodal disease in patients with differentiated\n                    thyroid cancer: A critical review of the risks and benefits of surgical\n                    intervention versus active surveillance","volume":"25","author":"R P 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understand cancer screening statistics? A national survey of\n                    primary care physicians in the United States","volume":"156","author":"O Wegwarth","year":"2012","journal-title":"Ann Intern Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2706","DOI":"10.1210\/jc.2012-1553","article-title":"Suspicious cervical lymph nodes detected after thyroidectomy for papillary\n                    thyroid cancer usually remain stable over years in properly selected\n                    patients","volume":"97","author":"E Robenshtok","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1089\/thy.2011.0011","article-title":"Ultrasonographically detected small thyroid bed nodules identified after total\n                    thyroidectomy for differentiated thyroid cancer seldom show clinically\n                    significant structural progression","volume":"21","author":"G Rondeau","year":"2011","journal-title":"Thyroid"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"i3839","DOI":"10.1136\/bmj.i3839","article-title":"Use of imaging tests after primary treatment of thyroid cancer in the United\n                    States: Population based retrospective cohort study evaluating death and\n                    recurrence","volume":"354","author":"M Banerjee","year":"2016","journal-title":"BMJ"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1089\/thy.2011.2121","article-title":"Metastatic dormancy and progression in thyroid cancer: targeting cells in the\n                    metastatic frontier","volume":"21","author":"M D Ringel","year":"2011","journal-title":"Thyroid"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1111\/cen.14325","article-title":"Frequent neck US in papillary thyroid cancer likely detects non-actionable\n                    findings","volume":"94","author":"K S Sek","year":"2021","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"486","DOI":"10.5603\/EP.a2015.0060","article-title":"Comparison of the usefulness of post-ablative and post-operative thyroglobulin\n                    concentration measuring in prognostic assessment of patients with differentiated\n                    thyroid cancer","volume":"66","author":"K Gadawska-Juszczyk","year":"2015","journal-title":"Endokrynol Pol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1089\/thy.1999.9.421","article-title":"An overview of the management of papillary and follicular thyroid carcinoma","volume":"9","author":"E L Mazzaferri","year":"1999","journal-title":"Thyroid"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1001\/jamaoto.2015.0596","article-title":"Percutaneous ethanol injection vs reoperation for locally recurrent papillary\n                    thyroid cancer: A systematic review and pooled analysis","volume":"141","author":"T E Fontenot","year":"2015","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1245\/s10434-010-1470-9","article-title":"Central compartment reoperation for recurrent\/persistent differentiated thyroid\n                    cancer: Patterns of recurrence, morbidity, and prediction of postoperative\n                    hypocalcemia","volume":"18","author":"J L Roh","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.4158\/EP15851.OR","article-title":"Serial neck ultrasound is more likely to identify false-positive abnormalities\n                    than clinically significant disease in low-risk papillary thyroid cancer\n                    patients","volume":"21","author":"S P Yang","year":"2015","journal-title":"Endocr Pract"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"4142","DOI":"10.1007\/s00268-020-05755-0","article-title":"Ultrasonography for the prediction of high-volume lymph node metastases in\n                    papillary thyroid carcinoma: Should surgeons believe ultrasound results?","volume":"44","author":"C Liu","year":"2020","journal-title":"World J Surg"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3668","DOI":"10.1210\/jc.2002-021925","article-title":"Recombinant human thyrotropin-stimulated serum thyroglobulin combined with neck\n                    ultrasonography has the highest sensitivity in monitoring differentiated thyroid\n                    carcinoma","volume":"88","author":"F Pacini","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"4882","DOI":"10.1210\/jc.2010-0762","article-title":"Identification and optimal postsurgical follow-up of patients with very low-risk\n                    papillary thyroid microcarcinomas","volume":"95","author":"C Durante","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1245\/s10434-012-2802-8","article-title":"Impact of lymph node ratio on survival in papillary thyroid cancer","volume":"20","author":"D F Schneider","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1016\/j.surg.2013.07.008","article-title":"A study of recurrence and death from papillary thyroid cancer with 27 years of\n                    median follow-up","volume":"154","author":"R H Grogan","year":"2013","journal-title":"Surgery"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e2435","DOI":"10.1097\/MD.0000000000002435","article-title":"Short-term follow-up US leads to higher false-positive results without detection\n                    of structural recurrences in PTMC","volume":"95","author":"J H Yoon","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1634\/theoncologist.2009-0324","article-title":"Use of ultrasound in the management of thyroid cancer","volume":"15","author":"J I Lew","year":"2010","journal-title":"Oncologist"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1002\/cncr.28562","article-title":"Annual financial impact of well-differentiated thyroid","volume":"120","author":"C C Lubitz","year":"2014","journal-title":"cancer care in the United States. Cancer"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"3036","DOI":"10.1210\/jc.2016-1440","article-title":"Risk Stratification of Neck lesions detected sonographically during the\n                    follow-up of differentiated thyroid cancer","volume":"101","author":"L Lamartina","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"4087","DOI":"10.1210\/jc.2019-00177","article-title":"Risk Stratification in differentiated thyroid cancer: From detection to final\n                    follow-up","volume":"104","author":"R M Tuttle","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.1210\/jc.2012-1123","article-title":"Long-term surveillance of papillary thyroid cancer patients who do not undergo\n                    postoperative radioiodine remnant ablation: Is there a role for serum\n                    thyroglobulin measurement?","volume":"97","author":"C Durante","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.1210\/jc.2015-4290","article-title":"Dynamic risk stratification in patients with differentiated thyroid cancer\n                    treated without radioactive iodine","volume":"101","author":"D P Momesso","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"R553","DOI":"10.1530\/ERC-19-0213","article-title":"Dynamic risk assessment in patients with differentiated thyroid cancer","volume":"26","author":"F Pitoia","year":"2019","journal-title":"Endocr Relat Cancer"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2641-2327.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T22:33:11Z","timestamp":1753914791000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2641-2327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":37,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2025,7,30]]},"published-print":{"date-parts":[[2025,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2641-2327","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"type":"print","value":"0947-7349"},{"type":"electronic","value":"1439-3646"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}