{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:04:15Z","timestamp":1789686255518,"version":"4.0.1"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Short bowel syndrome (SBS) results from a severe reduction in intestinal\n                        absorptive capacity, rendering it insufficient to meet the body's\n                        nutritional requirements. Teduglutide represents a novel therapeutic\n                        approach for patients with SBS. This study aims to share our experiences and\n                        outcomes of Teduglutide treatment in children with SBS, focusing on the\n                        development of their anthropometric parameters.<\/jats:p>\n                  <jats:p>This study included all pediatric SBS patients in the Czech Republic\n                        receiving home parenteral nutrition (PN) who began Teduglutide treatment\n                        from May 2019 to June 2024.<\/jats:p>\n                  <jats:p>We analyzed the changes in volume and caloric content of PN and\n                        anthropometric parameters for each patient.<\/jats:p>\n                  <jats:p>All 10 patients showed a reduction in PN volume and caloric content during\n                        Teduglutide treatment with a mean value 67%+\/\u2212\u200929. There was also a notable\n                        decrease in the caloric content of PN, although this did not always\n                        correlate with the volume reduction, the mean value was 52.3%+\/\u2212\u200940.6.\n                        Despite the reduced reliance on PN, there was a mean improvement in weight\n                        and height among the patients. Gastrointestinal complications were the most\n                        common side effects observed.<\/jats:p>\n                  <jats:p>Our findings confirm the positive impact of Teduglutide on intestinal\n                        absorption in pediatric SBS patients. They also validate its safety and\n                        efficacy in this population. Despite the reduction in PN, improvements in\n                        weight were evident across the entire patient cohort.<\/jats:p>","DOI":"10.1055\/a-2646-0683","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T22:46:47Z","timestamp":1754002007000},"page":"265-271","source":"Crossref","is-referenced-by-count":1,"title":["Reduction of Parenteral Nutrition in Children with Short Bowel\n                    Syndrome Treated with Teduglutide: Experience from the Czech\n                    Republic"],"prefix":"10.1055","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7556-0540","authenticated-orcid":false,"given":"Sarka","family":"Peskova","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Motol University Hospital, Praha, Czech\n                    Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrida","family":"Sulakova","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Ostrava, Ostrava, Czech\n                    Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Bajerova","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Brno Children's\n                    Hospital, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Plzen, Plzen, Czech\n                    Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Melek","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Hradec Kralove, Hradec\n                    Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Karaskova","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Olomouc, Olomouc, Czech\n                    Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Fencl","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Motol University Hospital, Praha, Czech\n                    Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.clnu.2014.08.017","article-title":"ESPEN endorsed recommendations. Definition and classification of intestinal\n                    failure in adults","volume":"34","author":"L Pironi","year":"2015","journal-title":"Clin Nutr"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1136\/gut.2010.218271.","article-title":"Randomised placebo-controlled trial of teduglutide in reducing parenteral\n                    nutrition and\/or intravenous fluid requirements in patients with short bowel\n                    syndrome","volume":"60","author":"P B Jeppesen","year":"2011","journal-title":"Gut"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.cgh.2012.12.029.","article-title":"Safety and efficacy of teduglutide after 52 weeks of treatment in patients with\n                    short bowel intestinal failure","volume":"11","author":"S J O'Keefe","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1053\/j.gastro.2012.09.007.","article-title":"Teduglutide reduces need for parenteral support among patients with short bowel\n                    syndrome with intestinal failure","volume":"143","author":"P B Jeppesen","year":"2012","journal-title":"Gastroenterology"},{"key":"ref5","first-page":"126","article-title":"The 6th nationwide anthropological survey of children and adolescents in the\n                    Czech Republic in 2001","volume":"12","author":"J Kobzov\u00e1","year":"2004","journal-title":"Cent Eur J Public Health"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1097\/MPG.0000000000002899","article-title":"Experience With Teduglutide in Pediatric Short Bowel Syndrome: First Real-life\n                    Data","volume":"71","author":"E Ramos Boluda","year":"2020","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.3390\/nu15102341","article-title":"An Overview of Short-Bowel Syndrome in Pediatric Patients: Focus on Clinical\n                    Management and Prevention of Complications","volume":"15","author":"C Caporilli","year":"2023","journal-title":"Nutrients"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/j.ajcnut.2023.02.019.","article-title":"Long-term treatment with teduglutide: a 48-week open-label single-center\n                    clinical trial in children with short bowel syndrome","volume":"117","author":"C Lambe","year":"2023","journal-title":"Am J Clin Nutr"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.1007\/s00431-024-05577-5.","article-title":"Early use of teduglutide in paediatric patients with intestinal failure is\n                    associated with a greater response rate: a multicenter study","volume":"183","author":"M Germ\u00e1n-D\u00edaz","year":"2024","journal-title":"Eur J Pediatr"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1002\/jpen.1690.","article-title":"Safety and Efficacy of Teduglutide in Pediatric Patients With Intestinal Failure\n                    due to Short Bowel Syndrome: A 24-Week, Phase III Study","volume":"44","author":"S A Kocoshis","year":"2020","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jpeds.2016.10.027.","article-title":"Outcomes from a 12-Week, Open-Label, Multicenter Clinical Trial of Teduglutide\n                    in Pediatric Short Bowel Syndrome","volume":"181","author":"B A Carter","year":"2017","journal-title":"J Pediatr"}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2646-0683.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:30:49Z","timestamp":1789684249000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2646-0683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":11,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2026,9,17]]},"published-print":{"date-parts":[[2026,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2646-0683","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"value":"0300-8630","type":"print"},{"value":"1439-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]}}}