{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T10:03:49Z","timestamp":1768644229178,"version":"3.49.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Small bowel volvulus is a clinical condition that causes intestinal ischemia\u2013reperfusion (I\/R) injury, leading to severe tissue damage and high mortality rates. Polydatin, a natural stilbenoid polyphenol, has demonstrated anti-inflammatory and antioxidant properties. This study aimed to evaluate the protective effects of polydatin on I\/R injury using an experimental small bowel volvulus model.<\/jats:p>\n                  <jats:p>A total of 24 healthy female Wistar albino rats were divided into four groups: Sham (Group 1), Polydatin (Group 2), I\/R (Group 3), and Treatment (Group 4). In Group 1, no I\/R procedure was applied, and intraperitoneal saline was administered. Group 2 received 20\u2009mg\/kg intraperitoneal polydatin without I\/R. In Group 3, a 5-cm segment of the small intestine was twisted 360 degrees clockwise, leading to 2\u2009hours of ischemia and 2\u2009hours of reperfusion. Group 4 received 20\u2009mg\/kg intraperitoneal polydatin before reperfusion. Blood and intestinal tissue samples were collected for biochemical and histopathological analysis.<\/jats:p>\n                  <jats:p>Serum total antioxidant status (TAS) levels were significantly higher in the treatment group compared with the I\/R group (p\u2009=\u20090.004). Serum total oxidant status (TOS) levels were significantly elevated in the I\/R group compared with all other groups (p\u2009&lt;\u20090.001) but were significantly reduced in the treatment group (p\u2009&lt;\u20090.001). Tissue oxidative stress index (OSI) values were significantly lower in the treatment group compared with the I\/R group (p\u2009=\u20090.004). Although serum OSI levels and tissue TAS and TOS values showed a favorable trend, they were not statistically significant. Histopathological evaluations revealed a marked reduction in tissue damage in the treatment group compared with the I\/R group.<\/jats:p>\n                  <jats:p>Polydatin exerts protective effects against I\/R injury in an experimental small bowel volvulus model by reducing oxidative stress and histopathological damage. These findings highlight its therapeutic potential and warrant further clinical research.<\/jats:p>","DOI":"10.1055\/a-2646-1987","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T23:35:43Z","timestamp":1752622543000},"page":"023-028","source":"Crossref","is-referenced-by-count":0,"title":["Polydatin as a Potential Therapeutic in Pediatric Intestinal Volvulus: Evidence from an Experimental I\/R Injury Model"],"prefix":"10.1055","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1429-4690","authenticated-orcid":false,"given":"G\u00f6khan","family":"Arkan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Gazi University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bet\u00fcl","family":"\u00d6\u011f\u00fct","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gazi University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aylar","family":"Poyraz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gazi University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1300-9376","authenticated-orcid":false,"given":"Yusuf Hakan","family":"\u00c7avu\u015fo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Gazi University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3390\/cells12060884","article-title":"Ischemic tolerance\u2014a way to reduce the extent of ischemia-reperfusion damage","volume":"12","author":"R Burda","year":"2023","journal-title":"Cells"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"G63","DOI":"10.1152\/ajpgi.00112.2013","article-title":"Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research","volume":"308","author":"L M Gonzalez","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1111\/ans.17362","article-title":"Congenital midgut malrotation predisposing to small bowel volvulus around left-sided feeding jejunostomy","volume":"92","author":"Z Allan","year":"2022","journal-title":"ANZ J Surg"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1007\/s11605-011-1534-6","article-title":"Primary midgut volvulus in adults: report of two cases and review of the literature","volume":"15","author":"G Papadimitriou","year":"2011","journal-title":"J Gastrointest Surg"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"e0175866","DOI":"10.1371\/journal.pone.0175866","article-title":"Diagnosis, treatment and prognosis of small bowel volvulus in adults: a monocentric summary of a rare small intestinal obstruction","volume":"12","author":"X Li","year":"2017","journal-title":"PLoS One"},{"issue":"02","key":"ref6","first-page":"e54472","article-title":"Primary midgut volvulus: an unusual case of a young adult necessitating extensive bowel resection","volume":"16","author":"I El Nogoomi","year":"2024","journal-title":"Cureus"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"103485","DOI":"10.1016\/j.bioorg.2019.103485","article-title":"Protective effects of polydatin on multiple organ ischemia-reperfusion injury","volume":"94","author":"Z Sun","year":"2020","journal-title":"Bioorg Chem"},{"issue":"19","key":"ref8","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.3390\/molecules27196474","article-title":"Polydatin: pharmacological mechanisms, therapeutic targets, biological activities, and health benefits","volume":"27","author":"A Karami","year":"2022","journal-title":"Molecules"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1055\/s-0034-1387945","article-title":"Increased inflammatory reaction to intestinal ischemia-reperfusion in neonatal versus adult mice","volume":"25","author":"Y Yu","year":"2015","journal-title":"Eur J Pediatr