{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T17:53:17Z","timestamp":1754157197899,"version":"3.41.2"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Bavarian Ministry of Science and the Arts","award":["Bavarian Research Network \u201cNew Strategies Agains"],"award-info":[{"award-number":["Bavarian Research Network \u201cNew Strategies Agains"]}]},{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"crossref","award":["TTU 06.715 (ERANET Bavaria and Helicopredict project)"],"award-info":[{"award-number":["TTU 06.715 (ERANET Bavaria and Helicopredict project)"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early detection of gastric preneoplastic lesions (GPL) is essential to prevent gastric cancer. Endocytoscopy may improve optical diagnosis through in vivo histologic assessment of mucosa. We assessed diagnostic performance of endocytoscopy and interobserver agreement for GPL diagnosis compared with reference histopathology.<\/jats:p><jats:p>Eighty gastric areas (36 antrum, 44 corpus) from 25 prospectively recruited patients were assessed by endocytoscopy and classified as non-preneoplastic, preneoplastic, or dysplastic\/neoplastic by an expert endoscopist. Targeted biopsies from each area served for histopathological assessment. High-quality images\/videos were recorded for independent review by three additional observers (1 expert, 2 non-experts), blinded to endoscopic and histological findings.<\/jats:p><jats:p>Histologically, 25 gastric areas (31.3%) showed GPL, 14 (17.5%) atrophic gastritis, and 11 (13.8%) intestinal metaplasia. Gastric cancer was found in three cases (3.8%). Combined sensitivity, specificity, and accuracy for endocytoscopic diagnosis of GPL or dysplasia were 89.3%, 94.2%, and 92.5% among expert endocytoscopists and 85.7%, 68.3%, and 74.4%, among non-experts, respectively. Interobserver agreement was substantial (\u03ba-value 0.79) between experts and fair (\u03ba-value 0.30) between non-experts.<\/jats:p><jats:p>New-generation endocytoscopy has potential to identify GPL with high diagnostic accuracy, reliability, and reproducibility. Training and clinical experience with endocytoscopy are required to maximize diagnostic performance.<\/jats:p>","DOI":"10.1055\/a-2641-5387","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T19:19:08Z","timestamp":1750706348000},"source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Diagnostic accuracy and interobserver agreement for prediction of gastric preneoplastic lesions with fourth-generation endocytoscopy: Pilot study"],"prefix":"10.1055","volume":"13","clinical-trial-number":[{"clinical-trial-number":"drks00028629","registry":"10.18810\/drks"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7150-5864","authenticated-orcid":false,"given":"Riccardo","family":"Vasapolli","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University Hospital Munich Campus Grosshadern, Munich, Germany"},{"name":"Partner Site Munich, DZIF Deutsches Zentrum f\u00fcr Infektionsforschung, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Macke","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University Hospital Munich Campus Grosshadern, Munich, Germany"},{"name":"Partner Site Munich, DZIF Deutsches Zentrum f\u00fcr Infektionsforschung, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4203-5216","authenticated-orcid":false,"given":"Johannes Raphael","family":"Westphal","sequence":"additional","affiliation":[{"name":"Department of Medicine II, LMU University Hospital, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Neuhaus","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University Hospital Munich Campus Grosshadern, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Schirra","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University Hospital Munich Campus Grosshadern, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens H.L.","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ludwig-Maximilians-University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Mayerle","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University Hospital Munich Campus Grosshadern, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Malfertheiner","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University Hospital Munich Campus Grosshadern, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Medicine II, LMU University Hospital, Munich, Germany"},{"name":"Partner Site Munich, DZIF Deutsches Zentrum f\u00fcr Infektionsforschung, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1136\/gutjnl-2023-331164","article-title":"RE.GA.IN.: the Real-world Gastritis Initiative-updating the updates","volume":"73","author":"M Rugge","year":"2024","journal-title":"Gut"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1055\/a-0859-1883","article-title":"Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study 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