{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:18:54Z","timestamp":1783120734801,"version":"3.54.6"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Advances in endoscopic endonasal approaches in ventral skull base surgery have led to increasingly complex resections and reconstructions. This study investigates differences in postoperative outcomes, including postoperative cerebrospinal fluid (CSF) leak and infection, following anterior skull base surgery and reconstruction, as a function of the type of nasal packing (absorbable vs. nonabsorbable) used to bolster the skull base reconstruction.<\/jats:p>\n                  <jats:p>A retrospective chart review was performed at a single tertiary care institution. Patients who underwent ventral skull base surgery with placement of nasal packing between January 1, 2020, and December 1, 2023, were included. We included only patients of a single rhinologist (S.L.) involved. Outcome measures included postoperative CSF leaks and postoperative infection.<\/jats:p>\n                  <jats:p>Of the 179 patients meeting inclusion criteria, 105 patients (58.7%) received absorbable nasal packing (Nasopore), and 72 patients (40.2%) received nonabsorbable nasal packing (Merocel). Fifteen postoperative leaks occurred overall, with six CSF leaks reported in patients with absorbable nasal packing (5.7%) and nine CSF leaks reported in patients with Merocel packing (12.5%). Fifteen cases of postoperative infection were recorded, with nine cases in patients with absorbable nasal packing (8.6%) and six cases in patients with nonabsorbable nasal packing (8.3%). Overall, no statistically significant difference was found for the rate of postoperative CSF leak (p\u2009=\u20090.168) or infection (p\u2009=\u20090.309) between these two cohorts of patients.<\/jats:p>\n                  <jats:p>While no significant differences were found in the rate of postoperative CSF leak or infection, additional patient factors should be taken into consideration when choosing between absorbable and nonabsorbable nasal packing for ventral skull base reconstruction.<\/jats:p>\n                  <jats:p>4.<\/jats:p>","DOI":"10.1055\/a-2646-2482","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T23:31:57Z","timestamp":1752535917000},"page":"e110-e114","source":"Crossref","is-referenced-by-count":0,"title":["Comparing the Effects of Absorbable versus Nonabsorbable Nasal Packing on Postoperative Outcomes Following Endoscopic Ventral Skull Base Surgery"],"prefix":"10.1055","volume":"87","author":[{"given":"Maya","family":"Hatley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, NYU Langone Health, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4758-6671","authenticated-orcid":false,"given":"Mackenzie","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, NYU Langone Health, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Lebowitz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, NYU Langone Health, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7079-3304","authenticated-orcid":false,"given":"Joseph","family":"Connors","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, NYU Langone Health, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, NYU Langone Health, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Santacatterina","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, NYU Langone Health, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Pacione","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NYU Langone Health, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Lieberman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, NYU Langone Health, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1177\/0194599814520685","article-title":"Endoscopic reconstruction of surgically created skull base defects: a systematic review","volume":"150","author":"E Soudry","year":"2014","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1001\/archoto.2011.12","article-title":"Choice of graft material and postoperative healing in endoscopic repair of cerebrospinal fluid leak","volume":"137","author":"K K Prickett","year":"2011","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1055\/s-0030-1253573","article-title":"How to choose? Endoscopic skull base reconstructive options and limitations","volume":"20","author":"M R Patel","year":"2010","journal-title":"Skull Base"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.3171\/2012.5.FOCUS1255","article-title":"Surgical nuances for nasoseptal flap reconstruction of cranial base defects with high-flow cerebrospinal fluid leaks after endoscopic skull base surgery","volume":"32","author":"J K Liu","year":"2012","journal-title":"Neurosurg Focus"},{"issue":"08","key":"ref5","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1002\/lary.31390","article-title":"Tissue sealant impact on skull base reconstruction outcomes: A systematic review and meta-analysis","volume":"134","author":"J C Pang","year":"2024","journal-title":"Laryngoscope"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1007\/s10143-021-01641-y","article-title":"The incidence of postoperative cerebrospinal fluid leakage after elective cranial surgery: a systematic review","volume":"45","author":"B Coucke","year":"2022","journal-title":"Neurosurg Rev"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3171\/2016.12.JNS1694","article-title":"Risk factors associated with postoperative cerebrospinal fluid leak after endoscopic endonasal skull base surgery","volume":"128","author":"S Fraser","year":"2018","journal-title":"J Neurosurg"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1080\/00016489.2021.1900600","article-title":"Risk factor for cerebrospinal fluid leak after endoscopic endonasal skull base surgery: A single-center experience","volume":"141","author":"H Ozawa","year":"2021","journal-title":"Acta Otolaryngol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijporl.2016.12.019","article-title":"Risk factors for cerebrospinal fluid leak in pediatric patients undergoing endoscopic endonasal skull base surgery","volume":"93","author":"A L Stapleton","year":"2017","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-031-27937-9_28","volume-title":"Postoperative management following skull base reconstruction","author":"P Papagiannopoulos","year":"2023"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e406","DOI":"10.1016\/j.wneu.2021.07.031","article-title":"Role of anterior nasal packing in endoscopic skull base surgery: Italian survey","volume":"154","author":"M Ceraudo","year":"2021","journal-title":"World Neurosurg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jocn.2018.03.001","article-title":"Corrigendum to \u201cReconstructive outcome of intraoperative cerebrospinal fluid leak after endoscopic endonasal surgery for tumors involving skull base\u201d [J. Clin. Neurosci. 45 (2017) 227\u2013231]","volume":"58","author":"C Jeon","year":"2018","journal-title":"J Clin Neurosci"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/alr.23041","article-title":"Postoperative protocols following endoscopic skull base surgery: An evidence-based review with recommendations","volume":"13","author":"A Abiri","year":"2023","journal-title":"Int Forum Allergy Rhinol"},{"issue":"05","key":"ref14","first-page":"476","article-title":"Sinonasal packing is not a requisite for successful cerebrospinal fluid leak repair","volume":"83","author":"K Asmaro","year":"2021","journal-title":"J Neurol Surg B Skull Base"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1186\/s12883-021-02440-0","article-title":"Risk factors for postoperative cerebrospinal fluid leakage after transsphenoidal surgery for pituitary adenoma: a meta-analysis and systematic review","volume":"21","author":"Z Zhou","year":"2021","journal-title":"BMC Neurol"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1002\/alr.23406","article-title":"American Rhinologic Society expert practice statement part 2: Postoperative precautions and management principles following endoscopic skull base surgery","volume":"14","author":"J E Douglas","year":"2024","journal-title":"Int Forum Allergy Rhinol"},{"issue":"S 04","key":"ref17","doi-asserted-by":"crossref","first-page":"S300","DOI":"10.1055\/s-0038-1669463","article-title":"The endoscopic endonasal management of anterior skull base meningiomas","volume":"79","author":"M Zoli","year":"2018","journal-title":"J Neurol Surg B Skull Base"}],"container-title":["Journal of Neurological Surgery Part B: Skull Base"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2646-2482.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:34:00Z","timestamp":1783118040000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2646-2482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":17,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2026,7,3]]},"published-print":{"date-parts":[[2026,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2646-2482","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6331","2193-634X"],"issn-type":[{"value":"2193-6331","type":"print"},{"value":"2193-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,14]]}}}