{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:07:04Z","timestamp":1790125624176,"version":"4.0.1"},"reference-count":65,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zentralbl Chir"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die Behandlung des Rektumkarzinoms orientiert sich am Tumorstadium, der Lage sowie morphologischen und biologischen Risikofaktoren. Sie erfolgt multimodal mittels Chirurgie, Strahlentherapie und Chemotherapie. In einer Vielzahl von F\u00e4llen existieren mehrere Behandlungskorridore, die teils \u00e4hnliche, teils unterschiedliche funktionelle Einschr\u00e4nkungen bedingen k\u00f6nnen. Vergleiche der funktionellen Ergebnisse der verschiedenen Behandlungsmodalit\u00e4ten liegen derzeit nur eingeschr\u00e4nkt vor.<\/jats:p>\n                  <jats:p>In diesem narrativen Review werden die funktionellen Folgen verschiedener Behandlungsstrategien des Rektumkarzinoms des mittleren und unteren Drittels basierend auf einer Literaturrecherche dargestellt.<\/jats:p>\n                  <jats:p>Diese Arbeit analysiert die Evidenzlage zu den funktionellen Outcomes der einzelnen Therapieformen, insbesondere hinsichtlich Stuhlkontinenz, Harn- und Sexualfunktion. Das funktionelle Ergebnis nach organerhaltenden Strategien scheint hinsichtlich der Stuhlfrequenz geringf\u00fcgig besser im Vergleich zur alleinigen chirurgischen Therapie zu sein, jedoch sind dem eine chemotherapieinduzierte Polyneuropathie und radiogene Toxizit\u00e4ten wie Zystitis, Radionekrose oder Fistelbildung entgegenzusetzen. Zudem kumulieren bei inkompletter Remission die funktionellen Nebenwirkungen von perioperativer und operativer Therapie. Wenigen Tagen Behandlungsdauer bei chirurgischer Therapie steht die deutlich l\u00e4ngere Behandlungsdauer einer totalen neoadjuvanten Therapie gegen\u00fcber. Eine abschlie\u00dfende Bewertung auf dem Boden der aktuellen Studienlage ist derzeit nur eingeschr\u00e4nkt m\u00f6glich.<\/jats:p>\n                  <jats:p>Diese Arbeit hebt die Bedeutung einer differenzierten Aufkl\u00e4rung der Patienten \u00fcber funktionelle Konsequenzen, Therapiedauer und m\u00f6gliche Komplikationen hervor und bietet eine Entscheidungshilfe f\u00fcr eine individuelle Therapieplanung unter Ber\u00fccksichtigung der Lebensqualit\u00e4t.<\/jats:p>","DOI":"10.1055\/a-2646-2695","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T22:44:22Z","timestamp":1754693062000},"page":"353-361","source":"Crossref","is-referenced-by-count":3,"title":["Funktionelle Folgen von Radiotherapie, Chemotherapie und Operation bei der Behandlung des 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