Surg"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/archsurg.1970.01340280030009","article-title":"Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal","volume":"101","author":"C J Chiu","year":"1970","journal-title":"Arch Surg"},{"issue":"02","key":"ref11","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1055\/s-0037-1618593","article-title":"Effect of N-acetylserotonin on TLR-4 and MyD88 expression during intestinal ischemia-reperfusion in a rat model","volume":"29","author":"I Sukhotnik","year":"2019","journal-title":"Eur J Pediatr Surg"},{"issue":"07","key":"ref12","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1080\/08941939.2022.2056273","article-title":"Protective effects of hydrogen-rich saline on experimental intestinal volvulus in rats","volume":"35","author":"H Oral","year":"2022","journal-title":"J Invest Surg"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1016\/j.jpedsurg.2019.02.011","article-title":"Experimental study on prophylactic effects of vardenafil in ischemia-reperfusion model with intestinal volvulus injury in rats","volume":"54","author":"G Do\u011fan","year":"2019","journal-title":"J Pediatr Surg"},{"issue":"07","key":"ref14","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.jpedsurg.2022.02.029","article-title":"Human breast milk-derived exosomes protect against intestinal ischemia and reperfusion injury in neonatal rats","volume":"57","author":"L Wang","year":"2022","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s10753-011-9310-z","article-title":"Anti-inflammatory effect of resveratrol and polydatin by in vitro IL-17 modulation","volume":"35","author":"G Lanzilli","year":"2012","journal-title":"Inflammation"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.phymed.2008.10.001","article-title":"Lipid-lowering effects of polydatin from Polygonum cuspidatum in hyperlipidemic hamsters","volume":"16","author":"J Du","year":"2009","journal-title":"Phytomedicine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"106840","DOI":"10.1016\/j.bioorg.2023.106840","article-title":"Mechanisms of polydatin against spinal cord ischemia-reperfusion injury based on network pharmacology, molecular docking and molecular dynamics simulation","volume":"140","author":"Z Sun","year":"2023","journal-title":"Bioorg Chem"},{"issue":"33","key":"ref18","first-page":"6111","article-title":"Effects of polydatin on the biological features of cultured fibroblasts","volume":"16","author":"H N Bian","year":"2012","journal-title":"Chin J Tissue Engineer Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fct.2012.10.037","article-title":"Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice","volume":"52","author":"L Chen","year":"2013","journal-title":"Food Chem Toxicol"},{"issue":"01","key":"ref20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.brainres.2006.06.065","article-title":"Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury","volume":"1110","author":"Y Cheng","year":"2006","journal-title":"Brain Res"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3109\/13880209.2013.792849","article-title":"Polydatin: a review of pharmacology and pharmacokinetics","volume":"51","author":"Q H Du","year":"2013","journal-title":"Pharm Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.fct.2016.07.032","article-title":"Polydatin ameliorates renal ischemia\/reperfusion injury by decreasing apoptosis and oxidative stress through activating sonic hedgehog signaling pathway","volume":"96","author":"Q H Meng","year":"2016","journal-title":"Food Chem Toxicol"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1071\/RD17046","article-title":"Protective effects of polydatin on experimental testicular torsion and detorsion injury in rats","volume":"29","author":"H Qiao","year":"2017","journal-title":"Reprod Fertil Dev"},{"issue":"07","key":"ref24","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.21037\/qims-20-1160","article-title":"Photoacoustic imaging in evaluating early intestinal ischemia injury and reperfusion injury in rat models","volume":"11","author":"R Wang","year":"2021","journal-title":"Quant Imaging Med Surg"},{"issue":"02","key":"ref25","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.3892\/mmr.2016.5432","article-title":"Polydatin possesses notable anti-osteoporotic activity via regulation of OPG, RANKL and \u03b2-catenin","volume":"14","author":"Q L Zhou","year":"2016","journal-title":"Mol Med Rep"},{"issue":"01","key":"ref26","first-page":"133","article-title":"Effect of polydatin on expression of p53 and Notch1 in brain tissue of ischemic cerebrovascular disease","volume":"32","author":"F Y Chen","year":"2018","journal-title":"J Biol Regul Homeost Agents"},{"key":"ref27","first-page":"16","article-title":"The relationship between preoperative plasma total antioxidant capacity and ischemia-reperfusion injury in patients undergoing coronary artery bypass surgery","volume":"22","author":"A Taskiran","year":"2005","journal-title":"Balkan Med J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.epsc.2017.05.017","article-title":"Urokinase thrombolysis as a rescue treatment for midgut volvulus ischemia","volume":"23","author":"F Leon","year":"2017","journal-title":"J Pediatr Surg Case Rep"}],"container-title":["European Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2646-1987.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T23:41:51Z","timestamp":1768606911000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2646-1987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":28,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2026,1,16]]},"published-print":{"date-parts":[[2026,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2646-1987","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0939-7248","1439-359X"],"issn-type":[{"value":"0939-7248","type":"print"},{"value":"1439-359X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]}}}